Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Fgf10"”.
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Expression and Putative Functions of Fibroblast Growth Factor 10 (Fgf10) in Developing and Adult Skeletal Muscles
… This study was prompted by the discovery of Fgf10 expression in adult mouse skeletal muscles. Using an Fgf10-nLacZ reporter line, I set out to characterize this novel expression pattern in order to learn more about Fgf10’s putative function/s. I have shown that intriguingly Fgf10 is only …
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Reiterative FGF signaling determines the identity and morphology of the lacrimal gland
… secretes the chemo-attractive signal of Fgf10, which binds to epithelial Fgfr2b and co-receptor heparan sulphate proteoglycans, to promote budding and branching morphogenesis of the lacrimal gland. However, the mechanism by which Fgf10 expression is regulated within the neural crest and …
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Development of the Inner Ear: a Molecular, Cellular and Evolutionary Approach to Understanding the Development of the Inner Ear with an Emphasis on the Roles of Fgf10 and Foxgl
(First paragraph) Hearing loss is a condition affecting people of all ages and can be categorized as either conductive or sensorineural. Conductive hearing loss is caused by pathology of the middle ear and will not be addressed in this volume. Our focus here is on sensorineural hearing loss, or …
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Development of Vessels, Airways and Cartilage Rings: The role of T-box genes
… the expression of mesenchymal markers Wnt2 and Fgf10, as well as Fgf10 target genes in the epithelium, Bmp4 and Spry2, is downregulated. Lung branching undergoes arrest ex vivo when Tbx4 and Tbx5 are both completely lacking. Lung-specific Tbx4 heterozygous; Tbx5 conditional null mice die soon …
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The Roles of EGFR and FGFR2 in Cell Shape Maintenance of Human Lung Tip Progenitor Epithelial Cells
… cells. I have found that EGF, FGF7 and FGF10 have distinct functions in the regulation of lung tip progenitor cell shape. FGF7 promotes columnar cell shape in primary tip progenitor cells, whereas EGF and FGF10 cannot. FGF7 activates sustained MAPK/ERK and PI3K/AKT pathways when assayed …
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A novel role for Sprouty2 in co-ordinating airway and vascular growth of the fetal lung.
… tube elongation, Fibroblast Growth Factor 10 (FGF10) and the pro-vasculogenic transcription factor, Hypoxia Inducible Factor 1a (HIF-1a). The FGF receptor antagonist, Sprouty2 (SPRY2), influences the duration of this signalling activity and thus governs periodical airway and vascular branching. …
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Hox Targeting in Vertebrate Forelimb Induction: Expression and Comparative Genomics
… the forelimb (<em>Tbx5, Salli, Sall4, and Fgf10</em>) have been predicted through comparative genomics, including the use of sequence alignment, phylogenetic footprinting, and related analyses. We have also used comparative genomics to predict potential Lmx1b core binding sites in the Emx2 …
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Modulation of lung development by In utero gene transfer
… morphogenesis, fibroblast growth factor 10 (FGF10). We observed that FGF10 mesenchymal overexpression, on the fetal rat lung, resulted in the induction of consistent patterns of malformation, the appearance of which were developmental stage and location dependent. These malformations, in …
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Exploring Molecular Mechanisms Controlling Skin Homeostasis and Hair Growth. MicroRNAs in Hair-cycle-Dependent Gene Regulation, Hair Growth and Associated Tissue Remodelling.
… that miR-31 negatively regulates expression of Fgf10, the components of Wnt and BMP signalling pathways Sclerostin and BAMBI, and Dlx3 transcription factor, as well as selected keratin genes. Luciferase reporter assay revealed that Krt16, Krt17, Dlx3, and Fgf10 serve as direct miR-31 targets. In …
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The role of Ten Eleven Translocation enzymes in the hair follicle mesenchyme
… Examples include AlPl, LEF1, BMP4/6/7, FGF10, BMPR1A and PDGFA. Additionally, by way of siRNA and conditional Tet2 knockout data in dermal fibroblasts, it was found Tet2 regulates signature DP genes such as Bmpr1a, ALPL, Tcf4 and SOX2.
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The Misexpression of Sonic Hedgehog Leads to Digit Duplication
… in-situ hybridization with probes for Fgf8, Fgf10 and Shh. Taken together, morphological and molecular expression analysis data supports our hypothesis that mis-expression of Shh leads to digit duplication defects.
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Characterization of the early stages of long bone regeneration in fractures and critical size defects in Xenopus Laevis
… scaffolds loaded with growth factors BMP4 and FGF10 were implanted in the critical defect site in the tarsus of the Xenopus Laevis. Defects in control frogs were left empty. Fractures were also induced in some frogs to study the mechanisms of endochondral ossification. The limbs were harvested …
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Transcriptional profile of c-kit positive cardiac stem-progenitor cells (c-kitpos eCSCs) isolated from the four chambers of the adult human heart
… Hand2, Pitx2, Tbx5, Tbx20, Hrt1, Hrt2, Fgf8, Fgf10, and Isl1 were found at differential levels in c-kitpos CSCs isolated from the four cardiac chambers. Conclusion: This study is the first to show that c-kitpos eCSCs derived from human adult cardiac samples, do not appear to have a …
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BMP Signaling through BMPR1A is Required for Establishment of Pancreatic Laterality
… of genes that require Bapx1, including Fgf9 and Fgf10. Additionally, deletion of Bmpr1a also leads to misregulation of Barx1, another gene with SMP restricted expression. Deletion of BmpR1a specifically from the pre-pancreatic endoderm or endothelial (aorta) cells did not show defects with …
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Cellular principles of Xenopus appendage regeneration
… factors can be overridden by the application of FGF10 which operates upstream of the effect of NOGGIN, prevents chondrogenesis, and restores regeneration. As mammals have AER in their embryonic development, revealing their connection to chondrogenesis opens new avenues for research aiming to …
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Identifying Novel Molecular Mechanisms Underlying Lateral Line Organ Development in Sterlet
… lateral line system. Of these, five (Dner, Fgf10, Ngfr, Cbln18 and Kit) were expressed within developing neuromasts but not AOs, and four (Dll4, Axin2, Omg and Gpr52) within developing AOs but not neuromasts. (Other genes with specific expression patterns were expressed in non-lateral line …
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The role of notch signaling in the development of the hypothalamic-pituitary axis and arcuate nucleus
… to pituitary development, such as OTX2 and Fgf10, coincident with reduced survival of pituitary progenitors. Taken together, our results indicate that Rbpjκ- dependent Notch signaling within the developing hypothalamus is not necessary for pituitary development, but persistent Notch …
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Phenotypic analysis of human stem cells and their differentiation potential towards pancreatic cells
… factor (FGF)-10, and then KAAD-cyclopamine, FGF10 and all trans-retinoic acid. These PDX-1-expressing cells represent a source of pancreatic progenitor cells differentiated up to the posterior foregut stage. HASCs purchased from Celprogen Inc. displayed the greatest potential to be …