Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 178 for “"Fibroblast Growth Factor"”.
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The Role of Acidic Fibroblast Growth Factor and Fibroblast Growth Factor Receptor 4 In High Grade Serous Carcinoma
… for the presence of several members of the fibroblast growth factor signaling axis. In particular acidic fibroblast growth factor (<em>FGF1</em>) has been demonstrated to be one of the driving genes in mediating the observed prognostic effect of the amplicon in ovarian cancer patients. This …
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Metabolic Regulation by Fibroblast Growth Factor 21
Fibroblast growth factor 21 (FGF21) is a secreted hormone that can beneficially regulate glucose and lipid homeostasis. Through a reverse endocrinology approach, we uncovered that FGF21 expression is transcriptionally regulated by the peroxisome proliferator activated-receptor alpha (PPARa) in …
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Glycosaminoglycan-protein interactions : the fibroblast growth factor paradigm
… such as anticoagulation, angiogenesis and growth factor activation. The specificity involved in the HSGAG-protein interactions stems from the structural heterogeneity of HSGAGs, which are highly acidic biopolymers associated on the cell surface and in the extracellular matrix. It is …
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Identification of novel components in fibroblast growth factor signalling
Fibroblast growth factor receptors play many roles in development, cell proliferation and differentiation. They possess intrinsic tyrosine kinase activity which enables activation of other signalling proteins, formation of multiprotein signalling complexes and activation of downstream cascades. The …
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Investigating fibroblast growth factor and its role in canine osteosarcoma
… molecules such as cytokines, chemokines and growth factors. Investigating these factors may identify a stimulus for a less differentiated and more aggressive neoplasia. This is even more compelling if the stimulus is a druggable target. Fibroblast growth factors (FGFs) interact with …
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Signaling mechanisms and developmental function of fibroblast growth factor receptors in zebrafish
Fibroblast growth factor (Fgf) signaling plays multiple inductive roles during development of vertebrates (Itoh 2007). Some Fgfs, such as Fgf8, are locally secreted and signal over a long range to provide positional information in the target tissue (Scholpp and Brand 2004). Fgf ligands signal in a …
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The effects of fibroblast growth factor-2 om human bone marrow cells
Bibliography: leaves 163-191.
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Heparan sulfate mediated transport of basic fibroblast growth factor through extracellular matrix
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1998.
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Molecular interactions of glycosaminoglycans with fibroblast growth factor and with heparinase I
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1998.
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Molecular Level Interaction of Human Fibroblast Growth Factor-1 (hFGF-1) With Phloridzin
<p>Fibroblast growth factors (FGFs) are a family of growth factors which includes twenty three proteins. FGFs work as modulators for various cellular activities like mitosis, differentiation and survival. Among the FGF family, human fibroblast growth factor-1 (hFGF-1), which is also known as acidic …
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Patterning of the embryonic vertebrate Brain in Response to Fibroblast Growth Factor Signaling
… the early developmental phases of the zebrafish, Fibroblast growth factors (Fgfs) are involved in the molecular patterning of various tissues, including two regions of the brain, the forebrain and the midbrain-hindbrain region, affecting cellular processes as diverse as cell proliferation, …
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Nuclear Basic Fibroblast Growth Factor Regulation of Triple-Negative Breast Cancer Dormancy/Recurrence
… three years of treatment due to recurrent tumor growth. Developing ex vivo models for TN breast cancer recurrence and defining responsible molecules will be crucial to developing effective combination therapies for TN breast cancer patients. We have developed an in vitro model of TN breast cancer …
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The role of fibroblast growth factor-2 (FGF2) in vascular remodeling and adaptation
… dissertation was to test the hypothesis that fibroblast growth factor-2 (FGF2) is required during diseased-related vascular growth and remodeling in the adult organism. Given previous research, it is generally assumed that FGF2 is an important regulator of vessel growth during various …
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The role of basic fibroblast growth factor in the compensatory adrenal growth response
We have investigated the role of basic fibroblast growth factor (bFGF) in the neurally mediated compensatory adrenal growth response. Unilateral adrenalectomy resulted in a 13%, 6% and 22% increase in adrenal weight, protein and DNA content, respectively, and 33-40% increases in the rate of cell …
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