Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Fgf1"”.
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The Role of Acidic Fibroblast Growth Factor and Fibroblast Growth Factor Receptor 4 In High Grade Serous Carcinoma
… particular acidic fibroblast growth factor (<em>FGF1</em>) has been demonstrated to be one of the driving genes in mediating the observed prognostic effect of the amplicon in ovarian cancer patients. This study seeks to further validate the prognostic value of fibroblast growth receptor 4 …
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The B55α/PP2A Holoenzyme in Cell Cycle Exit, Maturation/Differentiation, and Cancer
… elucidated. In this thesis, I show that FGF1, which induces maturation and cell cycle exit in chondrocytes, triggers rapid accumulation of p107/PP2A/B55α complexes coinciding with p107 dephosphorylation without an increase in B55α protein expression in RCS cells. Reciprocal solution-based …
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Genetic dissection of essential hypertension and familial intracranial aneurysm
… sample. The fibroblast growth factor 1 gene, FGF1, is located at the centre of the QTL. This gene had previously been cited as a putative blood pressure candidate gene in the 5q region but not studied in humans. With roles in endothelial cell proliferation, possible oxidative stress defence …
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Identification of novel components in fibroblast growth factor signalling
… Janus non receptor tyrosine kinases decreased FGF1-induced tyrosine STAT3 phosphorylation. The findings suggested that FGFR kinase activity was mandatory for physical association between FGFR and STAT3 and its subsequent tyrosine activation by Src and Jak kinases. Moreover, Src and Jak2 were …
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FGF signaling in Xenopus laevis lens regeneration
… The described experiments found that FGF1, FGF8, and FGF9 mRNA are more expressed in the retina than the cornea, indicating that they may be the signal for inducing lens regeneration. Three receptor mRNAs (FGFR1, FGFR2, and FGFR3) were found to be expressed in the cornea. Second, the …
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Glycosaminoglycan regulation of cell function
… can define the responsiveness of a given cell to FGF1 and FGF2 through multiple receptor isoforms. Stromal cell derived HSGAGs were also identified as critical regulators of tumor cell growth and metastasis, effecting not only FGF2., but also 1-integrin signaling.
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Engineering functional kidney tissue using human iPS cells
… them. I show that the combination of GDNF, FGF1, CHIR99021 and RA was able to induce branching in the isolated UBlike structures. The ability to isolate pure differentiated UB structures from surrounding contaminant tissue and to induce them to branch forming contiguous collecting duct tree …