Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 661 for “"Fibroblast"”.
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Fibroblast Heterogeneity In Pancreatic Cancer Immunity
<p>Fibroblasts are a unique cell type defined by their mesenchymal phenotype and exclusion from epithelial, immune, and endothelial cell subsets. Although well studied in wound healing, cancer associated fibroblasts (CAFs) are incredibly heterogeneous, leading to contradictions as to the roles CAFs …
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MRP4-Dependent Regulation of Fibroblast Migration
… dynamics. In our study we used MRP4-expressing fibroblast cells and MRP4 knockout mice as model systems and wound healing assays as the experimental system to explore this unique and emerging concept. Here we demonstrated for the first time that mouse embryonic fibroblasts (MEFs) isolated from …
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The Role of Acidic Fibroblast Growth Factor and Fibroblast Growth Factor Receptor 4 In High Grade Serous Carcinoma
… for the presence of several members of the fibroblast growth factor signaling axis. In particular acidic fibroblast growth factor (<em>FGF1</em>) has been demonstrated to be one of the driving genes in mediating the observed prognostic effect of the amplicon in ovarian cancer patients. This …
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Metabolic Regulation by Fibroblast Growth Factor 21
Fibroblast growth factor 21 (FGF21) is a secreted hormone that can beneficially regulate glucose and lipid homeostasis. Through a reverse endocrinology approach, we uncovered that FGF21 expression is transcriptionally regulated by the peroxisome proliferator activated-receptor alpha (PPARa) in …
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Defining the Developmental Signals of the Cardiac Fibroblast
Cardiac fibroblasts play a central role as a mediator of inflammatory and fibrotic response and also secrete extracellular matrix components that provide structural support for regeneration and remodeling of the wound. Despite the importance of the cardiac fibroblast in heart disease, very little …
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Fibroblast Regional Identity in the Murine Lymphoid System
Fibroblasts are the most abundant cell type of the stroma, producing extracellular matrix components which provide mechanical strength to tissues. Recent work has shown that fibroblasts are not simply passive structural cells but active participants in the immune response. In this study fibroblast …
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Evidence of anisotropic mechanical properties of fibroblast membranes
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1988.
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Glycosaminoglycan-protein interactions : the fibroblast growth factor paradigm
… mediated by HSGAG-binding proteins such as basic fibroblast growth factor (FGF2). A number of models have been proposed to account for the mode of FGF-FGFR interactions and the role of HSGAGs in modulating FGF2 signaling. It was hypothesized that one role played by HSGAGs was to stabilize FGF2 …
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TARGETING FIBROBLAST-MATRIX INTERACTIONS TO TREAT VOCAL FOLD SCARRING
… In response to these biochemical cues, VF fibroblasts undergo a fibroblast-to-myofibroblast transition. While myofibroblasts are required for wound closure and VF repair, persistent myofibroblast activation results in the over-accumulation of a collagen-rich extracellular matrix (ECM), …
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Identification of novel components in fibroblast growth factor signalling
Fibroblast growth factor receptors play many roles in development, cell proliferation and differentiation. They possess intrinsic tyrosine kinase activity which enables activation of other signalling proteins, formation of multiprotein signalling complexes and activation of downstream cascades. The …
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The Cytotoxic Effects of Malondialdehyde on Human Lung Fibroblast Cells
… the toxic effects of MDA on the human lung fibroblasts MRC5, which have an intact p53 response, and their SV40 transformed counterpart, MRC5 SV2, which have a sequestered p53 response. Both cell lines were treated with MDA (0-1000 µM) for 24 and 48 h and subjected to a variety of analyses to …
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