Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"Flow Chemistry"”.
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Flow Chemistry Guided by Computer-Aided Synthesis Planning
Synthetic organic chemistry provides access to valuable materials and molecules that enable advancements across scientific disciplines. New advancements in synthetic technology continue to push the boundaries of how rapidly and efficiently complex matter can be produced. Despite this, it is often …
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Integrated continuous-flow chemistry enabled by multistage separations
Flow chemistry is becoming an accepted method of continuous synthesis with its considerable advantages over batch chemistry, such as smaller infrastructure, faster production, and safer operation for aggressive reactions or extreme conditions. However, to realize the full benefits of flow chemistry …
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Novel pump for flow chemistry applications with increased reliability
… at medium pressure (100-300 psi) and a low flow rate (less than 50 mL/min) have proven unreliable. The most common failures observed have been check valve failure and insufficient chemical compatibility. Some of these pumps use dual reciprocating pistons to drive the fluid, requiring the use …
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Advances in Heterocyclic Synthesis through Ring Expansions and Flow Chemistry
… of an Azasteroid Library. Ring expansion chemistry is a powerful way of introducing a heteroatom substituent into carbocyclic frameworks. However, such reactions are limited by the tendency of a given substrate to afford only one of the two rearrangement products or fail to achieve …
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The development of a multistage centrifugal pump for use in flow chemistry
Flow chemistry is an emerging approach to chemical synthesis in which chemical processes are performed on reactants as they continuously flow through reactors. In order to drive such flows, low flow rate, high pressure pumps are used. The standard pump in use is the displacement pump. However, it …
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Design and implementation of an automated reconfigurable modular flow chemistry synthesis platform
Synthetic chemistry has been the driving force behind advances in pharmaceuticals, agricultural chemicals to advanced materials; however, these fields have struggled with a slow pace of discovery, limited reproducibility, and difficulty scaling promising new molecules. Current organic chemistry …
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Automated Execution and Optimization of Flow Chemistry on a Robotic Platform with Integrated Analytics
… a modular robotic platform for continuous flow synthesis was utilized for machine-assisted organic reaction development. An improved version of the platform was built with new capabilities including a Cartesian robot for fast and reliable pick-and-place, integrated process analytical …
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Control tools for flow chemistry processing and their application to the synthesis of bromodomain inhibitors
Flow chemistry and continuous processing techniques are now frequently used in synthetic laboratories, taking advantage of the ability to contain reactive or hazardous intermediates and to perform moderate scale-up processes for important compounds. However, only a limited number of methods and …
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Determination of optimal conditions and kinetic rate parameters in continuous flow systems with dynamic inputs
… and new technologies could revolutionize a chemistry laboratory. Flow chemistry is a technique that contrast with traditional batch chemistry in one aspect as a method that facilitates process automation and in small scales, delivers process improvements such as high heat and mass transfer …
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CONTINUOUS-FLOW STRATEGIES FOR THE PREPARATION OF ACTIVE PHARMACEUTICAL INGREDIENTS AND RELEVANT INTERMEDIATES
… the development and application of continuous-flow strategies for the synthesis of active pharmaceutical ingredients (APIs) and key intermediates, with the aim of improving reaction efficiency, safety, and scalability. The work focuses on the integration of modern synthetic methodologies with …
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Continuous processing of multiphase reactions for pharmaceutical applications
… of pharmaceutical manufacturing, the continuous flow synthesis has appeared as an attractive alternative to the conventional batch processes. Numerous technologies have emerged to facilitate the development of continuous flow chemistry, and the benefits of flow chemistry have been successfully …
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Quantitative modeling and characterization of hydrodynamics and transport in multiphase microreactors
On-chip flow chemistry synthesis has advanced rapidly in recent years as a fast and effective means to discover and screen suitable reaction candidates for continuous production. Among the many chemical reactions, multiphase reactions constitute a major category with important industrial …
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FROM BATCH TO FLOW: RETHINK THE WAY OF DOING CHEMISTRY
In this thesis, the application of flow chemistry to overcome batch limitations in the process development of organic reactions was explored. Specifically, novel and challenging protocols for the synthesis of APIs were investigated, with the aim to develop alternative synthetic methodologies, and a …
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EXPLORING UNPRECEDENT SYNTHETIC ROUTES FOR CHIRAL AMINO DERIVATIVES
… transition-metal catalysis, and continuous-flow chemistry. The work explores the synthetic potential of light-driven processes to access reactive open-shell intermediates under mild and sustainable conditions, enabling transformations that are difficult or inaccessible using conventional …
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Electrochemical and Photocatalytic Flow Strategies for Sustainable Substrate Oxidation
… and the advantages offered by continuous flow chemistry vis-à-vis improved light transmission, compatibility with multiphasic systems, and catalyst recyclability, have not been fully explored for this class of materials. In the first part of this thesis, different design strategies are …
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LIGHT-DRIVEN STRATEGIES FOR THE GENERATION OF N-OXAZOLIDINONE RADICALS AND THE SYNTHESIS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS
Recent advances in radical chemistry have opened new opportunities in synthetic methodology, enabling the resolution of challenges that more conventional methodologies have historically encountered. This PhD thesis work aims to investigate two different research topics as outlined in Figure I: (A) …
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Organic Synthesis: Taming Chemistry using Enabling Technologies
This thesis describes the application of flow chemistry to discovery and development of medicinal compound synthesis and new chemical methodologies respectively. It is divided into three distinct sections. The first section addresses a brief introduction to flow chemistry, highlighting the …
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Enantioselective synthesis of pretomanid & investigations of Raman spectroscopy for through-tube monitoring of reactions
… of Reactions [color illustrations] Continuous-flow chemistry has seen expansive growth and thus requires powerful new analytical techniques. The current commonly-used analytics involve inline analysis at a single point, which can hinder analysis. In this report, we demonstrate the utility of …
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Engineering polymeric hollow fiber membrane reactors for sustainable chemical transformation reactions
… the past decade, laboratory-scale continuous-flow processes have witnessed explosive developments and have attracted a great deal of interest with respect to the significance of the economic and environmentally-sustainable production of pharmaceuticals, fine chemicals, and agrochemicals, as …
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APPLY LADDER OF CHEMICAL CIRCULARITY: RECYCLING OF RARE EARTH ELEMENTS RECOVERED FROM ELETRONIC WASTE AS A CATALYST IN ORGANIC REACTION.
… catalysis, with a specific focus on continuous flow chemistry. The research extensively examines the Michael addition reaction between indoles and benzylidene malonates, employing these catalysts to achieve high reaction efficiency and selectivity. Additionally, a Diels-Alder cycloaddition was …
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