Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Fetal Circulation"”.
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Methadone metabolism in placentas from preterm pregnancies
… affect the concentration of the drug within the fetal circulation. Accordingly, this might be an important factor affecting the occurrence and intensity of neonatal abstinence syndrome.
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Investigating thyroid hormone transport and regulation in chorionic somatomammotropin RNAi models of intrauterine growth restricted pregnancies
… a decrease of thyroxine levels in maternal and fetal circulation. Transthyretin (TTR) is a TH binding molecule produced by trophoblast cells that preferentially binds T4 and may shuttle T4 through the placenta. It was our objective to better understand thyroid hormone transport during late …
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Placental P-glycoprotein: Role in disposition of medications administered during pregnancy
The placenta supports fetal growth and regulates the bio-distribution of substances between the maternal and fetal circulation. Active efflux transporters in the placental apical membrane are involved in placental elimination of compounds and thus fetal protection. The goal of this investigation …
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Genetic Determinants of ABCB1 Promoter Activity and Their Effects on Environmental Exposure
… xenobiotic transfer from the maternal to the fetal circulation. A major placental efflux transporter is P-gp, which is encoded by the ABCB1 gene. Many medications prescribed to pregnant women, such as antibiotics for acute illness or medications used to treat chronic diseases including asthma …
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Prenatal Cardiovascular Physiology and Early Neurodevelopment in Cyanotic Congenital Heart Disease
… CHD. Recently, our group developed an updated fetal cardiovascular magnetic resonance (CMR) approach to non-invasively assess patient-specific hemoglobin concentration, in addition to vessel blood flow and oxygen saturation to measure oxygen transport across the fetal circulation. Among fetuses …
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Pharmacokinetics of Bupropion and its Pharmacologically Active Metabolites in Pregnancy
… the matching maternal plasma, suggesting limited fetal exposure. In addition, we found that the concentrations of OHBUP and TB in the fetal circulation could be predicted from those in the maternal plasma. Further, bupropion and its metabolites were determined in the amniotic fluid, suggesting …
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Feto-placental vascular structure and function: comparison of within and between species variations
… thesis focuses on the structure and function of fetal circulation within the placenta, using imaging data to develop a data-to-model pipeline for understanding differences in human and rodent fetoplacental vascularisation. This thesis is motivated by a need to understand species differences, as …
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The impact of placental SLC2A3 (GLUT-3) RNA interference on fetal growth and physiology at mid-gestation in sheep
Glucose is the primary energy substrate for fetal oxidative processes and growth. In order for glucose to be transported from maternal to fetal circulation in the ruminant placenta, it must be sequentially transported by SLC2A1 (GLUT-1) on the maternal-fetal syncytial layer, then by SLC2A3 (GLUT-3) …
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The role of insulin-like growth factors in the fetus
Fetal substrate supply is important in the regulation of fetal growth. The insulin-like growth factors (IGFs), insulin and placental lactogen (PL) may be important mediators in fetal growth regulation. However, nutritional regulation of circulating concentrations of IGFs, their binding proteins …
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The Role of Mitochondria in Oxygen Sensing of the Ductus Arteriosus and Fetal Pulmonary Arteries
… and other oxygen sensing tissues. However, the fetal PA oxygen response has been little studied, the identity of the DA oxygen sensor remains elusive, and the basis for the opposing oxygen responses of the DA (vasoconstriction) and PA (vasodilation) are unknown. With the transition from fetal …
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Maternal Vascular Compliance of Placentas in Rabbits
… the important part it plays in affecting circulation, compliance has been studied in the fetal circulation of the placenta, the fetal placental vascular bed, and the umbilical vasculature, The purpose of the present study was to determine maternal placental vascular compliance.</p> …
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The effect of maternal obesity/GDM and metformin intervention on maternal, placental and fetal health
… in obese and GDM pregnancies, which affects fetal growth and development. Recent years have implicated placental extracellular vesicles (EV) in fetal-maternal communication, with their microRNA (miRNA) content affecting maternal metabolism and potentially the fetus. Overall, it is …