Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Fibrillogenesis"”.
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Improving Collagen-Mimetic Fibrils to Study Fibrillogenesis and Effects of Disease-Causing Mutations on Fibrillogenesis
… corroborating the unit-staggered model of fibrillogenesis. The findings additionally elucidate the quintessential, collaborative roles of both the nucleation domain and N-terminal Cystine knot towards its triple helical folding.</p> <p>Secondly, I examined the effects of a disease-causing …
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Dense Collagen Materials and the Modulation of Fibrillogenesis for Tissue Engineering
… thin sheets that serve as a platform for fibrillogenesis-modulation studies. Incorporating ionic compounds, macromolecular crowders and other biomolecules during compaction tunes fibril diameter, interfibrillar spacing and stiffness across the 5-15 kPa window characteristic of basement …
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An investigation of DNA sequence variants in genes that regulate collagen fibrillogenesis and predisposition to musculoskeletal soft tissue injuries
The aim of this dissertation was to use a case-control genetic study to investigate the association of polymorphisms within the COL5A1, MIR608, COL11A1 and COL11A2, genes with AT and/or ACL injuries in Caucasian populations. These aims were explored in three studies: i) Determine whether the COL5A1 …
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Proteoglycan genes and anterior cruciate ligament injury susceptibility
Genetic variants within genes involved in fibrillogenesis, including a polymorphism in the COL5A1 gene, have previously been associated with anterior cruciate ligament (ACL) injury susceptibility, specifically in females. Proteoglycans have also been implicated in having important functions in …
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Reconstituted collagen fibres for tissue engineering applications
… collagen molecules spontaneously form fibrils (fibrillogenesis) with the characteristic D-periodic banding similar to native fibrils. Recently, reconstituted collagen fibres have been of interest. Due to their unique advantageous properties, such as high surface area, softness, absorbency and …
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Identification and charaeterization of IAPP-derived inhibitors of cytotoxic self-assembly and amyloidogenesis of islet amyloid polypeptide (IAPP) and beta-amyloid peptide (A beta)
… and to suppress IAPP cytotoxic self-assembly and fibrillogenesis. The potencies of the effects of the different IAPP analogues differ significantly, consistent with a conformational specificity of the IAPP-analogue interaction causing their inhibitory effects. Most importantly, it is also shown …
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Relationships Between Decorin and Biglycan, Structure and Tendon Mechanics Using Mutant Mouse Models
… fibrils, association with water and role in fibrillogenesis suggest that SLRPs may play an important role in tendon mechanics. Some studies have assessed the role of SLRPs in the mechanical response of tendon, but the relationships between sophisticated mechanics, assembly of collagen and …
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Impact loading and functional tissue engineering of articular cartilage
… The known ability of decorin to control collagen fibrillogenesis suggests a putative mechanism for C-ABC's effects. Diseased articular cartilage heals poorly. For patients, the last resort is total joint replacement, though its associated morbidity and the limited lifespan of its results drive the …
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Mass spectrometry studies of immunoglobulins
… chains. All these may play critical roles in the fibrillogenesis and/or the disease pathogenesis. Experimental evidence supports the hypothesis that the proteolytic processing of amyloidogenic LCs occurs after deposition in the organ. Characterization of a plant-derived HSV8 mAb was accomplished …
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Incorporation of Cα,α-Disubstituted Amino Acids into Model Peptide Systems: Conformational Analysis and Possible Applications as Therapeutic Agents
… concentrations, both peptides completely stop Aâ fibrillogenesis. Equimolar mixtures of AMY-1 and Aβ form only globular aggregates as imaged by scanning force microscopy and transmission electron microscopy. These samples show no signs of protofibrillic or fibrillic material even after prolonged …
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Diphenylalanine self-assembly- kinetics, thermodynamics and its relevance to amyloidogenesis
… with, and differences from, the process of fibrillogenesis in polypeptides are explored in detail. The solubility of diphenylalanine in a range of organic solvents and the role of cosolvents in the kinetics of structural assembly were systematically investigated. We find that not only the …
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Elucidating protein stabilization with fluorescence techniques
… with a range of fluorescence techniques.;For the fibrillogenesis model, time-resolved emission spectra (TRES) measurements revealed two fluorescent species occurring around 33,000 and 31,500 cm-1 at 0.33 hours after preparation. After this time, the second component decreases to 30,500 cm-1and …
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Design of Collagen-Mimetic Peptides
… known as the <em>D-periodicity</em>.</p> <p>The fibrillogenesis of collagen in tissues is a complex process involving other macromolecules; the fibril formation itself, however, is a self-assembly process proceeding from the self-association of the triple helix. While many of the structural …
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Development of Collagen Mimetic Mini-Fibrils with Tunable Collagenase Susceptibility
… D-period-like axially repeating structures. The fibrillogenesis of the minifibrils showed similar dependence on the temperature, the ionic strength, and the pH to those of native collagen fibrils, indicating the mini-fibrils are stabilized by similar molecular interaction as those in native …
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Spontaneous Unfolding and Refolding of FNIII Domains Assayed by Thiol Exchange
… structure: the fibrillar FN matrix. FN fibrillogenesis is a cell‐‑mediated process, which is initiated when FN binds to integrins on the cell surface. The FN matrix plays an important role in cell migration, proliferation, signaling & adhesion. Despite decades of research, the FN matrix …
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PATHOLOGY OF THE UROGENITAL TRACT IN DOMESTIC ANIMALS
… protein, and its main functions are induction of fibrillogenesis, fibroblastic cell proliferation and migration, enhancing regeneration in normal tissue, and promoting metastasis in case of neoplasia. POSTN has already been studied in humans in several normal tissues, inflammatory processes, and …