Global ETD Search
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Showing 1 to 16 of 16 for “"Fluid Percussion Injury"”.
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Iterative learning control for improved tracking of fluid percussion injury device
Traumatic brain injury (TBI) afflicts over 10 million people around the world. Injury to the brain can occur from a variety of physical insults and the degree of disability can greatly vary from person to person. It is likely that the wide range of TBI outcomes may be due to the magnitude, …
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The Effects of Aniracetam Treatment on Cognitive Performance and AMPA Receptor GluR2 Subunit Expression After Moderate Fluid Percussion Injury in Rats
… the acute pathology produced by traumatic brain injury, there are chronic alterations that occur after the trauma, including a depressed state of neuronal activity (Feeney, 1991). This study included a preclinical testing of a novel treatment strategy focusing on increasing neuronal activity …
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The role of nitric oxide and prostaglandin E2 in prolonged hemorrhagic shock
… combine model of prolonged hemorrhagic shock and fluid percussion injury. Our studies showed that the selective inhibitor, AG, maybe beneficial as a potentially useful therapeutic agent in our model of prolonged hemorrhagic shock and the combine model of prolonged hemorrhagic shock and fluid …
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Modeling subconcussive and cumulative subconcussive impacts using a lateral fluid percusion injury device
… scientific community. This study used a lateral fluid percussion injury (lFPI) to model a subconcussive insult; specifically, to test the hypothesis that an initial subconcussive insult will not lead to any significant detectable levels of behavioral or cellular damage, yet cumulative intra-day …
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Onset of Insulin Resistance in Hippocampal Synapses After Traumatic Brain Injury: Relevance to Alzheimer’s disease and Therapeutic Implications
Traumatic brain injury (TBI) is a risk factor for the later development of Alzheimer’s disease (AD), although the mechanisms contributing to this increased risk are unknown. Insulin resistance is an additional risk factor for AD whereby decreased insulin signaling increases synaptic sensitivity to …
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Traumatic Brain Injury Accelerates Alzheimer’s Disease Pathology in the TgF344-AD Rat Model
… evidence shows that Traumatic Brain Injury (TBI) is a risk factor for Alzheimer’s disease (AD). TBI and AD have common overlapping pathologies. However, the underlying mechanisms are not clearly understood, and there are no effective treatments for TBI and AD. Aim of the study is to …
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FEAR EXTINCTION AND INFRALIMBIC CORTEX IMPAIRMENT AFTER MILD TRAUMATIC BRAIN INJURY
Traumatic brain injury (TBI) is a leading cause of morbidity and disability, with mild TBI (concussions) representing over 80% of cases. Although often considered benign, mild TBI is associated with persistent neuropsychiatric conditions, including posttraumatic stress disorder, anxiety, and …
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Translational Studies of Acute and Chronic Traumatic Brain Injury: Molecular Profiling of Tissue and Biofluids
Traumatic brain injury (TBI) is a leading contributor to the global burden of disease. Despite the growing awareness of TBI and years of research into biomechanics and pathophysiologic mechanisms, there is still a lack of effective therapies to treat patients. To better understand the genomic …
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Membrane-bound Matrix Metalloproteinases Influence Reactive Synaptogenesis Following Traumatic Brain Injury
Traumatic brain injury (TBI) produces axonal damage and deafferentation, triggering injury-induced synaptogenesis, a process influenced by matrix metalloproteinases (MMP) and their substrates. Here we report results of studies examining the expression and potential role of two membrane-bound MMPs, …
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Adult hippocampal neurogenesis: traumatic brain injury-induced dysregulation and therapeutic potentials of a novel non-invasive nano-pulsed laser treatment
… diseases and after traumatic brain injury (TBI). In this work, I aimed to study TBI-induced dysregulation of neurogenesis and to assess the therapeutic potential of a highly innovative non-invasive device, combining the benefits of both near infrared laser light (808nm) and …
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Adult hippocampal neurogenesis: traumatic brain injury-induced dysregulation and therapeutic potentials of a novel non-invasive nano-pulsed laser treatment
… diseases and after traumatic brain injury (TBI). In this work, I aimed to study TBI-induced dysregulation of neurogenesis and to assess the therapeutic potential of a highly innovative non-invasive device, combining the benefits of both near infrared laser light (808nm) and …
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Investigating the cerebral/pulmonary axis following traumatic brain injury in a preclinical model
Traumatic Brain Injury (TBI) accounts for 1,000,000 hospital admissions in the European Union every year and is the leading cause of death in individuals under 45 years of age in both Europe and the United States. This thesis examines the consequences to both the brain and lung following TBI using …
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Monitoring of cerebellar injury using micro ECoG signals in ketamine/xylazine treated rats
… was used as a method to study traumatic brain injury (TBI). This research demonstrated the use of cerebellar evoked potentials (EPs), which was characterized in the first phase of the study, for monitoring the injury progression in a rat model of fluid percussion injury (FPI). A mechanical tap …
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Investigation of chemokine expression and modulation following traumatic brain injury
… of the pathophysiology of severe traumatic brain injury (TBI) and in particular the contribution of secondary injury to poor outcome, has served to improve clinical management and reduce the mortality in these patients. However despite many promising preclinical studies there has been a failure to …
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Zinc-mediated cell death in the hippocampus following experimental traumatic brain injury
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality of Americans both in the 15-25 age range and in the elderly population. Hippocampal neuronal damage is a key feature of experimental fluid percussion traumatic brain injury in rodents. However, the mechanisms contributing to …
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Spatial light interference microscopy (slim) measurements of hypothermia in an experimental cellular model of traumatic brain injury
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms