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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Fine particle fraction"”.
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A STUDY ON PARTICLE SURFACE ROUGHNESS AND ITS IMPACT ON TABLET AND INHALER TECHNOLOGY
… flow during tableting was studied using lactose particles of different surface roughness. Rougher particles had higher rearrangement energy requirement during tableting, decreasing the energy available for bond formation. The effects of roller compaction on materials of different deformation …
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Clarithromycin nanocrystals for high-dose inhalation
… by wet media milling. Spray-dried hollow microparticles, so called "Trojan particles", in which nanocrystals are incorporated in a matrix shell are designed for deep-lung deposition while retaining good flow and dispersion. Hydroxypropyl methylcellulose (HPMC) served as a dual-function …
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Development of dry powder Inhaler and nebulised nanoparticles formulations of chrysin for the potential treatment of asthma. Development of dry powder inhaler of chrysin and nebulised nanoemulsion combination of chrysin and budesonide; Evaluating the anti-inflammatory activity of the combination formulation of chrysin and budesonide for asthma
… and spray drying, to obtain a suitable particle size for inhalation. The highest fine particle fraction was 27% when the sonocrystallised samples were used. As the lung deposition was relatively low, budesonide was not added to the formulations. Next, liquid formulations of chrysin and …
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Controlled release in inhalation
… spray dried powders, with in vitro respirable fractions (Fine particle fraction, FPF: F < 5µm) exceeding 80% of the total dose. The second experimental chapter introduces the biocompatible polymer chitosan (mw 190 – 310 kDa) to formulations containing leucine with findings of increased FPF with …
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Development and in vivo Analysis of Inhaled Clofazimine for the Treatment of Pulmonary Tuberculosis
… drug content, hydrodynamic and aerodynamic particle size distribution, antibacterial efficacy, cytotoxicity, and solubility. Moreover, formulations were also characterized for their solid state and particle morphology. Lead formulation was dosed in BALB/c mice to analyze the amounts of …
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DRY POWDER INHALATION OF PNEUMOCOCCAL VACCINE USING POLYMERIC NANOPARTICLES AS CARRIERS
… vaccine formulation containing polymeric nanoparticles (NPs) adsorbed with PspA4Pro and formulated into nanocomposite microparticles (NCMPs) using L-leucine (L-leu) to be delivered via inhalation was developed. Poly(glycerol adipate-co-ω-pentadecalactone), PGA-co-PDL, NPs with either anionic …
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Investigating Controlled Release Pulmonary Drug Delivery Systems
… ratios and drug loadings. The hybrid particles showed promise in combining the positive attributes of each excipient, with respirable particles shown to sustain the release of CS with a fine particle fraction of 30%. Combining the two excipients was complex, with further optimisation …
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Proniosome formulations for pulmonary drug delivery
… 3.06 μm and 3.32 μm respectively. Using laser diffraction for aerosol droplet size analysis, the Pari nebuliser generated aerosols with the highest fine particle fraction (FPF) (around 80%) followed by the Aeroneb Pro nebuliser (approximately 70%) and the Omron nebuliser (around 40%). The …
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Preparation and characterization of multifunctional chitosan microparticles for lung delivery
… system containing iron oxide nanoparticles and gemcitabine as the chemotherapeutic agent. Iron oxide nanoparticles were prepared by chemical co-precipitation. The iron oxide nanoparticles were made water dispersible by adding an oleic acid-poloxamer coat to the surface of the iron …
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Development of Aerosolizable mRNA Incorporated Chitosan Nanoparticles for Efficient Lung Delivery
… within the respiratory tract. The use of nanoparticles for mRNA delivery to the lungs opens a promising way for treating a wide variety of pulmonary disorders, including genetic and infectious diseases. Chitosan-tripolyphosphate (CS-TPP) nanoparticles present promising opportunities due to …
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MicroRNA Nanocarriers for the Treatment of Chronic Obstructive Pulmonary Disease
… design, formulate and characterise polymeric nanoparticles (NPs) containing miR-146a. This was followed by spray-dying using L-leucine and mannitol to prepare dry powder nanocomposite microparticles (NCMPs) for pulmonary delivery. Anionic and cationic poly (glycerol adipate-co- …
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Creation and validation of an enhanced in vitro model of the lungs
… in terms of their aerodynamic properties and particle size, and also in vitro, ex vivo and in vivo evaluation of the efficacy and the pharmacokinetic and pharmacodynamic properties of the formulations. However, a need is felt for improved models of aerosol testing, which closely simulate the …
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Drug nanosizing using microfluidic reactors. Development, characterisation and evaluation of corticosteroids nano-sized particles for optimised drug delivery.
Over recent years the delivery of nanosized drug particles has shown potential in improving bioavailability. Drug nanosizing is achieved by ¿top-down¿ and by ¿bottom-up¿ approaches. Owing to limitations associated with the top-down techniques, such as high energy input, electrostatic effects, broad …
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Development of Afatinib lipid nanoparticles targeting non small cell lung cancer
… method. The obtained liposomes had a small particle size of less than 50 nm with a low polydispersibilty index and acceptable zeta potential. The highest Encapsulation Efficiency (EE%) of AFT reached 43.20%, 50.20%, and 52.01% for NL (Non targeting liposomes), PSL, CL, respectively at the …
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Evaluation of the Effect of Critical Process and Formulation Parameters on the Attributes of Nanoparticles Produced by Microfluidics. Design of Experiments Approach for Optimisation of Process and Formulation Parameters Affecting the Fabrication of Nanocrystals of Poorly Water-Soluble Drug Using Anti-solvent Precipitation in Microfluidic
… overcomes the challenges posed by large sized particles such as poor solubility, bioavailability, absorption, and target-specific delivery. This study focuses on nano sizing by application of microreactor technology and nanoparticles to obtain polymeric particulate with a selection of model …
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SPRAY-DRIED BIOADHESIVE FORMULATIONS FOR PULMONARY DELIVERY
… and in vitro characterisation of lipid microparticles prepared using spray-drying for drug delivery to the lung via dry powder inhalers. Bioadhesive formulations such as prochitosome or chitosome powders have been introduced to overcome the drawbacks of liposome instability and potentially …
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Relative bioavailability of terbutaline to the lungs following inhalation using different methods.
… of 4 L at inhalation flows of 10-60 L min-1. The particle size distribution was measured using an Anderson Cascade Impactor (ACI) with a mixing inlet valve to allow measurement at different flows. A steady increase in total emitted dose (TED) and the fine particle dose (FPD) was observed as the …
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Investigation to Identify the Influence of the Surface Energetics of the Dry Powder Formulations of Budesonide and Theophylline on Their Aerodynamic Dose Emission Characteristics.
Surface energetics play a key role in the delivery of a dry powder inhaler formulation into the lungs, as there must be a sufficient balance of adhesive and cohesive forces to allow optimal lung delivery. In this study, measuring the surface energies of a set of single drug and carrier (budesonide …