Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Fgf15"”.
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Understanding the Molecular Basis for FGF15/19 and FGF21 Actions on Energy Homeostasis
… of the fibroblast growth factor superfamily. The FGF15/19 subfamily is composed of atypical FGFs lacking the heparin-binding domain, which enables them to act in an endocrine fashion by diffusing away from their tissues of origin. They signal through cell-surface receptors complexed with β-Klotho, …
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The Role of FGF Signaling in Retinal Development
… family of secreted polypeptide growth factors. Fgf15 is the major Fgf expressed during retinal development in mice. Fgf15 is an example of an FGF that has been shown to control proliferation, cell fate specification, differentiation and migration during development. In this thesis I used …
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The Role of OSTalpha/beta in Bile Acid and Lipid Metabolism
… Osta-/- mice was associated with decreased ileal Fgf15 mRNA expression, increased hepatic Cyp7a1 expression, increased fecal bile acid excretion, increased bile acid pool size, and restoration of intestinal cholesterol absorption. Ileal enterocyte Fgf15 mRNA expression was not significantly …
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Regulation of Bile Acid Biosynthesis by Orphan Nuclear Receptor Small Heterodimer Partner
… half-life of 20 to 30 minutes. Bile acids and FGF15/19 signaling pathways, and SHP ligand can dramatically increase SHP protein stability and abnormal regulation of SHP protein stability is associated with pathological disease conditions, indicating that regulation of SHP protein stability is a …
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Role of retinal inputs and astrocytes for the development of visual thalamus
… for astrocytic fibroblast growth factor 15 (FGF15) expression in developing visual thalamus. Ultimately, FGF15 serves as a potent motogen that is essential for thalamic interneuron migration. These data identify a novel morphogen-dependent and activity-independent mechanism that mediates …
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Neuronale in-vitro Differenzierung von murinen homozygoten Pbx1 Knock-out embryonalen Stammzellen : ein System zum Studium der Funktion und zur Identifikation potentieller Zielgene des Pbx1-Homeoboxproteins während der zellulären Differenzierung
… der zellulären Differenzierung traten bei WNT1, FGF15, IGF1, IGF2, IGF1R, IGF2R und Colipase besonders große Unterschiede im Vergleich der Genexpressionsmuster von PBX1(+/+)-, PBX1(+/-)- und PBX1(-/-)-ES-Zellen auf. <br>Die Ergebnisse unserer Untersuchungen lassen den Schluss zu, dass …
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Effects of diet and loss of ovarian hormone production on adiposity, inflammation, cecal integrity, and gut microbial communities of rodent models
… X receptor (FXR) and fibroblast growth factor (FGF15) was observed in the OVX mice compared to SHM, suggesting an interaction between estrogen and the FXR-FGF15 pathway that is known to affect bile acid synthesis. PCoA of weighted and unweighted UniFrac distances of cecal microbiota revealed a …
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Molecular analysis of transcriptional properties of Pbx1 and E2a-Pbx1
… of EF-9, but dispensable for activation of FGF15 target genes in NIH3T3 fibroblasts. Furthermore the LDFS motif of E2a is essential for inducing proliferation of NIH3T3 fibroblasts but dispensable for blocking differentiation of myeloid progenitors. These data suggest that E2a-Pbx1 activates …
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Developmental signaling pathways in adult energy homeostasis
… family, FGF19. The three endocrine FGFs, FGF19 (FGF15 in mice), FGF21, and FGF23 have well described roles in the regulation of metabolic processes in adults. While FGF23 is primarily involved in the regulation of phosphate and vitamin D homeostasis, FGF19 and FGF21 have shown similar …