Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"First-line drugs"”.
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Malaria treatment seeking behaviour and access to artemisinin combination therapy : a case of Mushin, Lagos, Nigeria
… malaria and are currently recommended as first-line drugs for the treatment of uncomplicated malaria in Nigeria because of resistance of malaria to chloroquine (CQ) and sulphadoxine pyrimethamine (SP). However, very little is known about malaria and treatment-seeking patterns and the use …
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The effects of anticholinesterases and β-amyloid pathology on neurotrophin signaling in the mouse brain
… brain-derived neurotrophic factor (BDNF). The first aim of this study was to examine the effects of cholinesterase inhibitors (ChEi), the first-line drugs for AD, on Trk neurotrophin receptor activity in the mouse brain. We show that donepezil and galantamine, two clinically used ChEis, rapidly …
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Investigation of anticancer activity and mechanisms of Meso- 2,3-dimercaptosuccinic acid (DMSA) in glioblastoma cell lines
… been working on repurposing known FDA approved drugs for cancer treatment. Previous studies from our group have shown that Disulfiram (DS), an FDA approved anti alcoholism drug has excellent anticancer activity against a wide range of cancers with its metal binding capability through its unique …
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Investigating the Role of RNA-Binding Proteins in Tumor Response to DNA Damage-Inducing Chemotherapy
… cytotoxic agents that induce DNA damage remain first-line drugs in the clinic. Unfortunately, the majority of patients will develop resistance to DNA-damaging chemotherapy and relapse. Recent studies indicate that RNA-binding proteins (RBPs) appear to play a particularly important role in …
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Three-Dimensional (3D) pharmacophore-based identification of possible ATP-synthase inhibitors for mycobacterium tuberculosis (Mtb)
… to fluoroquinolone as well as other second- line drugs (Capreomycin, Kanamycin and Amikacin). Bedaquiline (BDQ) is a diarylquinoline aimed at inhibiting the adenosine triphosphate (ATP) synthase of MDR-TB, thereby targeting the energy metabolism mechanism of Mtb. Drug regimens utilized prior …
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PLGA-DS reverses chemoresistance in malignant mesothelioma by targeting hypoxia induced cancer stem cells
… of fewer than 12 months, with less than five drugs available for its treatment. MM recurrence is unavoidable due to chemoresistance. Long-term inflammation triggered by asbestos activates a key transcription factor, nuclear factor-κB (NF-κB), which is further upregulated in cancer stem cells …
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The effect of stimulus threat on experimentally induced secondary hyperalgesia
… to pharmacotherapy. Numbers needed to treat for first line drugs range from 4 – 8. Therefore, there is an obvious need for improved understanding of the mechanisms of neuropathic pain to inform improved treatments. Mechanistic research on neuropathic pain frequently uses a human surrogate model …
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Advancements in Management Science: Applications to Online Retail, Healthcare, and Non-Profit Fundraising
… dynamic pricing problem commonly faced by online retailers. Customers arrive sequentially to the selling platform, and for each arrival the seller must make an immediate pricing decision for that customer. The seller aims to learn the demand as a function of price and customer covariates …