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Showing 1 to 20 of 44 for “"Flavonol."”.
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HORMONE AND FLAVONOL REGULATION OF MAMMALIAN METABOLIC SIGNALING PATHWAYS
The incidence of obesity is increasing around the world. Obesity is often associated with debilitating diseases including Type 2 Diabetes Mellitus (T2DM). Both obesity and T2DM are linked to altered peptide hormone signaling, including insensitivity to insulin and leptin. Research in this …
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Flavonol kaempferol in the regulation of glucose homeostasis in diabetes
… strategy to prevent this disease. Kaempferol, a flavonol present in various medicinal herbs and edible plants, has been shown to elicit various pharmacological activities in preclinical studies. However, studies investigating the effect of kaempferol on diabetes are limited. In this dissertation, …
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THE INTERPLAY BETWEEN ETHYLENE SIGNALING AND FLAVONOL ANTIOXIDANTS IN MODULATING STOMATAL MOVEMENT AND ROOT ARCHITECTURE
… the effects of ethylene-induced accumulation of flavonol antioxidants on modulating stomata closure. Chapter 4 focuses specifically on the targets of ethylene-regulated gene expression and the role of the individual receptor isoforms in modulating root architecture. Combined, these chapters …
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Analysis of two single trait loci affecting flavonol glycoside accumulations in Arabidopsis thaliana natural variations
… modification and/or accumulation of different flavonol derivatives. The probable mechanism for generating variants of the enzymes is by mutating the corresponding genes. Therefore, Arabidopsis thaliana wildtype accessions collected from different environments and locations may have differences …
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Exploring hetero-atom derivatization in maltols and flavonols : the effect on reactivity of flavonol dioxygenation.
Flavonols are a class of polyphenolic natural products containing a 3-hydroxy pyrone core. They have been found to have several desirable properties such as anti-fungal, anti-bacterial, anti-mutagenic and anti-carcinogenic properties and they act as UV filters in plants. Flavonols display dual …
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Evaluation of the antioxidant activity of extracts and flavonol glycosides isolated from the seed coats of coloured beans (Phaseolus vulgaris L.)
… the functional food and nutraceutical industry. Flavonol glycosides were identified from acetone extracts of seed coats of black beans, pinto beans, and dark and light red kidney beans, representing nine varieties grown in Manitoba. Based on HPLC-MS/MS, black beans contained the 3-O-glycosides of …
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Examination of 2-Oxoglutarate Dependant Dioxygenases Leading to the Production of Flavonols in <i>Arabidopsis thaliana</i>
The flavonols are a varied and abundant sub-class of flavonoids that are associated with a number of essential physiological functions in plants and pharmacological activities in animals. The 2-oxoglutarate-dependant dioxygenases(2-ODDs), flavonol synthase (FLS) and flavanone 3-hydroxylase (F3H), …
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Expression and Biochemical Function of Putative Flavonoid GT Clones from Grapefruit and Identification of New Clones using the harvEST Database.
… detectable amounts of activity with quercetin, a flavonol; however, activity was lower than what would be expected if this enzyme were a flavonol-specific GT. In an additional aspect of this study, bioinformatics were used to test the hypothesis that additional putative GT clones could be …
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Molecular and biochemical characterization of hydroxyjasmonate and flavonoid sulfotransferases from Arabidopsis thaliana
… In contrast with the previously characterized flavonol 7-ST from Flaveria bidentis that sulfonates only flavonol disulfates, AtST3a was found to accept a number of flavonols and flavone aglycones, as well as their monosulfate derivatives. The AtST3a is expressed only at the earlier stage of …
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Encapsulación de flavonoles en ciclodextrinas. Efectos en su actividad antioxidante
1. Los tres flavonoles estudiados, miricetina, quercetina y kaempferol, pueden ser complejados en CDs, aumentando su solubilidad acuosa por la formación de complejos 1:1. 2. La complejación de miricetina, quercetina y kaempferol en CDs, provoca una variación en la intensidad de fluorescencia de los …
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Assessment of the spatial variability of vegetative status in vineyards using non-destructive sensors: Application of remote and proximal sensing technologies in precision viticulture
… and on-the-go, to determine chlorophyll, flavonol and nitrogen content in grapevine leaves. Materials and methods: A multispectral sensor mounted on a RPAS was employed for monitoring the spatial variability of the vegetative status of a commercial vineyard (Vitis vinifera L.) and the …
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The flavonoids of Umbellularia californica (lauraceae)
… representing a relatively simple profile of flavonol glycosides. Virtually no differences in profile were seen between the two forms. It was concluded that the flavonoid data do not provide any help in defining infraspecific taxa. The flavonoid profile identified in U. californica is …
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Immunomodulation of Flavonoid Biosynthesis in Transgenic Arabidopsis thaliana
… for anthocyanin accumulation and a reduction in flavonol glycosides in seedlings. Strong corroborating evidence that implicated the binding of scFv to CHI in the phenotypic alterations was obtained from protein mobility shift assays. Taken together, the results indicate that scFv-mediated …
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Amorphous solid dispersion effects on in vitro solution concentrations of quercetin
Quercetin is a flavonol with potential health benefits including activities against cardiovascular disease, obesity, and oxidative stress. However, the benefits of quercetin are likely limited by poor bioavailability, primarily attributed to its poor aqueous solubility (due to its hydrophobicity …
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Mechanisms of Enzyme Neofunctionalization in Plant Specialized Metabolism
… for gene duplication and neofunctionalization of flavonol synthase (FLS) that led to the unique emergence of halogenase in Menispermaceae plants. The discovery of dechloroacutumine halogenase (DAH) that catalyzes the regio-stereoselective chlorination in acutumine biosynthesis, exemplifies a mode …
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Effects of Polyphenols on Vasomodulatory Factors and Associated Cell Signalling
… HUVECs were treated with quercetin, a flavonol found in a number of the plant extracts, alongside a mix of its human metabolites to assess their effect on a broad range of phosphorylated proteins using an antibody microarray. Quercetin (50 μM) significantly decreased eNOS …
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Investigation of the fate of dietary flavonols in humans and rats using HPLC-MS2 techniques
… Onions are a rich source of the polyphenolic flavonol quercetin-4′-glucoside. For this compound to have some health effects it must be absorbed and reach target organs in a concentration and form where they can exert an effect. To-date interest has focussed on the levels of the intact …
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Metabolism in Vascular Endothelial Cells: Effects of Hyperglycaemia, Pro-Inflammatory Cytokines and Polyphenols
… and period of exposure. Pre-treatment with the flavonol quercetin significantly reduced CAM expression in HUVECs. Next, the ability of quercetin to overcome the pro-inflammatory effects of hyperglycaemia and cytokine treatments in HUVECs was investigated using a metabolomics approach with a view …
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