Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 23 for “"Flaviviridae"”.
-
Genetic and Biochemical Analyses of the Flaviviridae Capsid Proteins
<p>The small, enveloped viruses of the family Flaviviridae are etiological agents of numerous important human and agricultural diseases including hepatitis C, yellow fever, and bovine viral diarrhea. Efficient dissemination of these viruses is dependent on the production of infectious particles, …
-
The Structural Basis of Flaviviridae Interaction with Antibodies and Receptors
Flaviviridae are a family of enveloped, positive-stranded RNA viruses responsible for a variety of diseases including encephalitis, hemorrhagic fever and hepatocellular carcinoma. The envelope: E) proteins that coat the outer surface of these viruses provide the molecular machinery that drives …
-
Assessing and understanding the generation and function of RNA decay intermediates in non-insect borne flaviviruses
… translation. Members of the viral family Flaviviridae are positive sense, single-stranded RNA viruses that do not possess a poly(A) tail. Therefore, it is highly likely that these transcripts would be marked as deadenylated and shuttled down one of the RNA decay pathways that exist in the …
-
Strukturní a funkční charakterizace inhibice flavivirové methyltransferázy.
Viry rodu flavivirus, patřící do rodiny Flaviviridae, jsou rozšířenou skupinou virových patogenů, které představují globální hrozbu pro lidské zdraví. Následky infekce jsou neurologické nebo jiné onemocnění jako je encefalitida, meningitida, mikrocefalie nebo krvácivá horečka, přičemž přímá …
-
The Interferon Stimulated Gene Product Lymphocyte Antigen 6 Complex, Locus E Promotes Entry of a Subset of Diverse RNA Viruses and Inhibits Infection by Coronaviruses
… screen to enhance the infection of viruses from Flaviviridae, Orthomyxoviridae, Retroviridae, and Alphaviridae viral families. In my studies, I confirmed that LY6E promotes viral infection of viruses from the same families, as demonstrated by both ectopic overexpression and endogenous knockout …
-
Molecular Evolution of Viruses
… polyprotein sequences from the viral family Flaviviridae, the CGR method was able to cluster members of major viral groups together, but relations within groups were not well resolved in comparison to an alignment-based phylogeny. We applied the method to members of five different families of …
-
Dissecting the Entry Pathways of Hepatitis C and Bovine Viral Diarrhea Viruses
… (BVDV) are closely related members of the family Flaviviridae and are important human and animal pathogens, respectively. In this work, I investigated how these viruses interact with and enter both naïve and previously infected cells, specifically, the mechanisms of superinfection exclusion, the …
-
Ρύθμιση της έκφρασης του IRES (εσωτερική θέση πρόσβασης του ριβοσώματος) του ιού της ηπατίτιδας C
… ανήκει στο γένος Hepacivirus της οικογένειας των Flaviviridae. Έξι γονότυποι ( 1-6 ) είναι γνωστοί, καθένας από τους οποίους μπορεί να υποδιαιρεθεί περαιτέρω σε αρκετές υποτύπους. Το γονιδίωμα του HCV αποτελείται από ένα μεγάλο ανοικτό πλαίσιο ανάγνωσης (ORF), πλαισιωμένο από ιδιαίτερα δομημένες 5 …
-
Thioaptamers Targeting Dengue Virus Type-2 Envelope Protein Domain III
… is an arbovirus that belongs to the family of Flaviviridae, genus Flavivirus. It includes Dengue virus (DENV) types 1-4, West Nile virus, Langat virus, Omsk hemorrhagic fever virus and others that cause encephalitic or hemorrhagic disease. DENV binds the cell surface receptors and fuses with …
-
Countermeasures Against Viral Hemorrhagic Fevers
… Filoviridae, Arenaviridae, Bunyaviridae, and Flaviviridae. All these viruses are enveloped and contain a single-stranded RNA genome. However, the viruses differ in their pathogenesis, transmissibility, natural host, and geographical distribution. VHFs usually begin presentation with marked …
-
Mutational analysis of the West Nile Virus NS4B protein
… a member of the genus Flavivirus in the family Flaviviridae. The WNV genome is a positive-sense RNA molecule approximately 11kb in length encoding a single polyprotein that is cleaved by a combination of viral and host proteases to produce three structural and seven nonstructural proteins. The …
-
Structural and Biochemical Characterization of N-Terminal Protease of Classical Swine Fever Virus
… positive sense RNA viruses that belong to the flaviviridae family. They express their genome as a single polypeptide that is subsequently cleaved into individual proteins by host- and virus-encoded proteases. N-terminal protease Npro is the first translated protein of the pestivirus genome. …
-
Progress Towards Integrated Models of HCV Dynamics
… enveloped positive-strand RNA member of the Flaviviridae and the etiological agent of a global epidemic of chronic hepatitis C. One of the salient features of HCV is a complex regulatory scheme involving numerous viral and cellular components and which may be the key to its striking success …
-
Determining the Pathogenesis and Enzootic Transmission of Usutu Virus
… (USUV) is an emerging zoonotic virus within the Flaviviridae family that can cause neurological disease in humans and wild birds. USUV is maintained in an enzootic cycle between wild birds, primarily passerine species, and ornithophilic mosquitoes, predominantly Culex spp. mosquitoes. Since its …
-
Identification of hepatitis C virus core protein residues critical for the interaction with the cellular DEAD-Box Helicase DDX3 and their functional relevance
… is a single-stranded RNA virus belonging to the Flaviviridae and infects approximately 170 million people worldwide. Unlike other known RNA viruses, HCV causes a persistent infection in the majority of infected people and can lead to cirrhosis of the liver and hepatocellular carcinoma. For these …
-
Usutu Virus: An Emerging Arbovirus Threat
… Usutu virus (USUV; Genus: Flavivirus; Family: Flaviviridae) is one such pathogen currently causing mass die-offs of avian hosts throughout Europe. USUV is categorized in the Japanese Encephalitis virus (JEV) antigenic complex and thus shares many antigenic and pathologic characteristics with …
-
West Nile virus vaccination protects against Usutu virus disease in mice
… and WNV; both have RNA genomes and belong to the Flaviviridae virus family. Both WNV and USUV were initially isolated in Africa and have since spread to Europe; interestingly, WNV has also spread globally and is considered endemic in the Americas. Similar to other flaviviruses, USUV and WNV are …
-
Dissecting the Novel Roles of TRIM56 in Antiviral Innate Immunity
… virus, a ruminant pestivirus of the family <em>Flaviviridae</em>, but has no appreciable effect on VSV, a rhabdovirus. We have also shown that TRIM56 forms a complex with the Toll-like receptor-3 (TLR3) adaptor, TRIF, via its C-terminal residues 621-750, and augments TLR3-mediated interferon …
-
Control and mitigation of bovine viral diarrhoea in Australian cattle populations.
… a member of the genus Pestivirus in the family Flaviviridae, closely related to Border Disease Virus and Classical Swine Fever Virus. An increased incidence and severity of secondary disease and potentially dramatic reproductive loss associated with BVDV infection results in ongoing financial …
-
The role of mosquito saliva on host immune response and pathogenesis of West Nile virus\r\n
… sense single-stranded RNA virus in the family Flaviviridae that emerged globally following the appearance of a more neurotropic subtype. Recently outbreaks of WNV disease have occurred in the Middle East, Europe, Africa, South America, and North America. Vertebrates typically become infected …
Page 1 of 2