Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Flexstation"”.
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Novel Modulators of Human Sperm Motility
… Using calcium as a surrogate for motility, a Flexstation high-throughput screening assay (HTS) of 3312 drug discovery ion channel compounds was performed. The screen identified 14 hit compounds that increase intracellular calcium in human spermatozoa. This project investigated these compounds, …
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Endothelial NADPH oxidases as regulators of coronary microvascular dysfunction in diabetic cardiac remodeling
… ROS/O2 - production, intracellular Ca2+ release (Flexstation) and cytokine release (cytokine array) in response to normal glucose (NG; 5.5mM) or high glucose (HG; 25mM). Experiments were repeated in coronary microvascular ECs (CMECs) to study differences in macro- vs. microvascular function. 3T3 …
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Role of P2Y12 receptor-mediated ADP signalling at microglia in the phagocytosis of neurons
Despite the prevalence of neurodegenerative disorders such as Parkinson’s and Alzheimer’s diseases, surprisingly little is known about the molecular mechanisms governing widespread neuronal loss observed in these conditions. Recent studies, however, have linked heightened microglial phagocytosis of …