Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"Fluconazole"”.
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Investigation of Clinically Relevant Fluconazole Resistance Mechanisms in the Fungal Pathogen Candida parapsilosis
… Southern Africa. For many of these countries, fluconazole and other triazoles are the first line antifungal agents used for effective treatment of invasive Candida infection. Until recently, rates of fluconazole resistance among C. parapsilosis isolates were relatively low, therefore the …
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RAPD-PCR DNA fingerprinting on sequential isolates of Histoplasma capsulatum from AIDS patients failing fluconazole therapy
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Expression Pattern of Drug-Resistance Genes in Matched Clinical Isolates of Candida albicans at Variable Fluconazole Exposure Times
… A common drug used to treat these infections is fluconazole (FLC), a fungistatic azole targeting lanosterol 14α-demethylase (Erg11) in the ergosterol biosynthesis pathway. In some clinical isolates, resistance to FLC is due to overexpression of a) the encoding genes CDR1 and CDR2 for the ABC …
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Signal Transduction and Transcriptional Regulation Pathways Essential for Azole Resistance in Candida albicans
… virus (HIV). The azole antifungals (such as fluconazole) are the most widely used and important ergosterol biosynthesis inhibitors (EBIs) for the treatment of Candida infections, including OPC. However, the azoles are fungistatic against C. albicans and therefore have limited efficacy against …
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Delineating the Upc2A Regulon in Candida glabrata
… limited the utility of the triazole antifungal, fluconazole, in the treatment of invasive fungal infection. The transcription factor Upc2 regulates the expression of sterol biosynthesis genes in yeast. Disrupting UPC2A in C. glabrata greatly increases its susceptibility to fluconazole (FLU) in …
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Phenotypic and molecular antifungal susceptibility testing of yeast isolates from Pretoria
… by the Etest for three azole antifungals (fluconazole, posaconazole and voriconazole), amphotericin B and caspofungin. Clinical breakpoint susceptibility was determined according to the CLSI clinical breakpoint reference methods. Polymerase chain reaction was performed on C. albicans …
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Supramolecular derivatisation of bioactive molecules via co-crystallization and cyclodextrin inclusion complexation
… is a powerful anti-inflammatory drug and fluconazole has a strong antibacterial and antifungal activity. The common feature is their very low solubility in water. Cyclodextrin inclusion complexation and co-crystallization were carried out with the aim of ultimately improving the …
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Functional Analysis of Synthetic Gene Circuits Controlling A Protein Pump In Yeast
… NRpump, NFpump and PFpump strains in a fluconazole-containing environment. While PFpump cells maintained fluconazole sensitivity, NRpump and NFpump cells started to develop fluconazole resistance after 48 hours. Expression of Pdr5 was the cause of resistance. The elevated Pdr5 expression …
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Novel Determinants That Influence Azole Susceptibility in Candida glabrata and Candida albicans
… of <em>UPC2A </em>would enhance the activity of fluconazole in both azole-susceptible-dose dependent (SDD) and -resistant <em>C. glabrata </em>clinical isolates. To test this hypothesis, we constructed mutants disrupted for <em>UPC2A </em>and <em>UPC2B </em>alone and in combination in a matched …
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ERG11-Mediated Azole Resistance in Candida albicans
… <em>ERG11</em> has also been shown to decrease fluconazole susceptibility. <em>ERG11</em> gene amplification by chromosome 5 duplication or the presence of a chr5L isochromosome is known to contribute to azole resistance. Additionally, the zinc-cluster transcription factor <em>Upc2</em> has been …
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Comparative structural analysis of cytochrome P450 family CYP51 in the genus Cryptococcus
… is a well-known target of the azole drug fluconazole for treating cryptococcosis, a life-threatening fungal infection in immune-compromised patients in poor countries. Studies indicate that mutations in CYP51 confer fluconazole resistance on cryptococcal species. Despite the importance of …
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Analysis of clnical features of cryptococcosis and antifungal susceptibility of clinical isolates in Korea
… 33%(6/18) and 75%(3/4). MIC90 and MIC range for fluconazole, amphotericin B, and voriconazole by broth microdilution test were 8 μg/ml(1-16 μg/ml), 0.5 μg/ml(0.06-0.5 μg/ml) and 0.125 μg/ml(0.03-0.25 μg/ml). MIC range and MIC90 for fluconazole, amphotericin B, flucytosine by Vitek 2 system were 2 …
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Transcriptional Regulation of Azole Antifungal Resistance in Candida albicans
… superfamily, is another cause of resistance to fluconazole in clinical C. albicans strains. The regulator of MDR1 gene expression has not been identified or characterized. Using genome-wide gene expression profiling, we have identified a gene encoding a zinc cluster transcription factor, …
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Transcriptional Regulation of Azole Antifungal Resistance and Tolerance in Candida Glabrata
… glabrata</em> <em>PDR1</em> conferred equivalent fluconazole hypersensitivity (MIC = 2 μg/ml) to both F15 and 66032 and eliminated both constitutive and fluconazole-induced <em>CDR1</em>-<em>PDH1</em> expression. Reintroduction of wild-type or F15 <em>PDR1</em> alleles fully reversed these …
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The Development and Evaluation of a Range of Phototherapeutic Dyes Towards Infection Control
… inhibitory concentration when compared with fluconazole when illuminated with blue light. The hydroxy anthrone also showed the same minimum inhibitory concentration has fluconazole when illuminated with blue light.
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Substrate Utilization of the Emerging Fungal Pathogen, Candida auris, and the Antifungal Activity of Select Essential Oils
… were also the oils used in combination with fluconazole, amphotericin B, flucytosine and micafungin. While cinnamon bark oil displayed little interaction with the drugs, lemongrass oil displayed positive or neutral interactions with all four drugs, while clove bud oil had mixed results. The …
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Discovery and development of novel antifungal agents for the treatment of Candida auris infections
… significant resistance, especially to azoles (fluconazole) and polyenes (amphotericin B, AmB). To address this, we screened approximately 2,600 FDA-approved drugs and clinical compounds to identify agents capable of inhibiting C. auris growth and enhancing or restoring the antifungal activity …
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Developing novel drug combinations for treatment of invasive fungal infections
… resistance capability especially against azole (fluconazole) and polyene (amphotericin B) antifungals. Here, we utilized the combinatorial strategy to screen ~3400 FDA-approved drugs and clinical compounds to identify hits that can enhance/restore the antifungal activity of azoles and …
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DEVELOPMENT OF PROTEIN-BASED ANTIFUNGALS
… of molecular drugs like Amphotericin B, Fluconazole and Caspofungin but they have their own shortcomings. The field of antifungal biologic therapy is relatively unexplored given the orphan status of invasive mycosis. Antifungal biologics offer the possibility of treating invasive mycosis …
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Genetically Engineered Wound Dressing for Sensing and Treating Candida albicans Infections in Diabetic Foot Ulcers
… are typically treated with azoles like fluconazole. There is an unmet need to develop new strategies to detect and treat Candida infections. In this work, we developed hydrogel-based Engineered Living Materials (ELMs) as an antifungal wound dressing. Additionally, to increase the …
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