Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Fibril-forming"”.
-
Investigating the self-assembly and molecular chaperone ability of casein proteins and polyproline
… is their propensity to assemble into amyloid fibrils, which are associated with many age-related diseases. Based on the stability of their predicted 'steric zipper' structures, which form the backbone of amyloid fibrils, caseins from all species contain amyloidogenic sequences. Such sequences …
-
Investigating the self-assembly and molecular chaperone ability of casein proteins and polyproline
… is their propensity to assemble into amyloid fibrils, which are associated with many age-related diseases. Based on the stability of their predicted 'steric zipper' structures, which form the backbone of amyloid fibrils, caseins from all species contain amyloidogenic sequences. Such sequences …
-
Modeling of Therapeutic Drugs, Polymers, and Self-Assembling Peptides
… of encapsulating charged viral residues and performing other inhibitory activities. B) First, we developed methods capable of designing small therapeutic peptides. These methods were used to design peptides for proteins involved in immune evasion by tumor cells. Second, we explored …
-
The Role of Force-Sensitive Interactions in Amyloid Assembly by Fungal Adhesins
… adhesins also help maintain biofilm integrity by forming fibrous protein aggregates that are linked together by non-covalent bonds between a hydrophobic segment of their sequence, termed the amyloid-forming region (AFR). At the core of these adhesin aggregates are parallel or anti-parallel β-sheet …
-
Decoding the Sequence-Dependent Properties of Intrinsically Disordered Proteins
… techniques to determine a membrane-assisted fibril forming pathway for the IDP α-synuclein, which gives us insight to Parkinson’s disease specific fibril formation.
-
Advances in oxygen-17 NMR for biological structure determination
… the structures of biological systems, such as, fibril-forming peptides and proteins, membrane proteins, and viruses, by solid-state nuclear magnetic resonance (NMR) spectroscopy has materialized as an important field due to the high-resolution details that the technique provides. While …
-
Experimental and Computational Analysis of the Synucleins
… we investigated methods of destroying protein fibrils from α-synuclein. We report that low temperature plasma can disrupt synuclein fibrils and proposed that neuronal macrophages can eliminate the resulting structures via phagocytosis. We also conducted inhibition studies to investigate the …
-
Improving Collagen-Mimetic Fibrils to Study Fibrillogenesis and Effects of Disease-Causing Mutations on Fibrillogenesis
… undiscovered regarding its function at the fibril level due to the lack of an effective collagen model system. Using tandemly repeating “sequence units” that contain sequences from native collagen, our lab has previously developed fibril-forming collagen-mimetic peptides (FCMPs), which …
-
Molecular Dynamics and Mechanical Behavior of Collagen Type I and its Lysine/Hydroxylysine-derived Crosslinks
… type I molecules, their organization into fibrils, and the presence of inter-molecular, covalent, enzymatic crosslinks. There are several different types of these crosslinks; their composition is tissue-specific and dependent upon factors such as age and health. Furthermore, these enzymatic …