Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 839 for “"Fibrosis"”.
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Cystic Fibrosis-Related Diabetes, Periodontitis, and Quality of Life in Adults with Cystic Fibrosis
… on the oral health of individuals with cystic fibrosis (CF), even though poor oral health is a potential contributor to worsening chronic health conditions. Periodontitis, the inflammation of hard tissues that support and anchor the teeth, is a source of infection that could compromise the …
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Immune Dysfunction in Cystic Fibrosis
Cystic Fibrosis (CF) is one of the most widespread life-shortening genetic diseases. CF is often diagnosed at birth; there is no cure, and many CF patients die from chronic lung disease at a young age. Patients with CF experience declining pulmonary function related to chronic airway infection, …
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A cystic fibrosis infection monitor
… in people with the inherited disorder, cystic fibrosis (CF). These chronic infections result in a high rate of morbidity and mortality. Once established, the infections are almost impossible to eradicate. Pulmonary exacerbations, thought to be caused by P. aeruginosa, result in further damage …
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Tomosynthesis in pulmonary cystic fibrosis
… tomosynthesis might be used in pulmonary cystic fibrosis, to design and validate a tomosynthesis scoring system, and to determine the effective dose from chest tomosynthesis in children. In a prospective study starting in 2008 clinical chest radiography or computed tomography (CT) were …
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The pathogenesis of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a restrictive pulmonary disorder of unknown aetiology with a relentless disease course and a median survival of 3 years after the diagnosis. It is the most common idiopathic interstitial lung disease (ILD) with a basal and peripheral predominance associated …
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Cystic fibrosis and the gut microbiota
… in numerous disease states, including Cystic Fibrosis (CF) cohorts. This thesis investigates the gut microbiota and microbiome in CF persons and how it may be manipulated through interventions with the potential to improve respiratory symptoms in CF persons. Firstly, in order to survey the CF …
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Fibroblasts: Key Cells in Inflammation and Fibrosis
Angiotensin II (Ang II) infusion into normolipidimic mice leads to the development of aortic dissections and abdominal aortic aneurysm (AAA). IL-6 is a pro-inflammatory cytokine that is secreted by fibroblasts and macrophages in the aortic adventitia and promotes the development of aortic …
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Biochemical and immunological investigations into cystic fibrosis
… heterozygous and homozygous for the cystic fibrosis (CF) gene, two general approaches were adopted. In the first, attempts were made to produce an antiserum specific for the cystic fibrosis factor (CFF), a substance known to be present in the serum and secreted by fibroblasts of both CF …
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Role of Macrophages in Ocular Surface Fibrosis
… thus contributing to oGVHD-associated fibrosis.</p> <p>Bone marrow cells were cultured in M-CSF to obtain M0 macrophages, which were subsequently polarized into M1 and M2 phenotypes using IFN-g + LPS and IL-4, respectively.</p> <p>The macrophages were exposed to 7 Gy radiation. The …
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Tackling Mycobacterium abscessus infection in Cystic Fibrosis
… increasing worldwide, especially among Cystic Fibrosis (CF) patients. During my PhD, I studied key aspects of the biology of M. abscessus spp.; particularly, I studied host-pathogen interactions, antimicrobial resistance mechanisms, and genetic determinants of virulence. First, I performed …
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Cystic Fibrosis Transmembrane Conductance Regulator Modulator Therapies in Cystic Fibrosis: A Retrospective Evaluation of a Nationwide Specialty Pharmacy Database
<p>Background: Cystic fibrosis (CF) is a progressive, genetic disorder caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Patients with CF experience excessive mucus build up and infections leading to complications in the pancreas, lungs, and other organs. …
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Cardiac Fibrosis and Ventricular Arrhythmogenesis: Unravelling the influence of fibrosis on electrical dysfunction in the development of heart failure
… by significant structural remodelling such as fibrosis (Ma 1998; LeGrice et al. 2012). While structural remodelling is a hallmark of progression towards HF, its role in arrhythmogenesis remains an area of debate. With this in mind, the principal objectives of this study were to characterise the …
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LIVER FIBROSIS IMPAIRS HEPATOCYTE TRANSDUCTION BY AAV VECTORS
… with no or negligible hepatic damage and fibrosis. Preliminary evidence suggests that AAV-mediated gene transfer to hepatocytes may be hampered by liver fibrosis, but knowledge about AAV vector interactions with fibrotic livers is still very limited. In the present study, we investigated …
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The role of sphingosine kinases in pulmonary fibrosis
Pulmonary Fibrosis is defined by the development of excessive connective tissue as a response to injury. One of the major mechanisms of fibroblast accumulation is epithelial-mesenchymal transition (EMT) and the Transforming Growth Factor-β1 (TGF-β1) is one of the growth factors that regulate this …
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Role of Dopamine Receptor 3 in Cardiac Fibrosis
… have been removed from the market due to fibrosis and heart valve regurgitation. We hypothesized that there is an intrinsic cardiac dopaminergic system and changes to that system can lead to left ventricular (LV) remodeling and particularly, cardiac fibrosis. The first aim focused on …
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Quality of life in adults with cystic fibrosis
… and psychosocial factors observed in cystic fibrosis (CF), has the potential to severely impact on the health related quality of life (HRQoL) experienced by adults with CF. To date, FIRQoL has not been systematically assessed in adults with the disease. This is primarily for two reasons; (a) …
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