Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Fgfr1"”.
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Relevance of Fgfr1 and Its Isoforms In Prostate Cancer Bone Metastases
… in prostate cancer (PCa) progression. Various FGFR1 isoforms have been described and we demonstrate here that the well-characterized FGFR1 a and b isoforms are correlated with the expression of different genes and pathways in human PCa. Direct injection of PC3 PCa cells overexpressing FGFR1 …
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Molecular and functional studies of ABL1 and FGFR1 fusion oncogenes in myeloproliferative neoplasms
The tyrosine kinase encoding genes ABL1 and FGFR1 are involved in fusion genes underlying the myeloproliferative neoplasms chronic myeloid leukemia (CML) and the 8p11-myeloproliferative syndrome (EMS). CML and EMS are both myeloproliferative disorders with an initiating, relatively indolent, …
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Identification of novel components in fibroblast growth factor signalling
… The goal of this project was to identify novel FGFR1 interacting proteins. The strategy employed for mapping novel partners on the basis of peptide-protein interaction was peptide pull-down. Using synthetic pairs of phosphorylated and unphosphorylated peptides, pull down experiments were …
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A Systems Level Analysis of the Transcription Factor FoxN2/3 and FGF Signal Transduction in Sea Urchin Larval Skeleton Development and Body Axis Formation
… this thesis, two genes, FoxN2/3, a TF and FGFR1, a component of the FGF signaling pathway are investigated. FoxN2/3 and FGFR1 have different mechanisms that function in sea urchin development; FoxN2/3 regulates gene expression and FGFR1 changes phosphorylation of target proteins. However, …
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FGF signaling in Xenopus laevis lens regeneration
… lens regeneration. Three receptor mRNAs (FGFR1, FGFR2, and FGFR3) were found to be expressed in the cornea. Second, the necessity of FGFR signaling was investigated in vitro using a small molecule inhibitor (SU5402) and dominant negative FGFR1. Both experiments demonstrated that lens …
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The Physiology and Pharmacology of FGF21 in the Exocrine Pancreas
… fashion. The pancreas also expresses the FGFR1/beta-klotho receptor complex that FGF21 binds to elicit downstream signaling. The physiological function of FGF21 in the exocrine pancreas is to stimulate digestive enzyme secretion by triggering intracellular calcium release through …
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Mechanisms Underlying Distinct Egfr Versus Fgfr-3 and -1 Dependency In Human Bladder Cancer Cells
… in BC cells, we demonstrated that FGFR3 and FGFR1 play largely non-overlapping roles in mediating proliferation and invasion in the distinct “epithelial” and “mesenchymal” subsets of human BC cells. Furthermore, we examined the sensitivities to FGFR3 and EGFR inhibition in a panel of human BC …
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Signaling mechanisms and developmental function of fibroblast growth factor receptors in zebrafish
… study, we show that the putative Fgf8 receptor Fgfr1 is duplicated in zebrafish and that it acts redundantly in the formation of the posterior mesoderm. Also, in overexpression studies we confirm the notion that receptor endocytosis influences Fgf8 signaling range. Through TILLING mutant …
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Metabolic regulation by nuclear receptor FXR and micro RNA-34a in health and disease
… patients. FGF21 binds to the adipocyte membrane FGFR1/βKL receptor complex, and activates Erk signaling which results in induction of FGF21 metabolic target genes. Besides βKL, I identified FGFR1 as a direct target of miR-34a. Other researchers had already reported that expression levels of βKL …
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Assessing the Mutational Landscape of BRAF- and KRAS-Wild Type Colorectal Cancer
… NRAS and TP53 mutations, as well as ERBB2, FGFR1, and EGFR amplifications, occurred more frequently in the wild-type cohort than the mutant cohort. We also assessed the number of cases in the wild-type cohort that would be eligible for clinical trials at Dana-Farber Cancer Institute. Using a …
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The Liver-Derived Endocrine Hormone FGF21 Alters Metabolism and Diurnal Behavior via the Nervous System
… hypothalamic nuclei of mice. Surprisingly, the FGFR1-IIIc/βKlotho complex is found in the suprachiasmatic nucleus (SCN), area postrema (AP), nucleus tractus solitarii (NTS), and nodose ganglion (cell body of vagus nerve), implicating roles in circadian and metabolic regulation. Results of …
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Reiterative FGF signaling determines the identity and morphology of the lacrimal gland
… to activate Ras-MAPK signaling downstream to Fgfr1 and Fgfr2 but not to Pdgfrα in the neural crest. By differential gene expression analysis, we identified homeodomain transcription factor Alx4 as the key effector of Shp2 signaling to control expression of Fgf10 in the periocular mesenchyme. …
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Abnormalities affecting tyrosine kinase signalling in atypical myeloproliferative disorders
… tyrosine kinase genes, notably PDGFRA, PDGFRB, FGFR1 and JAK2. However the majority of atypical MPDs still remain to be characterised and identification of patients harbouring fusions, particularly those involving the PDGF receptors is of increasing importance, as they are likely to be …
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A genetic analysis of somitogenesis in the Medaka (Oryzias latipes)
… regulates somite size also in medaka and that fgfr1 is the only FGF receptor expressed in the tailbud and somites. In class II medaka somite mutants, PSM prepatterning appears normal, whereas A-P polarity, boundary formation, epithelialization or the later differentiation of somites appears to …
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The Role of Acidic Fibroblast Growth Factor and Fibroblast Growth Factor Receptor 4 In High Grade Serous Carcinoma
… the proliferative effects of FGF1 in vitro. FGFR1, FGFR4 traps and anti-FGF1 antibodies did not show activity <em>in vitro</em>. OVCA432 transfected with the cignal lenti reporter system revealed significant activation of MAPK, NFkB and WNT pathways, western blotting confirmed the results. …