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Showing 1 to 20 of 20 for “"Fetuin"”.
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The plasma protein fetuin: common structural features of the mammalian fetuin family
… expression of the bovine plasma glycoprotein fetuin and its homologues in other species has been examined. From the known partial amino acid sequence of bovine fetuin, degenerate oligonucleotide probes were designed. These probes were end-labelled using 14 polynucleotide kinase and were used …
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Gene deletion and functional analysis of Fetuin-B
… the physiological function of the serum protein fetuin-B and comparing it with its closest family member fetuin-A. Fetuin-A is known to be an inhibitor of calcium and phosphate precipitation in vivo. This has been shown in a fetuin-A-deficient animal model. In this study, the serum protein …
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Fetuin-A: a novel marker for obesity and associated comorbidities
… and monitoring of at-risk populations. Fetuin-A (FetA) has shown promise as a potential marker of insulin resistance yet much about this hepatokine remains unknown. The overarching goal of this research is to understand whether FetA may be a novel marker of obesity and obesity-associated …
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Die Bedeutung von Fetuin-A für Proliferation und Fibrogenese im Knockout-Modell
… model of the mouse we examined the effect of fetuin-A for physiological proliferation and pathological fibrogenesis of the liver. The rational was, that fetuin-A as a TGF-beta antagonist possibly adjusts the effects on proliferation and fibrogenesis of this growth factor and therefore the loss …
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Biochemische und funktionelle Charakterisierung einer gerichteten Gendeletion (Knockout) von Fetuin-A in Mäusen
… mineral precipitation. The serum protein fetuin-A/a2-HS glycoprotein (Ahsg) can transiently inhibit the calcium phosphate precipitation in vitro by binding the crystal nucleus, inhibiting it's growth and forming a soluble colloid. The backcrossing of Ahsg knockout mice onto two defined …
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Fetuin-A als Risikomarker bei Patienten mit Niereninsuffizienz : Nephelometrie als neues Nachweisverfahren bei Risikokollektiven
… serum. The calcification inhibiting protein ahsg/fetuin-a accounts for 50% of the precipitation inhibitory effect in serum and acts in vivo and in vitro. Additionally ahsg/fetuin-a is a negative acute phase protein whose concentration is downregulated during acute or chronic inflammation. In this …
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Der therapeutische Effekt von Calcimimetika auf die Progression extraossärer Kalzifikation und ossärer Dekalzifikation bei Ahsg/Fetuin-A-defizienten Mäusen
… product can be achieved more frequently. The fetuin-knockout mouse model represents a patient suffering from chronic renal failure and its resulting consequences which made it possible to analyse additional effects of the latest calcimimetic agent R-641. The potency of the new compound was …
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Structural analysis of nanoparticles by small angle X-ray scattering
… in looking for the influence of a protein, Fetuin-A, also called ahsg, onto the calci_cation at early stage. For the purpose, calcium and phosphate ions were mixed with or without the presence of Fetuin-A in a buffr solution of pH=7.4. In a first step, DLS measurements were realized to …
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Discovery of Glyco-biomarkers for Diabetes and Complications in Diabetes
… lectin (AAL) pull-down experiments. Fucosylated fetuin-A and α-1-acid glycoprotein were selected as candidate glyco-biomarkers. A lectin ELISA using F(abʹ)2 fragments as capture antibody was developed to validate the fucosylation changes by screening 20 normal and 20 diabetic patient plasma …
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Mineralized Bionanoparticle Pickering Emulsions
… investigated in this work. Proteins (HSA, BSA, fetuin-A), protein cages (ferritin) and plant viruses (CPMV, TYMV, TMV) were employed to produce functional nanopatterned surfaces and interfaces by means of Pickering emulsions which were employed in biomimetic hydroxy apatite mineralization to …
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Characterization of Attachment and Receptor Isolation of Infectious Pancreatic Necrosis Virus to Chse-214 Cells
… viruses absorbed to Concanavalin A, lentil or fetuin treated cells, indicating the cellular receptor sites may contain a structural sialo-glycoprotein similar to glycophorin A. The IPNV receptor is suggested to reside in a coated pit covered by a masking protein, which is removed by low …
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Novel fusion proteins based on recombinant lectins for delivery of a cytotoxic peptide specifically to cancer cells
… 4B column coupled with degalactosylated fetuin so as to confirm the sialic acid binding activity of MLB. The binding of MLB+GFP fusion proteins to the membrane glycans of human cancer cells was also confirmed through the treatment of human metastatic melanoma cells with the fusion protein …
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Cloning and targeted deletion of the mouse histidine rich glycoprotein gene and functional characterization of HRG in mice
… to belong to the cystatin superfamily like fetuin-A, fetuin-B and kininogen. Mature HRG circulates in blood at relatively high concentrations of up to 150 mg/l (~2 µM). HRG is exclusively synthesized in the liver, but it is stored in platelets and megakaryocytes where it can be released …
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Uraemic vascular damage and calcification in children with chronic kidney disease
… of the circulating calcification inhibitors, fetuin-A, osteoprotegerin and Matrix Gla-protein, may influence an individual patients’ susceptibility to calcify, and but have not been described in children. I found that these levels influenced vascular stiffness and calcification, and that there …
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Genetic mapping and functional studies of a natural inhibitor of the insulin receptor tyrosine kinase: the mouse ortholog of human [alpha subscript 2]-HS glycoprotein
Fetuin/α2-HS glycoprotein (α2-HSG) homologs have been identified in several species including rat, sheep, pig, rabbit, guinea pig, cattle, mouse and human. Multiple physiological roles for these homologs have been suggested, including ability to bind to hydroxyapatite crystals and to specifically …
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Zur molekularen Topologie der Bindung natürlicher und rekombinanter Varianten von Alpha 2 -HS-Glycoprotein-Feturin an Hydroxylapatit
The plasma protein alpha-2-HS-glycoprotein (AHSG)/fetuin transiently inhibits the calcium phosphate precipitation from supersaturated solution. The unique structural motif within the first domain of AHSG mediating the inhibition of precipitation was studied by use of structure-function relations of …
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Development and application of tools for glycan characterization
… method, the O-linked glycans of bovine mucin and fetuin were successfully profiled, and the analysis of the former provided the motivation for a second project focused on the significance of goblet cells and mucins in influenza infection. This project explored the potential benefits of a …
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Host-Parasite Interrelations: Bacterial Adherence to and Invasion of Epithelial Cells
… concanavalin A (ConA). Glycoproteins (ovomucoid, fetuin, mucin, ovalbumin) inhibited binding by P.IIa, WGA, and ConA to variable degrees. HeLa cell glycopeptides, generated by pronase digestion of chloroform:methanol-extracted cells, were tested for their ability to inhibit binding by P.IIa to …