Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Flt3L"”.
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Enhancing Chimeric Antigen Receptor T cell therapy in Mouse EGFRvIII Heterogeneous Glioblastoma
… Here, we orthotopically delivered IL7 and/or Flt3L expressing CAR T cells in 50% EGFRvIII-positive and -negative tumors pre-conditioned with non-lymphodepleting irradiation. IL7 and IL7 Flt3L CAR T cells increased intratumoral CD8 CAR T cell populations seven days after treatment. IL7 …
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DISSECTING THE ROLES OF DISTINCT DENDRITIC CELL SUBSETS IN THE IMMUNE RESPONSE TO THE INTRACELLULAR BACTERIAL PATHOGEN, LISTERIA MONOCYTOGENES
… the cytokine, Fms-like tyrosine kinase 3-ligand (Flt3L). We therefore set out to determine how distinct DC subsets respond and contribute to immune response against the intracellular bacteria pathogen, Listeria monocytogenes (Lm). We observed, in contrast to previous studies, that in Flt3L DC …
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Engineered Type 1 Conventional Dendritic Cell–Based Therapies for In Situ Cancer Immunization
… factor, FMS-like tyrosine kinase 3 ligand (Flt3L), were synthesized and intratumorally injected to induce Flt3L expression, resulting in cDC1 expansion and enabling in vivo cDC1 generation. With increased cDC1 population in tumors, Flt3L-LNPs enhanced T cell infiltration and modulated the …
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Deciphering pre-leukaemic dysregulation caused by mutant C/EBPα at the level of the single cell
… cells had immature morphological appearance in Flt3L differentiation media, proliferated indefinitely, and were characterised by a plasmacytoid dendritic cell (pDC)-like immunophenotype. These cells were capable of long-term engraftment in a mouse model but did not recapitulate leukaemia for …
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Regulation of type I interferons in murine dendritic cells
… Trex1 deficiency preferentially represses Flt3L-induced DC development both in vitro and in vivo but not GM-CSF-dependent DC development, suggesting that Trex1 plays an indispensable role in Flt3L-induced DC development and GM-CSF may compensate the effect of Trex1 deficiency. This defect …
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Tailored influenza virus vaccines for both the young and old: Vaccine Efficacy of Whole Inactivated Vaccines bearing Immunomodulatory Adjuvants or Multimeric peptides
… cytokines includes IL-2, IL-4, IL-12, IL-23, and Flt3L as well as the multimeric M2e peptide, all fused to the membrane anchoring regions of influenza virus hemagglutinin protein and constitutively expressed in virus permissive MDCK cell line. Subsequent infection with influenza virus results in …
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Molecular signatures underlying the tumourigenic transformation in a CEBPA mutated model of leukaemia
… cells with the supplementation of Flt3 ligand (Flt3L). However, Hoxb8-FL cells transduced with the CEBPA N321D construct failed to terminally differentiate upon addition of Flt3L, thereby retaining self-renewal properties. Flow cytometry and transcriptomic profiling showed that the mutant cells …
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Development Of Thymic Natural Killer Cells From Double Negative 1 Thymocyte Precursors
… of IL15, IL7, FMS-like tyrosine kinase 3 ligand: Flt3L) and stem cell factor: SCF). Flow cytometry results showed NK1.1<super>&plus</super> cells emerged after at least 7 days in culture. By using limiting dilution analysis, we demonstrated a cell frequency of 0.24%: 1 out of 414 sorted thymocytes …
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Dissecting the early steps of MLL induced leukaemogenic transformation using a new mouse model of AML
… in vitro in the presence of Flt3 ligand (Flt3L) and an estrogen (β-estradiol)-regulated form of Hoxb8, and show lympho-primed multipotent progenitor (LMPP)-like differentiation capacity both in vitro and in vivo. Transduction experiments generated MLL-ENL expressing Hoxb8-FL cells which, …