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Showing 1 to 12 of 12 for “"Fetuin-A"”.
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Fetuin-A: a novel marker for obesity and associated comorbidities
… and monitoring of at-risk populations. Fetuin-A (FetA) has shown promise as a potential marker of insulin resistance yet much about this hepatokine remains unknown. The overarching goal of this research is to understand whether FetA may be a novel marker of obesity and obesity-associated …
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Die Bedeutung von Fetuin-A für Proliferation und Fibrogenese im Knockout-Modell
… model of the mouse we examined the effect of fetuin-A for physiological proliferation and pathological fibrogenesis of the liver. The rational was, that fetuin-A as a TGF-beta antagonist possibly adjusts the effects on proliferation and fibrogenesis of this growth factor and therefore the loss …
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Biochemische und funktionelle Charakterisierung einer gerichteten Gendeletion (Knockout) von Fetuin-A in Mäusen
… mineral precipitation. The serum protein fetuin-A/a2-HS glycoprotein (Ahsg) can transiently inhibit the calcium phosphate precipitation in vitro by binding the crystal nucleus, inhibiting it's growth and forming a soluble colloid. The backcrossing of Ahsg knockout mice onto two defined …
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Fetuin-A als Risikomarker bei Patienten mit Niereninsuffizienz : Nephelometrie als neues Nachweisverfahren bei Risikokollektiven
… serum. The calcification inhibiting protein ahsg/fetuin-a accounts for 50% of the precipitation inhibitory effect in serum and acts in vivo and in vitro. Additionally ahsg/fetuin-a is a negative acute phase protein whose concentration is downregulated during acute or chronic inflammation. In this …
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Der therapeutische Effekt von Calcimimetika auf die Progression extraossärer Kalzifikation und ossärer Dekalzifikation bei Ahsg/Fetuin-A-defizienten Mäusen
… product can be achieved more frequently. The fetuin-knockout mouse model represents a patient suffering from chronic renal failure and its resulting consequences which made it possible to analyse additional effects of the latest calcimimetic agent R-641. The potency of the new compound was …
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Gene deletion and functional analysis of Fetuin-B
… the physiological function of the serum protein fetuin-B and comparing it with its closest family member fetuin-A. Fetuin-A is known to be an inhibitor of calcium and phosphate precipitation in vivo. This has been shown in a fetuin-A-deficient animal model. In this study, the serum protein …
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Structural analysis of nanoparticles by small angle X-ray scattering
… in looking for the influence of a protein, Fetuin-A, also called ahsg, onto the calci_cation at early stage. For the purpose, calcium and phosphate ions were mixed with or without the presence of Fetuin-A in a buffr solution of pH=7.4. In a first step, DLS measurements were realized to …
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Discovery of Glyco-biomarkers for Diabetes and Complications in Diabetes
… lectin (AAL) pull-down experiments. Fucosylated fetuin-A and α-1-acid glycoprotein were selected as candidate glyco-biomarkers. A lectin ELISA using F(abʹ)2 fragments as capture antibody was developed to validate the fucosylation changes by screening 20 normal and 20 diabetic patient plasma …
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Mineralized Bionanoparticle Pickering Emulsions
… investigated in this work. Proteins (HSA, BSA, fetuin-A), protein cages (ferritin) and plant viruses (CPMV, TYMV, TMV) were employed to produce functional nanopatterned surfaces and interfaces by means of Pickering emulsions which were employed in biomimetic hydroxy apatite mineralization to …
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Uraemic vascular damage and calcification in children with chronic kidney disease
… of the circulating calcification inhibitors, fetuin-A, osteoprotegerin and Matrix Gla-protein, may influence an individual patients’ susceptibility to calcify, and but have not been described in children. I found that these levels influenced vascular stiffness and calcification, and that there …
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Cloning and targeted deletion of the mouse histidine rich glycoprotein gene and functional characterization of HRG in mice
… to belong to the cystatin superfamily like fetuin-A, fetuin-B and kininogen. Mature HRG circulates in blood at relatively high concentrations of up to 150 mg/l (~2 µM). HRG is exclusively synthesized in the liver, but it is stored in platelets and megakaryocytes where it can be released …