Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Flk1"”.
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Der Einfluss mechanischer Last auf das Potential multipotenter adulter Keimbahnstammzellen zur kardialen Regeneration
… für die effiziente Differenzierung der maGSCs in Flk1+ kardiale und vaskuläre Progenitorzellen unter Verwendung eines Co-Kultur-Systems mit OP9-Stromazellen etabliert werden. Weiterhin zeigte sich, dass das Co-Kultursystem die Differenzierung der maGSCs in kardiale, endotheliale und glatte …
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Resolving Cell Fate: Experimental, computational and mathematical methods in single cell transcriptomic analysis
… granularity. A comprehensive analysis of FLK1+ cells harvested from gastrulating murine embryos was performed. In-silico reconstruction of pseudo-temporal and pseudo-spacial relations were demonstrated. Using prior knowledge of known driver genes deeper substructure was revealed in …
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The Role of Snail Homolog 1 in Embryonic Stem Cell Differentiation
… other types of mesoderm, Snail's induction of Flk1+ endothelial cells is cell-intrinsic and independent of Wnt, BMP, and Activin signaling pathways. Based on the transcriptional profile of Flk+ sorted cells, we hypothesize that Snail selectively induces endothelium in a subset of ES cells that …
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Polymorphisms in the Flt1 gene and their relation to expression of the secreted Flt1 variant
… through two cell-surface receptors, Flt1 and Flk1. In addition to the transmembrane form of Flt1, the Flt1 gene also encodes a secreted, truncated form of the receptor (sFlt1) translated from an mRNA in which a portion of intron 13 is preserved. sFlt1 retains high affinity for VEGF and thereby …
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Synthesising executable gene regulatory networks in haematopoiesis from single-cell gene expression data
… at this stage. The emergence of blood from Flk1+ mesoderm was studied by single cell expression analysis of 3934 cells at four sequential developmental time points. A mechanistic model recapitulating blood development was reconstructed from this data set, which was consistent with known …
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The Role of Meis1 in Hematopoietic Development
… the induction of EMT in ESCs or the induction of Flk1<super>+</super> mesoderm, but that it may play a role rather in the survival of <italic>Mesp1</italic>–induced mesodermal cells.</p><p>Although a clear role for <italic>Mesp1</italic> in EMT and cardiovascular differentiation has been …
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Effects of Diethylstilbestrol on Murine Early Embryonic Stem Cell Differentiation Using an Embryoid Body Culture System
… the surface proteins of interest: oct4, c-Kit, Flk1, ERα, ERβ, CD45, Flt1, & VE-cadherin. Analysis & Results: Changes in surface marker gene expression between day 0 and day 16 of differentiation were analyzed using the RT-PCR threshold counts (CT) and the comparative threshhold cycle method. …