Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 140 for “"Fibrillar"”.
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Aligned Fibrillar Collagen Matrices for Tissue Engineering
The desire for repair of tissue defects and injury is the major need prompting research into tissue engineering. Engineering of anisotropic tissues requires production of ordered substrates that orient cells preferentially and support cell viability and differentiation. Towards this goal, this …
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Macromolecular design for modulation of amyloid fibrillar assembly
… of polymer-peptide conjugates which redirect Aβ fibrillar assembly by stabilizing Aβ oligomers into structurally well-defined discrete nanostructures. The modulatory effect was achieved by taking advantages of nucleation-dependent mechanism of Aβ aggregation. We investigated the influence of …
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Biomechanics of the fibrillar adhesive system in insects
… have not been characterised for any natural fibrillar adhesive system, and many fundamental aspects are still not understood. The aim of this thesis was therefore to investigate the fibrillar adhesive system of leaf beetles as a model. To investigate the functional implications of hairy pad …
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A study of active sites on fibrillar alumina catalysts
… differed by a factor of 1 between the two fibrillar catalysts, the activity/site was about the same for the two materials. The sites were thus assumed to be the same. Butene isomerization had to be divided into two types of reactions, one involving double-bond migration (1-butene to …
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Computational Discovery of Bacterial Fibrillar Adhesins and Adhesive Domains
Fibrillar adhesins are filamentous bacterial surface proteins, which can play a key role in host-pathogen interactions. They have a characteristic protein architecture with repeating domains, called stalk domains, folding into a rod-like stalk structure. An adhesive domain is positioned at the tip …
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Controllable Adhesion In A Bio-Inspired Film-Terminated Fibrillar Surface
… adhesive that consists of a film-terminated fibrillar layer atop a substrate. We use a dynamic rod model and stability analysis to define and analyze the buckling of a fibril subjected to a prescribed shear displacement and a constant normal compressive force. Following this analysis, we …
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Novel fibrillar carbon nanotube heat transfer gels with enhanced thermal conductivities
Lubricants and cooling agents such as oil, ethylene glycol, and water are often used as traditional heat transfer fluids (HTFs) in engines, radiators, heat pumps, and other equipment which require cooling and/or energy maintenance. The United States of America (USA) spends over $80 billion on …
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Immunocytochemical studies of fungal cell surface molecules and the vicia faba-Botrytis interaction
… Pathology 41, 472-482). All three MAbs bound to fibrillar matrices associated with conidia, germ-tubes and hyphae of B. cinerea and B. fabae grown on agar, glass slides (conidia inoculated in aqueous glucose) and V. faba leaves. These matrices provided firm attachment of sporelings to glass and …
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COMPARATIVE ULTRASTRUCTURE OF APICAL CELLS AND DERIVATIVES IN BRYOPHYTES, WITH SPECIAL REFERENCE TO PLASMODESMATA
… the studied taxa is comprised of two layers. A fibrillar layer, which is the outer wall layer, contains compacted cellulosic fibrils, and represents the two adjacent primary walls and middle lamella, the latter of which is rarely discernible. An electron-lucent inner wall layer abuts the plasma …
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Cd44-Mediated Collagen Remodeling Drives Wound Resolution And Pancreatic Tumorigenesis
… aberrant accumulation of ECM components, such as fibrillar collagen or hyaluronic acid (HA), contributes to exacerbated scar formation and promotes tumorigenesis. Thus, defining underlying mechanisms governing these processes is vital to understanding disease progression. CD44 is a transmembrane …
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Investigating the Molecular Mechanisms of SNED1 Fiber Assembly in the Extracellular Matrix
… work from our lab has shown that SNED1 is a fibrillar protein participating in the formation of the ECM scaffold, however, the mechanisms leading to SNED1 assembly in the ECM remain unknown. Studies of other fibrillar ECM proteins have shown that they must establish interactions with other …
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Improving the delivery and efficacy of molecular medicine via extracellular matrix modulation : insights from intravital microscopy
… interstitium. We found that the presence of fibrillar collagen correlated with hindered diffusion in vivo, and also in vitro, in collagen gels prepared to mimic tumor extracellular matrix. Modification of the tumor collagen matrix directly with purified bacterial collagenase, or indirectly …
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Discovering non-equilibrium mechanisms that regulatestructure and function of biomolecular condensates usingphase-field modeling
… by lncRNAs. The final project focuses on the fibrillar center of the nucleolus, an important condensate that is involved in ribosome biogenesis. Using a phase-field model that explicitly accounts for rRNA-protein interactions in the nucleolus and the non-equilibrium reaction of rRNA …
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The nanostructure and degradation of C-S-H in Portland and blended cements
… homogeneous and that of outer product C-S-H was fibrillar in the water activated systems and foil-like with alkali activation. Fly ash replacement did not change the morphology of lp and Op C-S-H. Small fully hydrated cement and PFA particles were filled with a less dense lp C-S-H with morphology …
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Proteomics and dynamics of the human nucleolus
… into different domains, namely, the fibrillar centre, the dense fibrillar components and the granular components and these structures are disassembled and reassembled during mitosis in human cells. In order to understand the intricate mechanism behind these mitotic dynamics, I have …
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Solid-state NMR studies of α-synuclein fibril structure
… α-synuclein (α- syn), adopts an amyloidogenic fibrillar form in Lewy bodies. In recent years research has slowly started to unravel clear pathological links between this fibrillar protein and PD disease progression. While great progress is being made, it has become evident that the structures …
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Improving the delivery and efficacy of a cancer therapeutic via extracellular matrix modification
… significantly. In vivo multiphoton imaging of fibrillar collagen type I and injected HSV vectors largely supported the model predictions. Injected viral particles could not penetrate dense networks of fibrillar collagen. Both the initial distribution and subsequent propagation of these …
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The Role of Type VIII Collagen in Fibrous Cap Formation and Progression of Atherosclerosis
… type VIII collagen resulted in reduced SMC and fibrillar type I collagen content and gelatinase activity. Reduced fibrous cap thickness and increased necrotic core size were observed in plaques from these mice. The second study shows that the advanced plaques from mice deficient in type VIII …
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Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-Mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma
An extracellular matrix (ECM) rich in fibrillar collagens is a principal component of pancreatic ductal adenocarcinoma (PDA). The ECM provides structural support for the tumor and facilitates tumor cell survival and chemoresistance by activating cell surface receptors on tumor cells. Fibrillar …
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Protective effects of s-propargylcysteine (SPRC) on in vitro neuronal damage induced by Amyloid-Beta (25-35)
… of electrons in free radicals. Oligomeric or fibrillar A?25-35 were added to the C6 glioma cell line and the cell viabilities were compromised. The decline in cell viability was more obvious when treated with fibrillar A?25-35, which acted on exacerbating oxidative stress by increasing H2O2 …
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