Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"Fenofibrate"”.
-
Studies investigating the impact of select genotypes on the pharmacological effect of fenofibrate
… that tested the effect of combining statins and fenofibrate, posed a challenge in using this antidyslipidemic medication. One significant challenge of using fenofibrate is the high inter-subject variability in lipid response, which can range from -82 to 132% for triglyceride change from baseline. …
-
The interaction between glucose and fat metabolism and insulin resistance in severely burned children and the metabolic effects of fenofibrate
… proliferator activating receptor alpha agonist fenofibrate. \r\nThe final two studies focused on burn trauma in children. Children who experience severe flame burn rapidly develop insulin resistance and hyper-metabolic fat, protein and glucose regulation. This insulin resistance has been linked …
-
Role of peroxisome proliferator-activated receptors in mechanisms of rejection in heart transplantation
… (TxAA). Four different PPAR agonists (fenofibrate and Wy14643 for PPARα; BRL69453 and 15-deoxy-[delta]¹⁴̹⁶ Prostaglandin-J₂ for PPAR[gamma]) in an in vitro model of the alloresponse all demonstrated a robust and substantial attenuation of IFN[gamma], a cytokine that critically affects …
-
THE ANTI-INFLAMMATORY AND PRO-NEUROGENIC ROLE OF PPARα IN MODULATING RADIATION-INDUCED BRAIN INJURY
… BV-2 cells with the PPARα agonists, GW7647 and Fenofibrate significantly inhibited the radiation-induced microglial pro-inflammatory response, in part, via decreasing i] the nuclear translocation of the NF-κB p65 subunit and ii] phosphorylation of the c-jun subunit of AP-1 in the nucleus. Taken …
-
Production of stable bcs class ii drug suspensions by melt emulsification and subsequent incorporation into polymer strip films
… study, fine drug particles of two model drugs, fenofibrate and ibuprofen, are prepared by the melt emulsification technique. The influence of suspension formulation (i.e., the inclusion of polymers and surface-active agents) on particle stability is investigated. Moreover, different agitation …
-
Novel Metabolic Regulation of Invadopodia and Invasion by Acetyl-CoA Carboxylase and Lipogenesis
… status of ACC, as activation of AMPK by fenofibrate or AICAR resulted in increases in p-ACC and invadopodia loss. Cumulatively, these data provide the first evidence that de novo fatty acid synthesis and specific PC species are required for invadopodia and the invasive capacity of …
-
Exploring co-milling as a strategy to improve the dissolution of poorly water-soluble drugs
… distinct difference was observed between low Tg (fenofibrate) and high Tg (apremilast) drugs. Apremilast, milled below its Tg, exhibited progressive amorphization and supersaturation during dissolution testing. A strong linear correlation between melting point depression and maximum drug …
-
Advancing Toxicology-Based Cancer Risk Assessment with Informatics
… cancer risk. Two model nongenotoxic compounds (fenofibrate and methapyraline) were tested in short-term microarray studies to develop a framework for cancer risk assessment. It was determined that a threshold for potential key events could be derived using benchmark dose analysis in combination …
-
Transcriptional Regulation of T Helper Cell Differentiation in Autoimmunity
… genes and the PPARalpha agonists gemfibrozil and fenofibrate have been associated with protection from EAE. However, the manner in which these agents ameliorate disease is not well understood. We investigated the mechanism by which gemfibrozil induces immune deviation and protects mice from EAE. …
-
Development of Methods to Predict and Enhance the Physical Stability of Hot Melt Extruded Solid Dispersions
… Four model drugs felodipine, celecoxib, fenofibrate and carbamazepine and two polymeric matrices EUDRAGIT® EPO and Kollidon® VA 64 were formulated by hot melt extrusion and spin coating into solid dispersions. A series of physicochemical characterisation techniques including MTDSC, PXRD, …
-
Exploring the utility of the pig model for predicting bioavailability in humans
… bioenabling formulations of the model drugs fenofibrate and venetoclax. In addition, the ability of predicting food dependent bioavailability was assessed for both compounds. The formulations were evaluated in vivo in landrace (LR) pigs. Followed by a post-mortem assessment of the …
-
Hot-melt extrusion: A versatile pharmaceutical technology
… (HME) using Quality by Design (QbD) principles. Fenofibrate SLN were prepared by combining two processes: HME technology for melt-emulsification and high-pressure homogenization (HPH) for size reduction. Varying the process parameters enabled the production of SLN below 200 nm. At the end of a …
-
Novel continuous crystallization configurations for improved yield, purity and controlled crystal size distribution
… batch yield at equilibrium. In the third method, fenofibrate and fenofibric acid system with 1,3-di-otolylguanidine (DOTG) as complexing agent was studied. Complexing agent firstly formed hydrogen bonds with the impurity specifically, thus reduced the structure similarity of the API and impurity. …
-
Solubilisation of organic compounds of different polarity by interpolyelectrolyte complexes based on copolymer micelles
… capacity of formed PESC with solubilised fenofibrate. Complexes of positively charged oil in water microemulsion (ME) and copolymers of polyethylene glycol-block- polymethacrylic acid sodium salt (PEG-NaPMA) of varying chain length were investigated (PEMEC). The incorporation of a …
-
Studies to determine the mechanisms of the anti-atherosclerotic effects of eicosapentaenoic acid: possible role for endocannabinoids?
… and peripheral (heart and vascular) tissues. Fenofibrate, a lipid lowering control administered as a supplement to the atherogenic diet, was observed to significantly attenuate hypercholesterolaemia, endothelial dysfunction and elevated EC levels although no effect on cardiac remodelling was …
-
Impaired ketogenesis is implicated in intestinal stem cell function and epithelial regeneration in ulcerative colitis
… organoids via administration of PPARα agonist, fenofibrate. We performed scRNA-seq of βHB treated UC organoids finding that βHB specifically enhance the transcriptome of pathways that regulate mitochondrial function and reduces cellular stress, particularly in ISCs, by downregulating genes …