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Showing 1 to 20 of 46 for “"Fibrinolysis"”.
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Fibrinolysis by bile
… chymotrypsin (mg/l), in equivalent diameters of fibrinolysis. Gradient elution by tris/NaCl from Whatman DE 32 produced four areas, or Peaks, of fibrinolytic activity of cholelysin, each with some differing characteristics against the various substrates. These complexities were not studied in …
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Studies of Coagulation and Fibrinolysis
… above the physiologic level, the balance between fibrinolysis and clotting shifts toward the latter, thus providing a biochemical rationale for the increased risk of cardiovascular disease associated with elevated level of fibrinogen.
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The role of platelets and leukocytes in endogenous fibrinolysis.
The impact of intravascular aggregation of circulating platelets and white blood cells on the plasma activity of t-PA and PAI-1 was measured. In vivo platelet and white blood cell aggregation was induced by platelet and white blood cell agonists, the effect being monitored by the Technicon …
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Role of Thrombin-Activatable Fibrinolysis Inhibitor in Breast Cancer Metastasis and Angiogenesis
… initially known for its role in attenuating fibrinolysis. TAFIa is formed through cleavage by thrombin, plasmin or, by thrombin in complex with thrombomodulin. TAFIa is a carboxypeptidase, cleaving carboxyl terminal lysine residues from plasminogen binding sites on cell surface receptors, …
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Ultrasound-enhanced Fibrinolysis Pro-fibrinolytic and Non-beneficial Effects Of Ultrasound Exposure
… are involved in ultrasound-enhanced reteplase fibrinolysis. No decreased fibrinolytic effect of reteplase depending on ultrasound exposure could be seen. In an initial study of the fibrinolytic effects induced by a combination of Sonazoid® microbubbles and ultrasound, the effects of various …
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The Role of The Plasminogen-Fibrin Interaction in The Regulation of Fibrinolysis
Fibrinolysis refers to the proteolytic mechanism whereby the body dissoloves intravascular deposits of fibrin, a process important in maintaining the patency of the circulatory system. The major components of the fibrinolytic system, plasminogen and plasminogen activator, are known to co-exist in …
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Regulation of the Gene Encoding Thrombin-Activable Fibrinolysis Inhibitor in Non-Hepatic Cells
Thrombin-activable fibrinolysis inhibitor (TAFI) is a carboxypeptidase B-like pro-enzyme that, once activated, attenuates fibrinolysis. TAFIa also possesses anti-inflammatory properties. Although liver is the main source of plasma TAFI, platelet-derived TAFI has also been reported. An alternatively …
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Angiopoietin-2 and platelet-derived growth-BB factor cooperatively affect peripheral blood monocyte fibrinolysis
Includes bibliographical references.
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The distribution of plasminogen activator in the male genital tract
… of plasmin is the digestion of fibrin, i.e. fibrinolysis. Many tissues, including the prostate (Rasmussen and Albrechtsen, 1960a), contain substances which can activate plasminogen, and thus initiate fibrinolysis, and it has been assumed that both the excessive fibrinolysis seen in the blood …
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Synthesis and structure activity relationship of novel small molecules as inhibitors of plasminogen activator inhibitor-1
… family. PAI-1 is involved in the regulation of fibrinolysis, which is the breakdown of blood clots. PAI-1 inhibits serine proteases tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), which are key factors in fibrinolysis. Excess levels of PAI-1 have also been …
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The impact of thromboelastography on patients with penetrating abdominal trauma requiring intensive care
… 12% hypercoagulable and 4% mixed parameters. Fibrinolysis profiles were: 48% normal, 44% fibrinolysis shutdown and 8% hyperfibrinolysis. Mortality rate was 5% at 24 hours and 26% at 30 days, with no difference between the two groups. High grade complication rates, days on a ventilator and …
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On the induction of inflammatory reactions by Streptococcus pyogenes
… as a superantigen. Thrombin activatable fibrinolysis inhibitor (TAFI) is a human procarboxypeptidase circulating in plasma. When activated, TAFI inhibits fibrinolysis and modulates the immune system by cleaving inflammatory mediators such as C5a, fibrinopeptides and bradykinin. Here we …
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A study of platelets and the endothelium in idiopathic pulmonary fibrosis
… of plasma markers of endothelial activation and fibrinolysis in IPF.We demonstrate that IPF patients exhibit increased platelet reactivity and that this can be reproduced in control platelets following incubation in IPF plasma suggesting that a plasma factor is responsible for this phenomenon. In …
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Progress toward a structure-function relationship for novel, small-molecule inhibitors of plasminogen activator inhibitor-1
… plasminogen activator (uPA), and hence, fibrinolysis. This inhibition leads to decreased plasminogen to plasmin conversion, which results in deleterious effects on the organism, such as blood clots. Elevated levels of PAI-1 are implicated in a variety of diseases and conditions. We have …
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A Quantitative Investigation of Selected Reactions in the Fibrinolytic Cascade
Previous work has shown that thrombin activatable fibrinolysis inhibitor (TAFI) was unable to prolong lysis of purified clots in the presence of Lys-plasminogen (Lys-Pg), indicating a possible mechanism for fibrinolysis to circumvent prolongation mediated by activated TAFI (TAFIa). Therefore, the …
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Bioenergetic and functional impacts of glucose, fructose and insulin in endothelial cells:: implications for cardiovascular disease in diabetes
… mediators of vessel tone (NO, endothelin-1) and fibrinolysis (tissue plasminogen activator, plasminogen activator inhibitor-1). These effects were not reversed after acute exposure to NG. Addition of fructose increased markers of metabolic activity, but reduced NO generation. The effect of …
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Generation of novel small molecules as inhibitors of plasminogen activator inhibitor-1
… (uPA), and thus is a primary regulator of fibrinolysis, the process that results in breakdown of blood clots. PAI-1 also exhibits effects on various human ailments including atherosclerosis, stroke and diabetes, with which high levels of PAI-1 have been associated. The goal of this research …
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Design, synthesis and evaluation of small molecules as inhibitors of plasminogen activator inhibitor-1
… plasminogen activator (tPA), which regulates fibrinolysis as well as the development of different pathological diseases like obesity, metabolic syndrome, tumor invasion and metastasis, and coronary heart disease. Currently, there is no Food and Drug Administration approval for inactivating …
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Gene transfer of keratinocytes with a human Factor XIII - plasmid construct
… clot achieves an improved stability and a high fibrinolysis resistance. This provides a provisional matrix for the cell migration and attachment, thereby contributes to wound healing. Gene transfer offers an attractive method for localised and transient active delivery of factors to healing …
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