Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Flow Synthesis"”.
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Automated Flow Synthesis of Biomacromolecules
… D proteins, and PNAs in biotechnological workflows remains rare. In this work, we report the development of strategies for rapid, reliable access to these synthetically challenging classes of biomacromolecules. Existing synthetic pipelines face two primary complications: long timelines and …
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Development of a continuous-flow synthesis of neostigmine methylsulfate and studies toward a continuous-flow synthesis of lisinopril
… we describe the development of a continuous flow synthesis of neostigmine methyl sulfate, an acetylcholinesterase inhibitor on the WHO list of essential medicines, and the transfer of the synthesis into a next-generation reconfigurable frame developed by our collaborators. Starting from …
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Catalyst immobilization techniques for continuous flow synthesis
… research and industrial settings. As continuous flow processes continue to gain traction in research labs and fine and pharmaceutical chemical processes, new opportunities exist for implementing previously difficult catalytic transformations. The major goal of this thesis is to expand and …
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Annular Flow Synthesis and Assembly of Two-Dimensional Materials
… been suggested to play dominant roles in wet synthesis, but have not been properly explored. Here I developed new methods to both synthesize and analyse inorganic and metal-organic two-dimensional materials, using a combination of microreactor technology and liquid cell transmission electron …
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Invention and implementation of technologies for continuous flow synthesis
In this thesis, I have optimized a synthesis of rufinamide an important epilepsy medication. This convergent synthesis generates two reactive intermediates in situ (aryl azide and propiolamide) and then combines them in a regioselective click reaction utilizing copper tubing as the catalyst. Next, …
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Enabling the use of unstable, hazardous reagents with continuous flow synthesis
… arylisocyanide starting materials, continuous flow chemistry is further demonstrated to provide safe and effective access to 2-arylindoles through in situ dehydration and cyclization of easy-to-handle 2-alkenyl-N-formylanilines. Laurel M. Heckman and Dr. Zhi He contributed equally to initial …
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IN BATCH AND IN FLOW SYNTHESIS OF QUATERNARY AMINO ACIDS/AMINO DERIVATIVES
In Batch and In Flow Synthesis of Quaternary Amino Acids/Amino Derivatives (nel pdf n. 2 )
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Continuous flow synthesis of colloidal semiconductor nanocrystals: towards autonomous experimentation for accelerated material discovery
… the vast majority of work has focused on synthesis of semiconductor NCs containing toxic heavy-metal elements such as cadmium and lead. The inherent toxicity of heavy-metal-based colloidal NCs and the associated regulatory constraints have largely impeded their widespread implementation. …
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Synthesis and use of bench-stable precatalysts with heck-type activation and progress towards the continuous-flow synthesis of atorvastatin
… [color illustrations] Herein, we report the synthesis and characterization of a new class of air- and moisture-stable triphenylphosphine nickel(II) precatalysts, which activate through a Heck-type mechanism. The activity of these precatalysts is demonstrated with a carbonyl-ene coupling …
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Continuous processing of multiphase reactions for pharmaceutical applications
… of pharmaceutical manufacturing, the continuous flow synthesis has appeared as an attractive alternative to the conventional batch processes. Numerous technologies have emerged to facilitate the development of continuous flow chemistry, and the benefits of flow chemistry have been successfully …
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Photoredox activation of carbon dioxide and unactivated aliphatic carbonyl compounds
… Activation of Carbon Dioxide for Amino Acid Synthesis in Continuous Flow. Although carbon dioxide (CO₂ ) is highly abundant, its low reactivity has limited its use in chemical synthesis. In particular, methods for carbon-carbon bond formation generally rely on two-electron mechanisms for CO₂ …
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Robust Processes for Polymer Modification and Pharmaceutical Synthesis
… the development of a reactor for the continuous flow generation and use of dimethyldioxirane and its application to the low-level epoxidation of unsaturated polymers. A continuous stirred tank reactor prevents reactor clogging by allowing solid precipitates to settle, enabling the pumping of a …
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Developments and applications of methods for palladium- and copper-catalyzed carbon-nitrogen bond formation
… bond in the context of a biphasic continuous-flow system (Chapter 1). The second part of this thesis describes the recent developments of copper-hydride (CuH) catalyzed asymmetric hydroamination for the formation of a-chiral carbon(sp³)-nitrogen bonds from olefins. This work includes the …
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Design of Flow Reactors for the Continuous Synthesis of Nanoparticles
… protocol, the recommended method for the synthesis of Au NPs by the National Institute of Standards and Technology (NIST), is investigated in batch. The results challenge the traditional belief that the mechanism consists of a reduction reaction and a consecutive disproportionation …
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Flow Chemistry Guided by Computer-Aided Synthesis Planning
… practitioners outside the core field of organic synthesis to fully leverage these advances, in part due to lack of experience in planning and executing synthetic sequences as well as often times incomplete communication of procedural information known only to expert practitioners. New tactics for …
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Experimental and theoretical investigation of indium phosphide quantum dot growth mechanisms
… reactivity on the QD growth. High-pressure flow conditions allow for precise control of synthetic parameters and also the use of low-boiling-point solvents for synthesis with enhanced mixing. Results showed that lowering the precursor reactivity did not significantly improve the QD quality, …
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Continuous flow platforms for the synthesis of high-quality semiconductor nanocrystals
… these nanoparticles are produced via batch synthesis routes that suffer from various issues, including slow mixing, slow heating/cooling, and lack of batch-to-batch reproducibility. These issues escalate further when increasing the scale of the production, thereby hindering their application …
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Automated Execution and Optimization of Flow Chemistry on a Robotic Platform with Integrated Analytics
… characterization of chemical processes for the synthesis of organic compounds, which play a key role in society as medicines and materials, is currently an expensive and laborious enterprise. These inefficiencies are driving efforts to develop automated, data-rich experimentation (DRE) platforms …
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Fast flow biopolymer synthesis
… the development and application of fast flow solid phase synthesis for the preparation of peptides and phosphorodiamidate morpholino oligomers (PMOs), as well as the application of fast, reliable peptide synthesis to study non-natural protein folding and function. In the first chapter, …
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Integrated continuous-flow chemistry enabled by multistage separations
Flow chemistry is becoming an accepted method of continuous synthesis with its considerable advantages over batch chemistry, such as smaller infrastructure, faster production, and safer operation for aggressive reactions or extreme conditions. However, to realize the full benefits of flow chemistry …
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