Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Fgfr2"”.
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The Roles of EGFR and FGFR2 in Cell Shape Maintenance of Human Lung Tip Progenitor Epithelial Cells
The Roles of EGFR and FGFR2 in Cell Shape Maintenance of Human Lung Tip Progenitor Epithelial Cells Recent work in the developing human lung has identified distal tip epithelial progenitors that are SOX9+SOX2+ and give rise to all lung epithelial cell types (Danopoulos et al., 2019b; Miller et al., …
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Competition Between Grb2 and Plcγ1 For Binding to Fgfr2 Regulates Phospholipase and Pten Activity, Leading to Cell Invasion and Proliferation
… with the SH3 domain of Grb2 for binding to FGFR2 in a concentration-dependent manner. Consequently, reduction of cellular concentrations of Grb2 lead to receptor-dependent recruitment of unphosphorylated Plcγ1. Bringing of the phospholipase to the membrane in this way upregulates its …
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Combination of CT-based Radiomics Features and Clinical Data for Predicting Tumor Genetic Profile in patients with Intrahepatic Cholangiocarcinoma
… scans and molecular profiling (NGS or FISH for FGFR2 fusion/rearrangement). Genetic analysis was conducted on surgical specimens (for resectable patients) or biopsies (for unresectable ones). Radiomic features were extracted using LifeX software. Multivariate models were developed to predict …
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Signaling mechanisms and developmental function of fibroblast growth factor receptors in zebrafish
… morpholino knockdown studies we also show that Fgfr2 is required for growth and skeletal development in zebrafish, whereas Fgfr4 is required for pectoral fin specification and growth.
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An immunoproteomic approach to identifying cancer-associated autoantibody biomarkers
… for melanoma included CEACAM 1, DPPA2, FGFR2, ITGB1, MAGEA10, NANOG, PIM1, SPANXB1, THEG and XAGE1B. Using these biomarker candidates, distinct clusters of HCs and melanoma patients were identified in both unsupervised hierarchical clustering and PCA analysis. Combinatorial ROC analysis …
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FGF signaling in Xenopus laevis lens regeneration
… lens regeneration. Three receptor mRNAs (FGFR1, FGFR2, and FGFR3) were found to be expressed in the cornea. Second, the necessity of FGFR signaling was investigated in vitro using a small molecule inhibitor (SU5402) and dominant negative FGFR1. Both experiments demonstrated that lens regeneration …
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The Influence of Preovulatory Estradiol on Uterine Transcriptomics and Proteomics Around Maternal Recognition of Pregnancy in Beef Cattle
… relative abundance of IFNT, PTGS2, TM4SF1, C3, FGFR2, and GAPDH. Total cellular RNA was extracted from endometrium for RNA sequencing. ULF pools (n=28) for the following groups: highE2/noconceptus, highE2/conceptus, lowE2/noconceptus, and lowE2/conceptus were analyzed using a 2D LC-MS/MS based …
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The role of genetic factors in breast cancer aetiology
… studies such as the association of SNPs in FGFR2,<br/>TNRC9 and ATM with oestrogen receptor status and identified novel associations of SNPs in the<br/>oestrogen receptor gene and matrix metalloproteinase-9 gene (MMP-9) with grade and presence<br/>of distant metastasis …
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Modulation of bovine preimplantation embryonic development and pregnancy by FGF2, LIF, and IGF1
… development; 5) characterize the necessity for FGFR2, LIFR, and IGF1R for FLI modulation of the developing embryo. Overall, this work illustrated the benefit of FLI supplementation through improved embryo development, cell membrane integrity, and cell survival after cryopreservation. …
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Molecular Epidemiology of Breast Cancer
… of SNPs from the two, highly replicated, loci FGFR2 and TOX3 could add information to screening of high risk families. Possible interactions between common genetic variants and established environmental or phenotypic risk factors for breast cancer were examined in two different studies …
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Next Generation Sequencing Reveals Gene Expression Patterns in the Zebrafish Inner Ear Following Growth Hormone Injection
… (e.g., POMC, SLC6A12, TMEM27, HNF4A, CDH17 and FGFR2) that showed up-regulation in GH-injected condition showed down-regulation in antagonist-injected condition. These results strongly suggest that injection of exogenous GH potentially has a protective role in the zebrafish inner ear following …
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Reiterative FGF signaling determines the identity and morphology of the lacrimal gland
… signal of Fgf10, which binds to epithelial Fgfr2b and co-receptor heparan sulphate proteoglycans, to promote budding and branching morphogenesis of the lacrimal gland. However, the mechanism by which Fgf10 expression is regulated within the neural crest and the direct downstream targets of …
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Breast Cancer Risk - Environmental and Genetic Effects on Cancer Development, Progression and Survival
… PTEN; and low penetrance mutations including FGFR2, CASP8 and ESR1. Additionally environmental factors influence risk, including reproductive factors, alcohol consumption, smoking and social deprivation. Of the factors identified in this literature review there was evidence that there may be …
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An Integrated Bioinformatics Approach for the Identification of Melanoma-Associated Biomarker Genes. A Ranking and Stratification Approach as a New Meta-Analysis Methodology for the Detection of Robust Gene Biomarker Signatures of Cancers.
… signature for melanoma was defined (i.e., EGFR, FGFR2, FGFR3, IL8, PTPRF, TNC, CXCL13, COL11A1, CHP2, SHC4, PPP2R2C, and WNT4). Of these, CXCL13, COL11A1, PTPRF and SHC4 are components of the MAPK pathway and were validated by immunocyto- and immunohisto-chemistry. These proteins were found to be …
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Manipulating Embryonic Development and Endometrial Function in Ruminants
… exposure, fibroblast growth factor receptor 2 (FGFR2) in a sex*obesity interaction, and peroxisome proliferator-activated receptor gamma (PPARG) and prostaglandin-endoperoxide synthase 2 (PTGS2) in a sex-specific manner. Collectively these results identify the preimplantation period as a …
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TRANSLATIONAL RESEARCH TARGETING BILIARY TRACT CANCER
… one is Kras-G12D/sgPten/NICD1 and another is FGFR2-BICC1/sgTP53/NICD1. Based on these mice models, intratumor heterogeneity and diverse drug responses will be explored. To improve the ratio of well differentiated CCA, we will use bile duct ligation technique instead of HTVI to make sure that …
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IDENTIFICATION OF NCAM1 AS A NOVEL PROGNOSTIC PROSTATE CANCER STEM CELL BIOMARKER
… high-resolution studies, we uncovered an NCAM1-FGFR2-FGF18 molecular circuitry and an NCAM1-DNER-Notch1 molecular circuitry that mediate resistance to ADT-induced senescence. Thus, targeting these pathways with FGFR or Notch pathway inhibitors could represent a promising strategy to eradicate …
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Investigating the role of CYP26 and retinoic acid signaling regulation in vertebrate cornea and lens regeneration
… can attenuate the expression of the eye markers fgfr2 and pax6 in the cornea, and CYP26 may prevent this attenuation during regeneration. Lastly, we looked at whether CYP26 was involved in early, late, or all stages of lens regeneration by varying the timepoints at which compounds were added to …
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The genetics of non-syndromic hearing impairment in South Africa
… CDH23(c.T1585C, c.G8230A), FGFR2(c.1297+10G>C), MYO7A(c.6255delC). The pathogenic variants presented 8 autosomal dominant alleles and 12 autosomal recessive alleles Five families presented with pathogenic or likely pathogenic variations associated with Usher Syndrome and the …
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