Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Fetal aneuploidy"”.
-
Impact of prenatal screening on future resource utilization in pregnancy
… first recommended that prenatal screening for fetal aneuploidy be offered to all pregnant women. This is an important change in clinical obstetrics as previously these services had only been routinely offered to women who would be 35 or older at the time of delivery; however, maternal age alone …
-
Cell-free fetal DNA (cffDNA) enrichment for non-invasive prenatal testing (NIPT): a comparison of molecular techniques
Prenatal assessment of fetal health is routinely offered throughout pregnancy to ensure that the most effective management can be provided to maintain fetal and maternal well-being. Currently, invasive testing is used for definitive diagnosis of fetal aneuploidy, which is associated with a 1% risk …
-
Patient Perception of Negative Non-Invasive Prenatal Testing Results
… prenatal testing (NIPT) uses cell-free fetal DNA to assess for fetal aneuploidy during pregnancy. NIPT has higher detection rates and positive predictive values than previous methods; however, NIPT is not diagnostic. Studies suggest patients may underestimate the limitations of prenatal …
-
Patient Understanding of Fetal Sex Versus Gender in the Context of Routine Cell-Free DNA Screening
… is the current standard of care to screen for fetal aneuploidy using cell-free DNA (cfDNA). NIPT screens for sex chromosome aneuploidies (SCAs) and in doing so, can predict fetal chromosomal sex. Despite sex and gender being distinct concepts, many patients refer to NIPT as “the gender test” …
-
Obstetrician and Gynecologist Utilization of The Nipt Expanded Testing Option
… testing (NIPT) enables the detection of common fetal aneuploidies such as trisomy 21, trisomy 18, trisomy 13, and sex chromosome abnormalities via analysis of cell-free fetal DNA circulating in maternal serum. Although the accuracy of NIPT for fetal aneuploidy is expected to be higher than that …
-
the Order of Genetic Counseling and Ultrasound In the Second Trimester For Patients Screen Positive Down Syndrome: Effects On Patient Knowledge, Anxiety, Decision-Making, and Satisfaction
… screening results indicate an increased risk for fetal aneuploidy be offered a detailed ultrasound exam, diagnostic testing, and genetic counseling as follow-up to their positive screening result (ACOG Committee on Practice Bulletins, 2007). The current study examined if the relative order of …
-
Expanding the accuracy, resolution, and breadth of cell-free DNA investigation
… statistical methods for inference of the entire fetal genome at the single nucleotide level, including both inherited and de novo variation. I show that the use of parental haplotypes and maternal cfDNA in a hidden Markov model can yield highly accurate prediction of inherited fetal genotypes. I …
-
Molecular Pathology: Potential Biomarkers For The Detection Of Down Syndrome Pregnancies
… trisomy 21, is the most common non- lethal fetal aneuploidy that affects 1 in 800 live births. The disease appears mostly due to the existence of an extra copy of chromosome 21. In the UK, the screening of DS is offered to all pregnant women in the antena- tal care program to assess the risk …