Global ETD Search
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Showing 1 to 5 of 5 for “"Flippase"”.
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Targeting phosphatidylserine exposure in pro-coagulant platelets.
… to the inner leaflet of the plasma membrane by flippase activity, preventing its exposure on the outer surface of unstimulated and pro-aggregatory platelets. In pro-coagulant platelets, a high cytosolic calcium signal results in the activation of the scramblase protein, TMEM16F, causing PS to …
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Das Cysteine-String-Protein in Drosophila melanogaster: Molekulare und funktionelle Analyse verschiedener CSP-Mutanten; Ein Modell zur räumlich und zeitlich kontrollierten CSP-Expression
… mit dem Versuch, mithilfe des UAS/Gal4- und des Flippase/FRT -Systems die CSP-Expression räumlich und zeitlich zu kontrollieren. Dazu wurde aufgrund von Datenbankangaben eine minimale FRT-Sequenz aus Oligonukleotiden mit entsprechenden Linkern konstruiert. Das gesamte Csp-Gen beziehungsweise die …
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The regulation of yeast homotypic membrane fusion by class C ABC transporters
… lipid translocation. The translocation or flippase activity can be monitored using fluorescently labeled lipids. In this study, we describe a FRET-based assay to follow the translocation of the rhodamine-labeled phosphatidylethanolamine (RH-PE) in a real-time assay. We found that there is …
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Screen design for Borrelia burgdorferi lipoprotein secretion pathway components using periplasmic protein capture and suppressor mutations
… in the outer membrane, and a lipoprotein “flippase”, which allows lipoproteins to pass through the outer membrane to the surface. To facilitate identification of these two hypothetical pathway components in functional screens, we embarked on two approaches. First, a mutational analysis of …
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Arabidopsis thaliana P4-type ATPases ALA4 and ALA5 are Necessary for Normal Cellular Elongation in Developing Vegetative Tissues and Rescue the Pollen Tube Deficiencies in Knockout ala6/7 Mutants
… of the P4 subfamily of P-type ATPases (lipid flippases) have been shown to incorporate specific lipids into cellular membranes, as well as flip lipids from one leaflet to another to create an asymmetric distribution of lipid head groups as well as membrane curvature. In Arabidopsis thaliana, …