Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Fixed-dose combination"”.
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Pricing and reimbursement challenges for fixed dose combination cardiovascular drugs and intravenous oncologies
… of drugs were chosen to examine this topic: fixed dose combination (FDC) cardiovascular drugs and intravenous oncologies. FDC cardiovascular drugs were chosen because they are covered under the pharmacy benefit / Part D and are considered to have questionable efficacious value over their …
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Development and Bioavailability/Bioequivalence of a Fixed-Dose Combination Antiretroviral Reconstitutable Suspension Intended for Pediatrics
… bioequivalence of age-appropriate fixed-dose combination granules of lamivudine/zidovudine/nevirapine as reconstitutable suspension for pediatrics for use in pediatric patients. The granules were developed via roller compaction process to improve granule flow characteristics, …
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Rates of Switching First-Line Antiretroviral Regimen Tenofovir-Emtricitabine-Efavirenz combination in a Primary Care Service in South Africa
… Tenofovir-Emtricitabine-Efavirenz (TEE) fixed-dose-combination (FDC) has been recommended since 2013 as the first-line antiretroviral therapy (ART) for treating HIV for people living with the virus (PLWH) in South Africa. More evidence has emerged to show long term adverse effects of …
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A scoping review on the use of telerehabilitation in physiotherapy in low and middle income countries
… a bacteriostatic drug, administered as part of a fixed-dose combination regimen for the treatment of tuberculosis (TB). Individuals with comorbid HIV have reported reduced serum concentrations of ethambutol. We aimed to evaluate the pharmacokinetics of ethambutol in individuals with both …
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Development of fixed dose combinations using advanced engineering technologies
… throughout this thesis in order to produce fixed-dose combination products. Depending on the desired characteristics of the final formulation, selection of appropriate continuous manufacturing platform had a critical impact on the overall outcome. Several continuous manufacturing platforms, …
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Incidence and Prevalence Of Renal Dysfunction In Antiretroviral Therapy (ART) Naïve Patients Starting A Tenofovir (TDF) Based ART Regimen In Mitchell's Plain Community Health Centre (CHC) ARV Clinic
… antiretrovirus (ARV) activity and available in fixed dose combination (FDC). However, it has been found to cause renal dysfunction. Objectives: To document the prevalence, incidence, pattern of occurence and associated factors of nephrotoxicity in patients initiated on TDF based ART regimen in …
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Identifying strategies to inform interventions for the secondary prevention of stroke in UK primary care
… medication taking for secondary prevention (i.e. fixed-dose combination polypill). Findings showed that survivors face considerable barriers to medicine taking, but that facilitators, particularly the caregiver role, can encourage good medication taking practice. The online forum has potential as …
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Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated Falciparum malaria
… 28 days in a therapeutic efficacy study of the fixed-dose combination therapy, artesunate-amodiaquine. RESULTS: The day 28 genotype-adjusted adequate clinical and parasitological response rate of artesunate-amodiaquine combination in 321 patients studied was above 97% in both the …
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Pharmacometrics of dolutegravir and tenofovir: a quantitative approach to characterise drug-drug interactions, pharmacogenetics and optimise treatment
… efavirenz- to dolutegravir-based regimens. A fixed-dose combination containing dolutegravir, tenofovir, and lamivudine taken daily constitutes one of the most widely used regimens in Africa. In this thesis, we employ population pharmacokinetic modelling to optimise HIV treatment using data …
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Strategies for optimising TB-HIV co-treatment in children and adolescents with drug-susceptible tuberculosis on rifampicin-based standard regimens
… recommendations for first-line TB drugs using fixed-dose combination tablets. Next, we examined two dose-adjustment strategies involving lopinavir/ritonavir, a widely available protease inhibitor for first- and second -line ART, using both liquid and tablet formulations. We then investigated a …
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Population/ Nonlinear mixed-effects modelling of pharmacokinetics and pharmacodynamics of tuberculosis treatment
… with the currently recommended weight-adjusted doses for drug-susceptible and -resistant tuberculosis. Concentration-time data from the RAFA study were used to characterise the pharmacokinetics of the four drugs of the fixed dose combination (FDC) therapy including desacetyl-rifampicin, and …
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RETROSPECTIVE DESCRIPTIVE STUDY ON POST-MARKET MEDICINE QUALITY-RELATED COMPLAINTS AND THE APPLICATION OF FIELD-BASED DETECTION OF POORQUALITY MEDICINES USING NEAR-INFRARED AND RAMAN SPECTROSCOPIC SCREENING METHODS
… including metronidazole, losartan, and a fixed-dose combination antiretroviral tenofovir/lamivudine/dolutegravir. Laboratory studies assessed the performance of handheld Near-Infrared (NIR) and Raman spectrometers on identical medicine samples. A chemometric workflow incorporating …
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Evaluating South African policies for linkage to and retention in HIV care using quasi-experimental methods
… whether the introduction of a single-pill fixed-dose combination (FDC) treatment for ART initiators in South Africa had an impact on attrition from care compared to the previously-recommended multiple-pill regimen. We focused on an urban clinic in Johannesburg, using four different clinic …
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Patient Friendly Formulations Utilizing Hot Melt Extrusion Technology
… tablet, fast disintegration films and fixed dose combinations. Previous research demonstrated these applications by conventional formulation techniques which has inherent shortcoming of use of large amount of solvent and batch size manufacturing. This present work addressed some of the …