Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Flow technology"”.
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Diverse Applications of Flow Technology in Discovery Chemistry
… the development of methods and applications of flow technology in discovery chemistry. The first two chapters highlight the use of several beneficial features offered by flow technology to increase the throughput, safety, and convenience of organic synthesis. The last two chapters describe the …
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The powerful combination of novel organosulfur methodology and continuous flow technology
… of novel methodologies in the form of continuous flow technology, FlowNMR, and FlowIR, as well as traditional batch techniques, to deliver powerful transformations based on organosulfur chemistry. The main objective of this work was the synthesis of key building-blocks for biologically relevant …
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Application of continuous flow technology to the expedient synthesis of isotopically substituted compounds
… to traditional synthetic techniques, continuous flow systems provide a superior route to the preparation of such molecules viz allowing the use of small, highly contained systems, stoichiometric quantities of reagents and generic methodology to deliver products in high yields and purities. The …
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Photochemical transformations of α-diazocarbonyl compounds in flow
… and an α-diazo-β-ketosulfone, under continuous flow photolysis. These photochemical transformations yielded 2,3-dihydrobenzofurans, γ- and β-lactones, oxazoles and Wolff rearrangement products indicating the synthetic versatility of these metal-free processes. Continuous flow technology was also …
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Cas protein diagnostics for pathogen nucleic acids
… function. We identified Cas proteins as the core technology to develop further and split ourselves into two teams - one focusing on a DNA target and one focusing on an RNA target. The Ajioka Lab was assigned to create a test for a DNA target and we selected Hepatitis B Virus to be our test case. …
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LIGHT-DRIVEN STRATEGIES FOR THE GENERATION OF N-OXAZOLIDINONE RADICALS AND THE SYNTHESIS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS
… conditions in batch and continuous-flow systems; and (B) the application of the photo-Favorskii rearrangement as a key step in the synthesis of active pharmaceutical ingredients (APIs) under continuous and scalable reaction conditions. In particular, Chapter 1 provides an overall …
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An analysis of engine assembly and component production behavior
This study analyses the information and material flow through a component manufacturing and turbine engine assembly system. The intent of this work was to understand the inefficiencies associated with the current system, and to propose solutions which would prove valuable to the entire value chain, …
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DEVELOPMENT OF FLOW PROCESSES FOR THE EFFICIENT AND SUSTAINABLE PREPARATION OF HIGH VALUE CHEMICALS
… this context, enabling technologies such as flow chemistry offer considerable advantages by providing more efficient and environmentally friendly approaches to the synthesis of fine chemicals and active pharmaceutical ingredients (APIs). This doctoral research aimed to develop sustainable and …
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AMIDYL RADICALS IN LIGHT PROMOTED REACTIONS
… a photochemical transformation exploiting the flow technology. Chapter 2 is focused on the results obtained and it is divided in four main topics plus an appendix (illustrated in Figure 1): Chapter 2.1 deals with the enantioselective addition of amidyl radicals to aldehydes employing an …
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Characterisation of the mechanisms of tumour-induced dysfunction of clonal T cell expansions in multiple myeloma
… 10 year survivors were proliferative. Phospho-flow technology was used to investigate the differences in cell signalling pathways between T cell clones of 10 year and non-10 year survivors. The dysfunction in these cells was related to the upregulation of the SMAD pathway, promoting T cell …
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Preparation and evaluation of polymer microspheres for enhanced lateral flow immunoassay: the case study for malaria
… of a new high capacity polymer microsphere technology, termed ReSyn, could be developed as viable detection reagents for lateral flow technology. This body of work outlines the development of this new high capacity polymer microsphere technology for suitability to flow on lateral flow …