Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Ferroptosis"”.
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Ferroptosis: A Novel Form of Cancer Cell Death Induced by the Small Molecule Erastin
… We refer to this type of cell death as ferroptosis. In this thesis I characterize ferroptosis with respect to other cell death phenotypes and find that it is distinct from previously described cell death paradigms such as apoptosis, autophagic cell death, accidental necrosis, and various …
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Examining the Impact of PUFAs and the Role of Autophagy in Iron-Induced Ferroptotic Cell Death
Ferroptosis, an iron-dependent non-apoptotic cell death involves lipid peroxidation and associates with cardiometabolic disease and cancer. I established a model of iron overload in L6 cells and measured cell viability, toxicity and lipid peroxidation. Importantly, in PUFA pre-treated cells, the …
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The Regulation of Cellular Iron Metabolism
… part of a regulated cell death pathway, termed ferroptosis. This pathway is typically suppressed in tumours, but can be induced by cytotoxic T cells and contribute to anti-tumoural immunity. It is therefore essential to understand how cellular iron levels are controlled. In this thesis, I …
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Identifying dietary additive regulated mechanisms impacting intestinal epithelial cell responses and inflammatory processes
… name a few, the study reveals that p80 triggers ferroptosis—a type of cell death associated with iron-dependent lipid peroxidation—causing mitochondrial damage. Interestingly, p80 did not seem to activate the inflammatory response in the cells. The second part of the thesis explores the role of …
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Using high-content subcellular proteomics to identify x-ray-induced protein trafficking
… 12hr timepoint, several proteins involved in the ferroptosis pathway, a type of programmed iron-dependent cell death, had changed localisation, 3 including a key ferroptosis suppressor. Immunofluorescence microscopy was used to validate several of these differentially localised ferroptosis …
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ANTIFUNGAL ACTIVITY OF NATURAL AND NATURAL-INSPIRED BIOACTIVE COMPOUNDS TO CONTROL THE RICE BLAST FUNGUS
… retention of strobilurin-like mechanisms. Ferroptosis, an iron-dependent form of regulated cell death, was investigated for its role in appressorium maturation. A series of benzamides containing chelating catechol moieties effectively suppressed appressorium formation, with activity …
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STUDY ON HISTONE DEACETYLASE 3 AND ITS PHARMACOLOGICAL REGULATION IN THE PATHOPHYSIOLOGY OF ADIPOSE TISSUE
… necessary for healthy adipose tissue expansion. Ferroptosis is an iron-dependent programmed cell death characterized by the accumulation of lipid peroxides and may have a role in pathophysiology of adipose tissue. Aim: This thesis is focused on the role of histone deacetylase 3 (HDAC3) in WAT …
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Resistance to HER2-targeted therapies in HER2-positive breast cancer
… possibility of HER2-targeting therapies inducing ferroptosis, an iron-dependent form of cell death. Sapatinib-treated tumours from mice on a iron-low control diet had increased cyclooxygenase 2 (COX2), a marker of ferroptosis, which was not seen in sapatinib-treated tumours from mice on an …
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Modelling the effect of loss of function CREBBP mutations in the evolution and treatment of B cell acute lymphoblastic leukaemia (B-ALL)
… hypothesised mechanism relies on the intrinsic ferroptosis sensitivity of CREBBP mutated cell lines to ferroptotic programmed cell death. Due to this, a Venetoclax resistance could be overcome by ferroptotic inducers such as Erastin.
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Investigating inhibition of porphyrin (heme) synthesis as a novel treatment option for prostate cancer
… is not as a result of apoptosis, necroptosis or ferroptosis, suggesting a different type of cell death is occurring. This study also aimed to express and purify the enzymes responsible for the first step in heme synthesis, performed by ALAS 1 or 2. ALAS 2 T was able to be purified in Rosetta …
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Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death
… cell lines, it is not the sole contributor as ferroptosis inhibitors do not fully mitigate membrane permeability. We go on to test different membrane channels and do not see decreases in membrane permeability, potentially indicating pathway-independent effects of temperature on membrane …
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Metabolically rewiring pancreatic stromal cells in pancreatic cancer
… effects were mediated by the induction of both ferroptosis and apoptosis. Lastly, we observed inhibition of SLC7A5 in CA-PSCs reduced proliferation by inducing senescence and limiting leucine uptake. In summary, this thesis demonstrated inhibition of SLC7A11/SLC7A5 has the potential to target PC …
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MUTANT P53 AS A THERAPEUTIC TARGET IN CANCER
… for p53 activation and improper regulation of ferroptosis. This work identifies lexibulin as a chemotherapy that preferentially targets P47S tumor cells and describes its mechanism of action as a potential personalized therapeutic approach in individuals harboring the P47S variant. We …
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An integrated multi-omics approach to improve our understanding of ageing and neurodegeneration
… synthesis of a neurotransmitter (GABA), while ferroptosis might represent another mechanism of host-microbiome interaction contributing to ageing and PD associated decline in cognition.
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Methods Development in Inflammatory Bowel Disease
… receptor"; "NF-kappa B signaling pathway"; "Ferroptosis"; and "Epithelial cell signaling in Helicobacter pylori infection". A second method utilized the largest African American population of IBD patients to date in a dense endophenotype study. Using a stratified analysis to test for …
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The Role of Compartmentalized Metabolism in Cellular Metal Homeostasis
… starvation and resistant to iron overload and ferroptosis. As mitochondria are the main sites of iron assimilation, I also characterized mitochondrial proteomic changes upon altered cellular iron. Here, I identified a mitochondrial solute transporter, SLC25A39, whose protein stability was …
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From proteomics to biotechnology. using the resurrection plant eragrostis nindensis to genetically engineer drought tolerant crops
… osmotic stress. For instance, the prevention of ferroptosis and accumulation of raffinose synthase and starch synthase in the NST exclusively illustrated that small and subtle increases in protein abundance are likely responsible for enabling resurrection in the NST and not in the ST, which we …
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Discovery and biological evaluation of ferroptocide
The chemical diversification of natural products provides a robust and general method for creation of stereochemically complex and structurally diverse small molecules. The resulting compounds have physicochemical traits different from those in most screening collections, and as such are a rich …
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DEVELOPMENT OF PHYSIOLOGICAL CULTURE SYSTEMS TO ACCESS UNTAPPED OVARIAN RESERVES FOR IMPROVING REPRODUCTIVE EFFICIENCY
… transcriptome and network analyses indicate that ferroptosis and autophagy are the elected programmed cell death mechanisms active in isolated primordial follicles cultured in vitro. Furthermore, we delineate the essential genes and pathways orchestrating the consecutive developmental transitions …
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ELUCIDATING THE ROLE OF HET0016 IN AMELIORATING 20-HETE INDUCED OXIDATIVE STRESS AND LIVER INJURY IN B-THALASSEMIA: A NOVEL THERAPEUTIC TARGET
… the effects of 20-HETE inhibition on the ferroptosis pathway were examined by measuring the mRNA and protein expression levels of glutathione peroxidase 4 (GPX4) in addition to measuring total glutathione (GSH) levels. Results: In Hbbth3/+ mice, there was an increase in intracellular ROS …
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