Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"Fibrosi cistica"”.
-
Valutazione dell'efficienza, efficacia e sicurezza di vettori lentivirali nel trasferimento del gene CFTR in sistemi modello di epitelio respiratorio in fibrosi cistica
… of the possible strategies for therapy of Cystic Fibrosis is based on gene therapy. Gene therapy goal is to provide a normal copy of CFTR gene to defective tissues by using different gene transfer agents. HIV-1 derived vectors allow a prolonged expression of therapeutic gene and they are able to …
-
FUNCTIONAL CHARACTERIZATION OF THE INTERACTION BETWEENP. AERUGINOSA AND DENDRITIC CELLS TRIGGERING THE DIFFERENTIATION OF PATHOGENIC TH1/17 CELLS IN CYSTIC FIBROSIS.
La fibrosi cistica (CF) è una malattia genetica caratterizzata da una risposta infiammatoria cronica ed eccessiva a infezioni polmonari persistenti, prevalentemente causate da Pseudomonas aeruginosa (Pa). Nonostante l’ambiente polmonare ostile generato dalla disfunzione del CFTR, Pa è in grado …
-
Isolation of human amniotic stem cells from term placenta and their in vitro differentation in airway epithelium to correct CF phenotype
Cystic fibrosis (CF) is a lethal autosomal recessive disorder due to mutations in the CF transmembrane conductance regulator (CFTR) gene, a cAMP-dependent chloride channel expressed on the apical side of epithelial cells. Although CF involves many organs with secretory/absorptive properties, …
-
Studio in vitro dell'espressione di varianti del gene CFTR con ruolo patofisiologico non ancora definito
The mutational screening of the CFTR gene, performed with three progressive steps (screening of the most common mutations with a commercial diagnostic kit, analysis of deletions/duplications with MLPA assay and sequencing of the coding CFTR regions) leads to a detection rate of about 94%. The …