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Showing 1 to 2 of 2 for “"Fenobam"”.
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Allosteric Modulation of Metabotropic Glutamate Receptor 5 as a Treatment for Pain
… addition, I assessed the analgesic properties of fenobam, [N-(3-chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea], an anxiolytic recently identified as a selective and potent non-competitive negative allosteric modulator of mGlu5, and previously shown to be safe and effective in …
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Untersuchungen zur Expression und pharmakologischen Modulation des metabotropen Glutamatrezeptors 5 in Dystoniemodellen: dtsz Hamstermutante und DYT1 knock-in Maus
… mit dem negativen allosterischen Modulator Fenobam (20-50 mg/kg intraperitoneal, i.p.) und dem positiven allosterischen Modulator CDPPB (10-20 mg/kg i.p.) am mGluR5 im dtsz Hamstermodell, einem phänotypischen Modell der paroxysmalen Dystonie. Dabei wurden die akuten Effekte der Substanzen …