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Showing 1 to 15 of 15 for “"Flt-1"”.
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Role of the Intron 13 Polypyrimidine Tract in Soluble Flt-1 Expression
… via interactions with its receptors, KDR and Flt-1. A secreted form of Flt-1 (sFlt-1), derived from alternatively-spliced RNA, can inhibit actions of VEGF in vivo. It has been suggested that alterations in sFlt-1 expression could significantly change the angiogenic VEGF activity. This project …
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Modeling of interactions between vascular endothelial growth factor family members and their receptors KDR and Flt-1
… tumor growth. Responses to VEGF are mediated by Flt-1 and KDR, two cell-surface receptors selectively expressed by vascular endothelial cells. A secreted form of Flt-1 (sFlt1) retains high affinity for VEGF and can compete for VEGF binding, thereby inhibiting angiogenic responses. In this study, …
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Role of RNA Processing Factors in the Expression of Flt-1 and its Secreted Variant, sFlt-1
… the formation of new blood vessels. sFlt-1, a secreted form of the signal-transducing VEGF receptor Flt-1, can inhibit cellular responses to VEGF both in vitro and in vivo. sFlt-1 is generated by alternative pre-mRNA processing; removal of Flt-1 intron 13 by splicing produces the mRNA …
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Evaluating the role of PLGF and VEGFR-1/ Flt-1 in the development of cervical intraepithelial neoplasia and invasive cervical carcinoma in the background of HIV infection in women living in South Africa
… vascular endothelial growth receptor (VEGFR1/Flt-1), has been implicated in cervical carcinogenesis, yet their expression patterns across lesions to disease are poorly characterised. This study evaluated the expression patterns of PLGF and its receptor VEGFR1/Flt-1 across cervical …
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Evaluating the Expression of Angiogenic Mediators in a Mouse Model of Tumor Metastasis
… on host endothelial cells. One such receptor, Flt-1, occurs as either a membrane bound or a secreted form (sFlt-1) that can inhibit angiogenic signaling. Previous studies have shown that variation in mRNA expression of VEGF and its receptors KDR, sFlt-1 and Flt-1 occurs in pathological …
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Regulation von Faktoren der Angiogenese durch die kurzkettige Fettsäure Butyrat
… Agens und dessen zugehörigen Rezeptor FLT-1. Zudem wurde das Tumorsuppressorgen p53, ein wichtiger Modulator der Tumorentstehung und Tumorprogression, mituntersucht. Ziel war es, die positiven Effekte im Rahmen der Prävention auf die metastasierten kolorektalen Karzinome bzw. derer …
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Effects of Recombinant Endothelial Growth Factor 121 Therapy on Maternal Vascular Function and Vascular Fetal Programming in a Mouse Model of Preeclampsia
… 1, or soluble fms-like tyrosine kinase1 (sFlt-1). The soluble Flt-1 is generated by differential mRNA splicing of VEGF receptor 1. Soluble Flt-1 acts as a potent antagonist of VEGF and PlGF by preventing them from binding to their endothelial cell receptor, VEGFR-1 and VEGFR-2. Recently, we …
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Effects of Recombinant Endothelial Growth Factor 121 Therapy on Maternal Vascular Function and Fetal Vascular Programming in a Mouse Model of Preeclampsia
… 1, or soluble fms-like tyrosine kinase1 (sFlt-1). The soluble Flt-1 is generated by differential mRNA splicing of VEGF receptor 1. Soluble Flt-1 acts as a potent antagonist of VEGF and PlGF by preventing them from binding to their endothelial cell receptor, VEGFR-1 and VEGFR-2. Recently, we …
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Angiogenetische Faktoren bei Psoriasis, Ulcus cruris venosum und Dermatoliposklerose
… Nachweis einer gesteigerten Reaktivität für Flt-1, KDR und Tie-2 im Vergleich zur Normalhaut. In der RT- PCR zeigte sich eine deutliche Zunahme der Transkripte für Tie-2, Ang-1 und Ang-2 in psoriatischen Biopsien vergleichend zur Normalhaut. Wir vermuten, dass die psoriatische …
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Von Hippel-Lindau Syndrome: Characterization of a Potentially Novel VEGF-A Isoform and Elucidation of Molecular and Vascular Mechanisms of Observed Phenotypic Changes
… with excision of the VEGF Receptor-1 (VEGFR-1)/Flt-1 binding domain, rendering this isoform resistant to native down-regulation. Additionally, phenotypic changes were observed in adult VHL mutant mice, specifically very red appearing extremities with prominently visible vasculature. In order to …
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Advanced Studies in Veterinary Anatomy: Angiogenesis in Caprine Reproductive Organs of Non-Pregnant and Pregnant Normal and Swainsonine-Treated Does
… and its receptors (fms-like tyrosine kinase, Flt-1 and kinase-insert domain-containing receptor, KDR) was measured using real-time quantitative PCR. Targets were detected in all studied tissues; however, levels of expression differed according to the stage of pregnancy. Expression of VEGF and …
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Untersuchungen zur Rolle des HIV-1-Tat-Proteins in der AIDS-assoziierten Vaskulopathie
… wobei die Regulierung über den VEGF-Rezeptor Flt-1 vermittelt wurde. Weitere Faktoren wie inflammatorische Zytokine (TNF-a, IL-1b, IFN-g und IL-2), angiogene Wachstumsfaktoren (bFGF und VEGF165) und Chemokine (IL-8, MIP-1a, IP-10, MCP-1 und SDF-1a) hatten keine hemmende Wirkung auf die …
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Charakterisierung von Knochenmark-generierten Makrophagen unter der Einwirkung von Vascular Endothelial Growth Factor
… Mit dem Nachweis der VEGF-Rezeptoren Flt-1 und Flk-1 sowohl auf RNA- als auch auf Proteinebene war die Voraussetzung für das Ansprechen von BMDM auf eine Behandlung mit VEGF gegeben. Um einen möglichen Einfluss von VEGF (0,2; 2 und 20 ng/ml) auf BMDM zu untersuchen, wurden die Zellen …
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Characterization of the expression of angiogenic factors in the feline placenta during development and in feline cutaneous squamous cell carcinoma
… PlGF, showed a marked increase toward term; Flt-1, which acts as a receptor or reservoir for PLGF and VEGF A, was also upregulated at late pregnancy. Increased ratios of PLGF:VEGF-A may contribute to LZ proliferation in the last trimester. These findings are consistent with the creation of a …
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Polymorphisms in the Flt1 gene and their relation to expression of the secreted Flt1 variant
… responses through two cell-surface receptors, Flt1 and Flk1. In addition to the transmembrane form of Flt1, the Flt1 gene also encodes a secreted, truncated form of the receptor (sFlt1) translated from an mRNA in which a portion of intron 13 is preserved. sFlt1 retains high affinity for VEGF …