Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Fibrous cap"”.
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The Role of Type VIII Collagen in Fibrous Cap Formation and Progression of Atherosclerosis
… VIII collagen plays a role in formation of the fibrous cap. Deletion of type VIII collagen resulted in reduced SMC and fibrillar type I collagen content and gelatinase activity. Reduced fibrous cap thickness and increased necrotic core size were observed in plaques from these mice. The second …
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Identification of a vascular smooth muscle cell transition associated with fibrous cap formation and induced by thrombin receptor activation
… influences both plaque growth and stability. The fibrous cap, a stabilising feature of plaques, contains an abundance of VSMC-derived cells. However, the cellular transitions and regulatory mechanisms underlying fibrous cap formation remain incompletely understood. The overarching aim of my thesis …
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Carotid Atherosclerosis: Why Some Patients are Symptomatic and Others Not?
… Plaques from symptomatic patients have thinner fibrous caps overiying a iarge necrotic core, contain higher numbers of macrophages and exhibit higher teveis of apoptosis in vascuiar smooth muscie ceiis (VSMCs) than piaques from asymptomatic patients In order to test this hypothesis, carotid …
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Impact of Percutaneous Transluminal Intervention on Vascular Hypoxia and the Role of Micro-calcifications on Atherosclerotic Plaque Rupture
… fibroatheroma, a lipid-rich plaque covered by a fibrous cap. Many of these plaques are considered as vulnerable, as they grow to occlude the luminal section of the artery (chronically stenotic) or become mechanically unstable with a higher chance of rupturing (rupture-prone). On one hand, …
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Fibre Microstructure and Mechanics of Atherosclerotic Plaques
… by the progressive growth of a plaque, where a fibrous cap covers a lipid-rich core. Rupture of this fibrous cap can lead to thrombosis and a heart attack or stroke. This dissertation considered the role of plaque microstructure in the mechanics and rupture risk of atherosclerotic plaques. Fibre …
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Effect of microstructure on mechanical behaviour of arterial tissue
… CVDs are a result of atherosclerosis, in which a fibrous cap covered lipid-rich plaque is formed in the arteries. The fibrous cap can rupture, blocking the artery and limiting the flow of blood to vital organs. AAs and ADs manifest as localised dilatations of the aorta, while simultaneously …
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A Fluid Structure Interaction Model Of Intracoronary Atherosclerotic Plaque Rupture
… drop ranging from 3125 Pa/m to 9375 Pa/m, fibrous cap thickness ranging from to , lipid pool location ranging from the leading to the trailing edge of plaque, lipid pool volume relative to stenosis volume ranging from 24% to 80%, Calcium volume relative to stenosis volume ranging from 24% …
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Elastography using optical coherence tomography : development and validation of a novel technique
… characterized by an accumulation of lipid and fibrous tissue in the arterial wall. Postmortem studies have characterized rupture-prone atherosclerotic plaques by the presence of a large lipid-rich core covered by a thin fibrous cap. Studies employing finite element analysis (FEA) based on ex …
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Functions of small leucine-rich repeat proteoglycans in connective tissues
… plaques, regulating the growth of the fibrous cap and activity of smooth muscle cells. These observations validate further investigations into this field of connective tissue biology.
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Development of multimodal spectroscopy for the detection of vulnerable atherosclerotic plaques
… is shown to have the ability to detect a thin fibrous cap, necrotic core or superficial foam cells, and thrombus.
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Mitochondrial function in atherosclerosis and vascular smooth muscle cells
… including healthy media, shoulder region, fibrous cap and core and their respiration was investigated. The respiratory reserve capacity (RRC) of the shoulder region was similar to the media. However, the cap RRC was significantly reduced compared to healthy media. In contrast, the …
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Development of a Vascularized Carotid Artery Plaque Phantom for the Investigation of Novel Ultrasound-Based Technologies
… characterized by a large lipid core, a thin fibrous cap, and neovascularization – features that increase the risk of plaque rupture and thrombosis. Intraplaque neovascularization (IPN) in advanced lesions in the carotid artery can be visualized using contrast-enhanced ultrasound (CEUS) …
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Vascular smooth muscle cell heterogeneity and plasticity in models of cardiovascular disease
… both alpha Smooth muscle actin (aSma)-positive fibrous cap and Mac-3-expressing macrophage-like plaque core cells. Co-staining for phenotypic markers further identified a double-positive aSma+ Mac3+ cell population, which is specific to VSMC-derived plaque cells. In contrast, VSMC-derived cells …
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The role of image processing and artificial intelligence machine learning-based systems for unbiased evaluation of human coronary atherosclerotic plaque progression and vulnerability, and in response to pharmacotherapy
… marker for drug and device studies. For example, fibrous cap thickness (FCT) <75µm, minimum lumen area (MLA) <3.5mm2, lipid arc >180°, and presence of macrophages, calcific nodules, neovascularisation, and cholesterol crystals are associated with major adverse coronary events (MACE). Many of these …
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Three-dimensional Quantitative Magnetic Resonance Imaging of Carotid Atherosclerotic Plaque
… of atherosclerotic plaque such as a thin fibrous cap, large lipid-rich necrotic core, intraplaque haemorrhage and ulceration have shown correlations with subsequent clinical events. High resolution, multi-contrast magnetic resonance imaging (MRI) can qualitatively identify these features …
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The role of lipoproteins in vascular calcification and plaque stabilisation
… whereby smaller growths, particularly in the fibrous cap, increase likelihood of rupture and larger sheets decrease likelihood. Although lipoproteins, namely high (HDL), low (LDL), very low (VLDL) density lipoproteins and lipoprotein (a) (Lp(a)), have been previously studied in their …
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Investigation Into The Role Of Biomechanical Forces In Determining The Behaviour of Coronary Atherosclerotic Plaques
… Post-mortem studies have identified thin-cap fibroatheroma (TCFA) as the plaque subtype most prone to rupture with prospective virtual-histology intravascular ultrasound (VH-IVUS) studies linking VH-TCFA to future adverse clinical events. VH-TCFA are however common along the coronary tree …
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Classification of atherosclerotic plaque vulnerability by mechano-radiomics
… relating to plaque rupture. Locations at the fibrous cap, plaque shoulder and the bifurcation region were considered to evaluate the critical stress. The hypothesis of higher stress on the culprit side was proved to be robust to different material parameters. Evaluations of wall shear stress …