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Showing 1 to 20 of 152 for “"Fibrin"”.
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Metals and the conformation of fibrin
The carboxy terminal of the γ-chain of human fibrinogen contains at least three biologically. important functional domains: (i) the fibrinogen γ-chain polymerisation centre, (ii) the platelet receptor domain and (iii) the site for staphyloccocal clumping. The nature of the site specificity of these …
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Single Fibrin Fiber Mechanical Properties and Lysis
Fibrinogen, one of the most abundant proteins in blood plasma, plays a central role in hemostasis and thrombotic disease. In the final step of the coagulation cascade, thrombin proteolytically converts fibrinogen to fibrin, which then forms a mesh of fibrin fibers. This mesh is the major structural …
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The D-domain of fibrin : structural and functional studies
The D-domain of fibrin (ogen) was separated from the parent molecule by plasmin digestion in the presence of calcium and isolated by means of DEAE-anion exchange chromatography followed by gel-filtration in buffer containing 4 M urea. Fluorescent-D-dimer (f-D-dimer) was isolated from a plasmic …
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The Mechanical Properties of Individual Electrospun Fibers and Fibrin Fibers
… cartilage and blood vessels, to name a few. Fibrinogen, a plasma protein, is converted into fibrin fibers which form the mechanical and structural support for blood clots. Biomimetic nanofibers can be synthesized outside of the body through the process of electrospinning. The mechanical …
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EVALUATING THE USE OF TURBIDIMETRY FOR STUDYING FIBRIN STRUCTURAL PROPERTIES
A fibrin fiber mesh forms the structural backbone of blood clots. Many pathological conditions result in fibrin gels with altered structural properties, so there is interest in developing rapid and accurate ways to characterize fibrin features. One method of determining the diameter and mass-length …
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Autologous Fibrinogen Purification and Concentration For Use in Fibrin Sealant
<p>Fibrinogen concentrates are used widely as a sealant during and after surgery to reduce blood loss. Commercially available fibrin sealants are made from pooled human blood, which carries the risk of blood-borne diseases, and are expensive. These concerns have brought to focus the need for …
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Fibrin targeting microbubbles for the detection of nascent surgical adhesions
… adhesions. This thesis examines the use of fibrin-targeting microbubbles as an ultrasound contrast agent to diagnose peritoneal adhesions. Fibrin targeting is achieved by integrating a CREKA (Cys-Arg-Glu-Lys-Ala) peptide into the microbubble shell. The properties of targeted and non-targeted …
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The effectiveness of fibrin sealants in head and neck surgery
The utilisation of fibrin sealants as adjuncts in haemostasis during head and neck surgery has garnered increasing attention, yet their clinical efficacy remains a subject of debate. This thesis evaluates the effectiveness of fibrin sealants in patients undergoing head and neck surgery through a …
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Characterisation of fibrinogen and fibrin proteolysis by the neutrophil membrane
… membrane associated protease which degrades fibrinogen, fibrin and C-reactive protein (CRP) during incubation of these ligands with phorbol 12-myristate 13-acetate (PMA, 5-10 ng/ml) stimulated neutrophils. This proteolysis is predominantly an extracellular event which occurs through a ligand …
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Measuring the Microscale Mechanical Properties of Fibrin Fibers and Cancer Cells
… the macroscale behavior of biological systems. Fibrinogen, one of the most abundant proteins in blood, is converted into fibrin fibers that perform the essential mechanical task of stemming the flow of blood. Fibrinogen fibers can be fabricated by a technique called electrospinning. We studied …
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Development of a fibrin-based muscle construct for soft palate muscle regeneration
Contains fulltext : 244739.pdf (Publisher’s version ) (Open Access)
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The Effects of Smooth Muscle Cells on Engineered Microvasculatures in Fibrin Hydrogels
… angiogenesis during microvascular development in fibrin hydrogels using 3-dimensional co-culture models of angiogenesis. These studies are meant to model angiogenic processes in the wall of a fibrin-based tissue engineered blood vessel containing ECs and SMCs. Our results demonstrate that SMCs …
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The evaluation of fibrin tissue adhesive for skin closure following eyelid surgery
The use of fibrin tissue adhesives in clinical practice has grown over the past 10 years, and there has been increased use of adhesives in different surgical subspecialties. Conventional suture closure of periorbital tissues is effective however may result in complications, which has led to the …
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Pathogenesis of post surgical adhesions and prevention using a novel fibrin sealant
… characterised by the inflammatory response and fibrin deposition and maturation; and (ii) PSA remodelling occurring from 16 hours onwards and characterised by tissue repair, collagen deposition and maturation and chemical mediation by TGF-P. Treatment with VivostatTM System Derived (novel) …
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The Role of The Plasminogen-Fibrin Interaction in The Regulation of Fibrinolysis
Fibrinolysis refers to the proteolytic mechanism whereby the body dissoloves intravascular deposits of fibrin, a process important in maintaining the patency of the circulatory system. The major components of the fibrinolytic system, plasminogen and plasminogen activator, are known to co-exist in …
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Computational model of intraluminal thrombus growth in abdominal aortic aneurysms with fibrin generation
… growth model, which incorporates conversion of fibrinogen to fibrin, variation between clot core and shell, and mechanical lysis. The model generates ILTs with morphologies visually similar to those typically found in the body, however more work is required to refine and validate the mode.
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Fibrin Formation and Dissolution in the Progression of Amyloid-Beta Pathology in Alzheimer's Disease
… neurovascular damage in AD mice, and showed that fibrin deposition potentiates these processes. We then found that Aβ binds to fibrinogen and alters fibrin clot formation. Clots formed in the presence of Aβ have an abnormal structure and are resistant to degradation by fibrinolytic enzymes. We …
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Rapid formation of cell-mediated microvascular networks in collagen, fibrin, and puramatrix provisional matrices
… after 7 days in vivo, including collagen I, fibrin, and PuraMatrix, as well as Matrigel. Vessel networks, lined by ECFCs and overlaid by alpha αSMA+ perivascular cells, formed at 50 vessels/mm^2 in collagen and fibrin ECMs, 100 vessels/mm^2 in Matrigel, and 150 vessels/mm^2 in PuraMatrix. …
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The Effect of Acute Exercise on Coagulation Factors and the Mechanical Properties of Fibrin Fibers
… of acute exercise on coagulation factors and fibrin fiber properties in both younger, healthy subjects and older, subjects with cardiovascular disease (CVD). In addition, it was of interest to examine relationships between coagulation factors and fibrin fiber properties during acute exercise. …
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