Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Fgf21"”.
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An investigation of acute exercise and FGF21.
Fibroblast growth factor 21 (FGF21) is a molecule that freely circulates in the blood and helps to regulate metabolism. Interest in FGF21 stems from its ability to promote weight loss and ameliorate type II diabetes in animal models. Recent findings have shown that blood levels of FGF21 increase …
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The Physiology and Pharmacology of FGF21 in the Exocrine Pancreas
… In the pancreas, fibroblast growth factor 21 (FGF21) is highly expressed, induced by feeding and acts in an autocrine/paracrine fashion. The pancreas also expresses the FGFR1/beta-klotho receptor complex that FGF21 binds to elicit downstream signaling. The physiological function of FGF21 in the …
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Understanding the Molecular Basis for FGF15/19 and FGF21 Actions on Energy Homeostasis
… expressed in transgenic mice. Another member, FGF21, has been shown to act as an insulin sensitizer pharmacologically by improving glucose tolerance and reducing insulin. The prevalence of metabolic disorders (e.g. type 2 diabetes) in today’s society has led to the investigation of these two …
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IMPACT OF DRP1 ACTIVATION, UNFOLDED PROTEIN RESPONSE INDUCTION AND FGF21 LEVELS IN DMD PROGRESSION
… muscle-specific induction of the stress mitokine FGF21. FGF21 detrimental effects have been reported concerning bone loss in mdx mice however it could also impact fibro-adipogenic progenitors differentiation considering that these cells express FGF receptor. We therefore decided to inhibit Drp1 …
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The Liver-Derived Endocrine Hormone FGF21 Alters Metabolism and Diurnal Behavior via the Nervous System
… endocrine hormone fibroblast growth factor 21 (FGF21) is induced in chronic fasting and acts as a global starvation signal. Previous studies focusing on FGF21 as an anti-diabetic drug indicate that FGF21 coordinates whole-body fat utilization and energy expenditure. However, its basic …
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Metabolic Regulation by Fibroblast Growth Factor 21
Fibroblast growth factor 21 (FGF21) is a secreted hormone that can beneficially regulate glucose and lipid homeostasis. Through a reverse endocrinology approach, we uncovered that FGF21 expression is transcriptionally regulated by the peroxisome proliferator activated-receptor alpha (PPARa) in …
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The Role Of Crebh In Hepatic Energy Regulation Under Metabolic Stress
… by activating fibroblast growth factor 21 (FGF21), a hepatic hormone that regulates whole-body energy homeostasis. Gain- and loss-of-function analyses indicated that CREBH and PPARA regulate each other for their expression. Activated CREBH protein interacts with PPARA under fasting or …
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Glucose and Lipid Dysregulation Following Loss of Hepatic Aryl Hydrocarbon Receptor in Mice.
… direct regulation of the metabolic hormone, FGF21. Using ChIP analyses and a luciferase reporter system we demonstrated that AhR directly regulates FGF21 at the gene level. The generation and utilization of AhR/FGF21 double conditional knockout mice demonstrated that FGF21 is responsible for …
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Protective effect of TM-25659, known as TAZ activator, on high-fat diet-induced insulin resistance in C57BL/6J mice
PART 1. TM-25659-induced activation of FGF21 level decreases insulin resistance and inflammation in skeletal muscle via GCN2 pathways 1 Ⅰ. INTRODUCTION 2 Ⅱ. MATERIALS AND METHODS 8 A. MATERIALS 9 B. METHODS 10 1. Preparation of PA 10 2. Cell culture 10 3. Immunoblot analysis 11 4. RNA isolation and …
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Einfluss von Kalorienrestriktion auf den Metabolismus
… auf. Wir untersuchten, ob das Hormon FGF21 Einfluss an dem Auftreten eines Diabetes mellitus Typ 2 (T2DM) oder des Metabolischen Syndroms (MetS) hat. Wir konnten zeigen, dass Personen, die später ein MetS entwickeln, bereits zu Studienbeginn einen erhöhten FGF21-Spiegel, einen höheren …
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Effects of nutrition, disease, and body condition score during the transition period on dairy cattle liver gene expression
… the expression and regulatory mechanism of FGF21 under early postpartal ketosis, L-carnitine infusion, a prepartal high energy diet and inflammatory mediators. Ketosis increased the expression and serum level of FGF2; however, a high plasma concentration of carnitine decreased hepatic …
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Non-invasive diagnosis of non-alcoholic fatty liver disease.
… 2 (TM6SF2) and fibroblast growth factor 21 (FGF21) variants as well as a panel of most abundant liver microRNAs. After univariate and multivariate analysis, we confirmed that GG genotype of PNPLA3 exerted a clear role in NASH development, and we identified the impact of a novel risk variant …
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Low-Protein Meal Challenge as a Predictor for Weight Loss Success in Severe Obesity
… indicate a single postprandial measurement of FGF21 following a high-caloric, low-protein test meal prior to starting a caloric restriction can be used as a blood-based biomarker for subsequent WL outcomes. A blunted postprandial response in FGF21 was shown to be predictive of reduced FM loss. …
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Metabolic regulation by nuclear receptor FXR and micro RNA-34a in health and disease
… since βKL is also a co-receptor for another FGF, FGF21, which acts on adipose tissue to regulate metabolism. FGF21 is also an endocrine hormone that has lipid-lowering and insulin-sensitizing beneficial effects when administered to obese patients. FGF21 binds to the adipocyte membrane FGFR1/βKL …
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Συσχέτιση της προσκόλλησης στη μεσογειακή δίαιτα με δείκτες φλεγμονής σε δείγμα παιδιών και εφήβων με παχυσαρκία και μεταβολικά σχετιζόμενη στεατωτική νόσο του ήπατος
… και ο ινοβλαστικός αυξητικός παράγοντας 21 (FGF21). Αποτελέσματα: Σύμφωνα με την αρχική έκδοση του δείκτη KIDMED, 42 (55,3%) παιδιά και έφηβοι/ες εμφάνισαν χαμηλή, 31 (40,8%) μέτρια και 3 (3,9%) υψηλή προσκόλληση στη ΜΔ. Με βάση τον αναθεωρημένο δείκτη KIDMED 2.0, 65 (85,5%) άτομα είχαν …
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Effects of prepartum dietary energy and lipid supplementation on hepatic transcriptome profiles in dairy cows during the transition period
… potential related nuclear receptors (NRs) and FGF21 modulating GH/IGF signaling in cows (n = 6/diet) assigned to a control (CON; NEL = 1.34 Mcal/kg DM) or moderate-energy (OVE; NEL = 1.62 Mcal/kg DM) diet during the entire dry period. All cows were fed a common lactation diet (NEL = 1.69 …
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Developmental signaling pathways in adult energy homeostasis
… The three endocrine FGFs, FGF19 (FGF15 in mice), FGF21, and FGF23 have well described roles in the regulation of metabolic processes in adults. While FGF23 is primarily involved in the regulation of phosphate and vitamin D homeostasis, FGF19 and FGF21 have shown similar pharmacological effects on …
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CARBOHYDRATES, LIPIDS AND BIOMARKERS OF TRADITIONAL AND EMERGING CARDIOMETABOLIC RISK FACTORS
… the hepatokine fibrogen growth factor 21 (FGF21). Furthermore, the second study scrutinised the food-groups, carbohydrates and subtypes of SFA that contributed to participants’ intake. The findings showed that for some markers, such as sdLDL-C the impact was unambiguous; all participants in …
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Nutrient sensing by the mTORC1 pathway in physiology
… driven by aberrant production of the hepatokine FGF21. We also found that leucine sensing is compartmentalized within the liver, which is established by zonated expression of Sestrin1 and Sestrin2 in the liver lobule and demonstrates an unappreciated spatial organization of nutrient sensing in …
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Molecular Mechanisms Governing the Pharmacology of LDT409 for the Treatment of Metabolic Disease
… of fasting-associated target genes (e.g., Fgf21, Pdk4), suggesting that LDT409 may mimic fasting to ameliorate fatty liver disease (Chapter 3). Lastly, we explored whether LDT409 induced a “fasting phenotype” to prolong the catabolic state and found that LDT409 yielded a similar response to …
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