Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Fibroblast growth factors"”.
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Function of two closely related fibroblast growth factors in early mesoderm development of <em>Drosophila melanogaster</em>
… (Ths) and Pyramus (Pyr) are the ligands for the Fibroblast-Growth-Factor (FGF)receptor Heartless (Htl), which is expressed in all mesodermal cells during gastrulation. To understand how these two FGFs orchestrate mesoderm spreading in gastrulation and mesoderm differentiation during …
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Expression and Purification of Unlabelled and Isotopically Labelled Human Fibroblast Growth Factor-1 and its Receptor Relevance in Cancer Research
<p>Studies show that fibroblast growth factors (FGFs) control variety of cellular activities such as mitosis, cell differentiation, survival and angiogenesis. The FGF family consists of 23 different heparin-binding proteins. One of the most intensively studied members is human FGF-1 (hFGF-1) …
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Innovative Purification Protocol for Heparin Binding Proteins: Relevance in Biopharmaceutical and Biomedical Applications
… classes of heparin binding protein is the fibroblast growth factors (FGFs) and its receptors (FGFRs). In this study, we report an efficient off-column purification of FGF-1 from soluble fractions and purification of the D2 domain of FGFR from insoluble inclusion bodies, using a weak …
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Understanding the Molecular Level Interactions of Cancer Inhibitor Imatinib with Human Fibroblast Growth Factor-1
<p>Fibroblast growth factors (FGFs) lack signal sequences, and are exported through endoplasmic reticulum (ER)-Golgi-independent non-classical routes. FGFs work as modulators of various cellular activities like mitosis, differentiation, survival etc. Among the FGF family, which comprises of 23 …
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Expression and Putative Functions of Fibroblast Growth Factor 10 (Fgf10) in Developing and Adult Skeletal Muscles
… and maturation are much less understood. Fibroblast growth factors (Fgfs) are potent regulators of myoblast proliferation and differentiation in vitro. However, their in vivo functions in myogenesis have yet to be fully elucidated. This study was prompted by the discovery of Fgf10 …
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Neural Stem / Progenitor Cells in the Adult Mouse Hypothalamus
… hypothalamic stem / progenitor proliferation by fibroblast growth factors. I demonstrate that FGF signalling is necessary for in vitro proliferation. Finally, my studies suggest that endogenous FGFs may regulate hypothalamic stem cell proliferation.
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The Physiology and Pharmacology of FGF21 in the Exocrine Pancreas
… with prolonged ISR activation. In the pancreas, fibroblast growth factor 21 (FGF21) is highly expressed, induced by feeding and acts in an autocrine/paracrine fashion. The pancreas also expresses the FGFR1/beta-klotho receptor complex that FGF21 binds to elicit downstream signaling. The …
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Patterning of the embryonic vertebrate Brain in Response to Fibroblast Growth Factor Signaling
… the early developmental phases of the zebrafish, Fibroblast growth factors (Fgfs) are involved in the molecular patterning of various tissues, including two regions of the brain, the forebrain and the midbrain-hindbrain region, affecting cellular processes as diverse as cell proliferation, …
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Fgf4 and Wnt5a/Pcp Signaling Promote Limb Outgrowth by Polarizing Limb Mesenchyme
… the molecular and cellular mechanisms whereby fibroblast growth factors (FGFs) mediate outgrowth of the limb. Specifically, we examined the epistatic relationship between FGF and Wnt/Planar cell polarity (PCP) signaling in establishing cell polarity as a mechanism for outgrowth. By implanting …
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Progesterone receptor targets play critical roles in maintaining pregnancy and disease prevention
… expression. BPA also stimulated expression of fibroblast growth factors (FGF), stromal derived factors that drive uterine epithelial proliferation. Increased expression of the pro-proliferative FGFs coupled with decreased expression of the anti-proliferative HAND2 led to aberrant epithelial …
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The Role of FGF Signaling in the Regulation of Adult Murine Cardiomyocyte Contractility and Pathologic Hypertrophy
… and treat these diseases more effectively. Fibroblast growth factors (FGFs) and their receptors are part of a large family of highly conserved signaling molecules that have been implicated in postnatal cardiac remodeling. FGF signaling increases following injury to the heart, and published …
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Regulation of the FGF14:Nav Interactome by a GSK-3 Centered Pathway
… β-IV-spectrin, neurofascin, and intracellular fibroblast growth factors (iFGFs, FGF11-14). Dysregulation of the sodium channel complex is associated with a panorama of psychiatric disorders in both animal models as well as human genome-wide association studies. However, the cellular signaling …
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Molecular Level Interaction of Human Fibroblast Growth Factor-1 (hFGF-1) With Phloridzin
<p>Fibroblast growth factors (FGFs) are a family of growth factors which includes twenty three proteins. FGFs work as modulators for various cellular activities like mitosis, differentiation and survival. Among the FGF family, human fibroblast growth factor-1 (hFGF-1), which is also known as acidic …
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Gene Expression in mESC Deficient in FGFR Signalling and the Identification of the Novel Gene Ened
… Among several signalling pathways and inductive factors, the fibroblast growth factors (FGFs) and their receptors (FGFRs) have been shown to be important during early embryogenesis. Previously it has been shown that ESCs expressing a mutant form of FGFR failed to form the two characteristic cell …
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Understanding the Molecular Basis for FGF15/19 and FGF21 Actions on Energy Homeostasis
… have been discovered within a subfamily of the fibroblast growth factor superfamily. The FGF15/19 subfamily is composed of atypical FGFs lacking the heparin-binding domain, which enables them to act in an endocrine fashion by diffusing away from their tissues of origin. They signal through …
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Signaling mechanisms and developmental function of fibroblast growth factor receptors in zebrafish
Fibroblast growth factor (Fgf) signaling plays multiple inductive roles during development of vertebrates (Itoh 2007). Some Fgfs, such as Fgf8, are locally secreted and signal over a long range to provide positional information in the target tissue (Scholpp and Brand 2004). Fgf ligands signal in a …
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Role of Msx homeobox genes in uterus during embryo implantation
… have identified a variety of molecules including growth factors, cytokines, transcription factors, and extracellular matrix proteins as potential regulators of this complex process. This dissertation work investigates the critical role of Msx homeobox genes in the uterus during embryo …
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Investigating fibroblast growth factor and its role in canine osteosarcoma
… molecules such as cytokines, chemokines and growth factors. Investigating these factors may identify a stimulus for a less differentiated and more aggressive neoplasia. This is even more compelling if the stimulus is a druggable target. Fibroblast growth factors (FGFs) interact with …
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FGF signaling in Xenopus laevis lens regeneration
… Finally, the sufficiency of various factors for lens regeneration was tested using an in vitro cornea culture assay. FGF1 strongly induced lens formation, and FGF8 also appeared to weakly induce lens formation, whereas FGF2 and FGF9 did not induce lens formation. In addition, insulin …
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