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Showing 1 to 20 of 26 for “"Flavin Mononucleotide"”.
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A Study of Flavin Mononucleotide Electrochemistry
Made available in DSpace on 2014-12-09T17:35:27Z (GMT). No. of bitstreams: 1 6604321.pdf: 3589705 bytes, checksum: 0e24183ca3fa7c0fa69f456c551ca95d (MD5) Previous issue date: 1965
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An Electrochemical Study of the Adsorption Behavior of Flavin Mononucleotide at a Mercury Electrode
Made available in DSpace on 2015-05-12T22:35:26Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7206854.PDF: 4736911 bytes, checksum: 2dabcac17c62eaeda710f3bf7c1cb3d3 (MD5) Previous issue date: 1971
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Unraveling the mechanism of the lightstruck flavor of beer
… in a light-induced reaction involving riboflavin as a sensitizer (riboflavin is the main flavin in beer), isohumulones (hop-derived, beer-bittering compounds), and a sulfur source (e.g. cysteine or sulfur-rich proteins). The off-flavor was attributed to formation of …
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Quantum Mechanical/molecular Mechanical Studies of F(1)-Atpase and a Plant Photoreceptor
… permitted us to characterize the pathway for flavin-cysteinyl adduct formation, which was found to proceed via a neutral radical state generated by hydrogen atom transfer from the reactive cysteine residue, C57, to the chromophore flavin mononucleotide. Interestingly, we find that adduct …
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Amino Acid Sequence Studies on the Beta Subunit of Bacterial Luciferase
… including regions and residues implicated in flavin binding by these enzymes. Therefore, our data do not suggest a role for the (beta) subunit in binding reduced flavin mononucleotide, but they do support the view that luciferase is significantly different from all other flavin monoxygenases.
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Stimulated emission from biological materials and novel optical resonators for diagnostic and imaging applications
… and polarization characteristics for the flavin mononucleotide biomolecular laser, is presented here. In addition, our investigation of natural, bio-engineered, and complex biological laser systems culminates in the discovery of a phycobiliprotein laser, a 30% reduction in threshold energy …
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Influence of Iron Speciation on Redox Cycling and Reactivity With Persistent Organic Contaminants
… solutions containing a biogenic reducing agent, flavin mononucleotide (FMN), was also investigated. Results of kinetic studies show that FeIII-DFOB complexes are reduced to the corresponding FeII complexes by the fully reduced hydroquinone form of FMN (FMNHQ) over a wide pH range. Reaction rates …
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Spectroscopic Technologies and Computational Approaches for Real-Time Detection of FMN as Biomarker during Machine Perfusion
… of technologies for the real-time detection of Flavin Mononucleotide (FMN), considered a biomarker of ischemia-reperfusion injury, during organ perfusion. The methodologies employed are based on spectrophotometric measurements, UV-visible absorption, and fluorescence, using both standard …
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Higher-Order Assemblies of Flavin-Wrapped, Single-Walled Carbon Nanotubes
… nanotube based on the helical self-assembly of flavin mononucleotide (FMN) and its significantly higher affinity for the (8,6) nanotube[<a title="Ju, 2008 #7">3</a>]. In process of understanding the mechanism and favorability of (8,6) selection, it was discovered that FMN-nanotubes form novel, …
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Structure and Mechanism of a Eukaryotic FMN Adenylyltransferase
Flavin mononucleotide adenylyltransferase (FMNAT) catalyzes the formation of the essential flavocoenzyme FAD and plays an important role in flavocoenzyme homeostasis regulation. By sequence comparison, bacterial and eukaryotic FMNAT enzymes belong to two different protein superfamilies and …
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A Computational Investigation of the Mechanism of CB1954 Reduction by E.coli Nitroreductase
… geometry for the hydride transfer from the FMN (flavin mononucleotide) cofactor of NTR to a nitro group of CB1954. Additionally, three reaction profiles were generated which suggest that in the gas phase, the reduction proceeds by electron transfer from FMN, proton transfer , then second proton …
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Ablation of Retbindin, the Riboflavin Binding Protein, Exacerbates Retinal Degenerative Phenotypes in Mouse Models of Human Retinal Diseases
Retbindin (Rtbdn) is a retina-specific, riboflavin binding protein, expressed only by the rod photoreceptor cells. Riboflavin is the precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) which are essential co-factors for enzymes involved in wide-range of metabolic …
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Cryo-electron microscopy studies on ovine mitochondrial complex I
… cardiolipins). The hydrophilic arm harbours flavin mononucleotide and 8 iron–sulfur clusters involved in electron transfer. Supernumerary subunits build a scaffold around the conserved core, strongly stabilizing the complex. Additionally, subunits containing cofactors (NADPH, zinc ion and …
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Biophysical and structural studies of novel F420-dependent oxidoreductases in Mycobacterium tuberculosis
… Rv2074, Rv3369c, Rv1875, Rv0121c. PNPOx is a flavin mononucleotide (FMN)-dependent enzyme involved in the biosynthesis of the crucial cofactor, pyridoxal 5’- phosphate (PLP). The work presented in this thesis shows that while Rv2607 exhibits canonical PNPOx activity, Rv1155 and Rv2991 do not …
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Structural and functional studies of mitochondrial NADH:ubiquinone oxidoreductase (complex I)
… I from bovine heart mitochondria. First, the flavin mononucleotide, the site of NADH oxidation, was identified as the site of the ‘inhibitor-insensitive’ NADH:ubiquinone oxidoreduction reaction. The formation of semiquinones initiates redox cycling reactions with oxygen, producing vast amounts …
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Targeted depletion of RibF, a putative bifunctional FAD synthetase/ flavokinase in Mycobacterium smegmatis using CRISPR interference
… ribF, an essential gene in the mycobacterial riboflavin (RF; vitamin B2) biosynthetic pathway. Given the role of RF as a core component of the essential flavin cofactors, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), it was hypothesized that silencing ribF would disrupt the …
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Mechanistic Insights into MftR-Dependent Regulation of the Redox Cofactor Mycofactocin
… cofactors are essential for life. While classic flavins and nicotinamides are widely distributed across all domains of life, nature has also evolved niche cofactors in subsets of life domains. For example, in <em>Actinobacteria</em>, coenzyme F420 is commonly used in place of flavin …
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Role of Hydroxy acid oxidase 2 (Hao2) in hepatocellular carcinoma
Background: Hydroxy acid oxidases are flavin mononucleotide (FMN)-dependent peroxisomal enzymes. Although it is unclear whether 2-hydroxy acid oxidases contribute to a general mechanism of fatty acid α-oxidation, these enzymes are capable of oxidizing a broad range of 2-hydroxy acids, ranging from …
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Design of Iron Oxide-Flavin Nanocomposite Bacterial Cellulose Hydrogels
… nanoparticles (IONPs). When IONPs are coupled to flavins, naturally occurring photoactive isoalloxazine compounds, a heterogenous photocatalytic system is created that can integrate into BC, thus forming nanohybrid photoactive hydrogels. The hybrid gels have shown potential in their applicability …
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Long-range extracellular electron transport by dissimilatory metal-reducing bacteria across a physical separation
… Escherichia coli, and an exogenous supply of riboflavin. Riboflavin was found to act not as a diffusible electron shuttle, but as a bound redox cofactor. The high binding affinity of riboflavin reported for outer membrane c-type cytochromes (c-Cyts) suggests that riboflavin was bound to OmcS, a …
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