Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 122 for “"Flavin"”.
-
A Study of Flavin Mononucleotide Electrochemistry
Made available in DSpace on 2014-12-09T17:35:27Z (GMT). No. of bitstreams: 1 6604321.pdf: 3589705 bytes, checksum: 0e24183ca3fa7c0fa69f456c551ca95d (MD5) Previous issue date: 1965
-
Design and Application of Nanostructured Flavin Photocatalysts
Flavin compounds are found in Nature within a range of flavin-containing enzymes (flavoenzymes) that are responsible for metabolic, antioxidant and photoreception processes across animal, plant and bacteria kingdoms. Their broad redox and photochemistry has seen the field of flavin-based catalysis …
-
Flavin-dependent Enzymes in Natural Product Biosynthesis
… in natural product biosynthesis. The class B flavin-dependent monooxygenases S-monoooxygenase from Allium sativum (AsFMO) and N-hydroxylating monooxygenase from Streptomyces sp. XY332 (FzmM) were studied. Both enzymes perform heteroatom oxidation as part of allicin or fosfazinomycin …
-
Ultrafast Dynamics of Flavin Cofactor in Photolyase/Cryptochrome Family
… to study the photochemistry and photophysics of flavin cofactor. This dissertation presents a systematic investigation on the ultrafast dynamics of flavin cofactor in four redox states in photolyase/cryptochrome family proteins. In photolyase, the antenna molecule MTHF absorbs a photon and …
-
Design of Iron Oxide-Flavin Nanocomposite Bacterial Cellulose Hydrogels
… nanoparticles (IONPs). When IONPs are coupled to flavins, naturally occurring photoactive isoalloxazine compounds, a heterogenous photocatalytic system is created that can integrate into BC, thus forming nanohybrid photoactive hydrogels. The hybrid gels have shown potential in their applicability …
-
Higher-Order Assemblies of Flavin-Wrapped, Single-Walled Carbon Nanotubes
… nanotube based on the helical self-assembly of flavin mononucleotide (FMN) and its significantly higher affinity for the (8,6) nanotube[<a title="Ju, 2008 #7">3</a>]. In process of understanding the mechanism and favorability of (8,6) selection, it was discovered that FMN-nanotubes form novel, …
-
Mechanisms of Flavin-Dependent Monooxygenases Involved in Natural Product Chemistry
… products. Each of these enzymes belong to the flavin-dependent monooxygenase (FMO) family, which catalyze the oxygenation of a substrate, generating an oxidized product. ZvFMO, from the insect food crop pest, Zonocerus variegatus, was determined to catalyze a highly uncoupled oxygenation …
-
Biochemical characterization of Aspergillus fumigatus SidA: a flavin-dependent N-hydroxylating enzyme
… Af SidA forms a stable C4a-(hydro)peroxyflavin intermediate that is stable on the second time scale. Af SidA is also inhibited by several halides and the arginine-reactive reagent, phenylglyoxal. Biochemical comparison of Af SidA to other flavin-containing monooxygenases reveal that Af …
-
Biochemical Characterization of Thermocrispum agreste TheA: A Flavin-Dependent N-hydroxylating Enzyme
N-hydroxylating monooxygenases (NMOs) are Class B flavin-dependent monooxygenases found only in fungi and bacteria. These enzymes catalyze the hydroxylation of nucleophilic primary amines, such as those found in histamine, L-ornithine, L-lysine, and small aliphatic diamines. The hydroxamate moiety …
-
Stereoselectivity, kinetics, and engineering of flavin/deazaflavin oxidoreductases for use in industrial biocatalysis
… operating conditions. Due to their unusual deazaflavin cofactor, F420, the flavin/deazaflavin oxidoreductase (FDOR) family have attracted attention as potential biocatalysts. A low-potential obligate hydride donor with chemistry more akin to nicotinamides than conventional flavins, F420 plays a …
-
Stereoselectivity, kinetics, and engineering of flavin/deazaflavin oxidoreductases for use in industrial biocatalysis
… operating conditions. Due to their unusual deazaflavin cofactor, F420, the flavin/deazaflavin oxidoreductase (FDOR) family have attracted attention as potential biocatalysts. A low-potential obligate hydride donor with chemistry more akin to nicotinamides than conventional flavins, F420 plays a …
-
Characterisation of the flavin adenine dinucleotide binding region in Myxococcus xanthus protoporphyrinogen oxidase
… IX to protoporphyrin IX, in the presence of flavin adenine dinucleotide (FAD) and oxygen. FAD is a cofactor, functioning as an intermediate electron acceptor in the catalytic function of PPOX. In this study the FAD binding region in Myxococcus xanthus PPOX was analysed by engineering and …
-
Mechanistic Studies of Flavin-Dependent Monooxygenases Involved in Bacterial Defense and Plant Metabolism
Flavin-dependent monooxygenases (FMOs) are a large family of enzymes found in microbes, plants, animals, and humans involved in defense pathways, xenobiotic metabolism, and natural product biosynthesis. One class of FMOs, Class B, carries out the oxidation of heteroatomic substrates, via …
-
Flavin Amine Oxidases from the Monoamine Oxidase Structural Family Utilize a Hydride Transfer Mechanism
… and steady-state kinetic analyses of two flavin amine oxidases, mouse polyamine oxidase (PAO) and human lysine specific demethylase (LSD1), to determine the mechanisms of amine oxidation. PAO is a flavin adenine dinucleotide (FAD)-dependent enzyme that catalyzes the oxidation of …
-
An Electrochemical Study of the Adsorption Behavior of Flavin Mononucleotide at a Mercury Electrode
Made available in DSpace on 2015-05-12T22:35:26Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7206854.PDF: 4736911 bytes, checksum: 2dabcac17c62eaeda710f3bf7c1cb3d3 (MD5) Previous issue date: 1971
-
Structural and Mutational Analyses of Aspergillus fumigatus SidA: A Flavin-Dependent N-hydroxylating Enzyme
SidA from Aspergillus fumigatus is an N-hydroxylating monooxygenase that catalyzes the committed step in siderophore biosynthesis. This gene is essential for virulence making it an excellent drug target. In order to design an inhibitor against SidA a greater understanding of the mechanism and …
-
Elucidation of the quinone methide tautomer of riboflavin and generation of a flavin nitroxyl radical
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1981.
-
Proline Utilization in Salmonella Typhimurium: A Model for Regulation of Peripheral-Membrane Flavin Dehydrogenase-Lipid Interactions
… toxicity by this peripheral membrane flavin dehydrogenase.
-
Studies on the Flavin Binding Properties of Native and Protease-Activated Pyruvate Oxidase From Escherichia Coli
Pyruvate oxidase, a tetrameric enzyme consisting of four identical subunits, dissociates into apoenzyme monomers and free FAD when treated with acid ammonium sulfate in the presence of high concentrations of potassium bromide. Reconstitution of the native enzymatically-active protein can be …
Page 1 of 7