Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Fli1"”.
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Identification of EWS-FLI1 Regions Necessary for Ewing Sarcoma Proliferation
… EWS and ETS family transcription factor. EWS-FLI1 (EF) is the most common translocation and codes for a novel transcription factor that combines the N-terminus of EWS, which contains LC domain comprised of tyrosine rich peptide repeats, and C-terminal portion of FLI1, which contains the ETS …
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Investigating the defects of postnatal global Fli1 deletion in a mouse model
… in SSc patients. In this study we characterize a Fli1flox/flox mouse with CAG Cre under the beta-actin promoter. Based on what has been previously described in mice with deletion of Fli1 in specific cell types, we predicted that global postnatal deletion of Fli1 will result in systemic fibrosis, …
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Identifying CDK8/19 as a Novel Regulator of EWS-FLI1 Function in Ewing Sarcoma
… ETS transcription factor. The translocation EWS-FLI1 accounts for 90% of Ewing sarcoma tumors and a large body of evidence suggests that EWS-FLI1, acting as an oncogenic transcription factor, is the main driver of proliferation in Ewing sarcoma. Targeted therapies for Ewing sarcoma that act …
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A Mechanistic Evaluation of the Role of Aneuploidy During Oncogenesis
… tissue tumor that is mainly driven by the EWS-FLI1 fusion oncogene. Here, we specifically investigate the molecular mechanism of one chr8 gain-driver gene, RAD21, in mitigating EWS-FLI1-induced replication stress and promoting oncogenesis. We find that the overexpression of RAD21 facilitates …
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Estudio de los coactivadores transcripcionales TAZ y YAP1 en el sarcoma de Ewing: Implicación en la progresión tumoral e interacción funcional con la proteína de fusión EWS-FLI1
… de TAZ/YAP1 y la proteína de fusión EWS-FLI1, que, junto con la activación de la vía Wnt, podría contribuir a un estado más invasivo (EWS-FLIbajo) en el reciente modelo de diseminación metastásica propuesto en SE. Dicho antagonismo podría ser explicado, al menos en parte, por la represión …
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Genomic Characterization of Adolescent and Young Adult Cancers: Investigation of Ewing Sarcoma Susceptibility and Chornobyl Thyroid Tumors
… the interplay between a somatic driver, EWSR1- FLI1, and a highly polymorphic GGAA microsatellite in the 6p25.1 EwS GWAS susceptibility locus, employing third generation long-read sequencing to explore the functional consequences of how the germline informs somatic alterations. We found that …
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Identification Of Effective New Drugs Combinations Exploiting The Ability Of trabectedin To Modulate Transcription
… characterized by the chimeric protein EWS-FLI1 (hallmark of this pathology), that alters the transcription of different genes. The five-year overall survival of patients with localized disease is approximately 70%; unfortunately the majority of patients with a metastatic disease have a poor …
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G-Protein-Coupled Estrogen Receptor-1 (GPER): A Potential Target For Xenoestrogens During Vertebrate Embryogenesis.
… in vivo imaging assays and transgenic zebrafish (fli1:egfp), we then demonstrated that G-1 exposure resulted in impaired cardiac morphology and performance as well as, at higher concentrations, early circulatory arrest. Similarly, embryonic exposure to reference xenoestrogens - genistein and …
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Characterization of Genome-Wide Binding of NUCLEAR-FACTOR I-X in Hematopoietic Progenitor Cells
… including pSTAT1, RUNX1, RAD21, STAT3, ETO2, FLI1, GATA2, LYL1, LDB1 and PU.1. We showed NFIX and PU.1 together target genes regulating hematopoietic cell adhesion, cell death and differentiation in hematopoietic cells. Our data support a model in which NFIX collaborates with PU.1 to regulate …