Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 174 for “"Female mice"”.
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Loss of basigin expression in the uterus reduces fertility in female mice
… and is important for fertility in both males and females. I hypothesized that loss of Bsg expression in the uterus reduces fertility in female mice by altering implantation, decidualization, lactate transporters and angiogenesis. In mice, global ablation of Bsg is embryonic lethal, which …
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Prenatal exposure to phthalates accelerates reproductive aging in multiple generations of female mice
… detrimental effects on reproduction in males and females. Specifically, in females, phthalates have been shown to accelerate primordial follicle recruitment, disrupt estrous cyclicity, inhibit ovarian steroidogenesis, and disrupt fertility. Furthermore, these effects have been observed in a …
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Genotype effects impact lipids and organ weights in female mice lacking carotenoid cleavage enzymes
… and their metabolites on lipid metabolism in female mice, CMO-I KO, CMO-II KO or wild type (WT) mice, 29-31 weeks old, were fed the following AIN-93G based diets for either 4 or 30 days: lycopene beadlet, 10% tomato powder, and their respective controls. We hypothesized that mice lacking …
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The effect of continuous infusion of human parathyroid hormone on bone architecture in female mice
… infusion of parathyroid hormone (PTH) in adult female mice, and to subsequently study the catabolic effects of PTH. Osmotic pumps were implanted subcutaneously and infused either vehicle, 40 pg/kg/day of PTH or 80 pg/kg/day of PTH for either 2 week or 4 week duration. Total body bone mineral …
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The Effect of Maternal Separation and Postnatal Oxytocin Administration on Social Recognition in Adolescent Female Mice
… dissertation was to determine whether separating female infant mouse pups from their mother, but not siblings, for 3 hrs daily, during the first two weeks of life, influences social recognition during adolescence (Experiment 1). This dissertation also sought to evaluate whether postnatal …
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Examination of voluntary wheel running on markers of adipose thermogenesis in intact and ovariectomized female mice
… wheel running (VWR) in ovariectomized (OVX) mice on whole body energy expenditure and body composition, key protein markers of thermogenesis and adipose tissue browning, and fluctuations in circulating and AT BDNF and receptor content. It was hypothesized VWR would either prevent or mitigate …
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The role of high affinity nicotinic acetylcholine receptors on anxiety-like behavior: a study in female mice
… of β2*nAChRs on anxiety-like behavior in female mice. In this study, antagonism and nicotine effects on anxiety-like behavior was investigated across the life span in 6, 12 and 24-month-old drug-naïve knockout (KO), heterozygous (HET) and a gain of function α6L9S mice and wild type (WT). …
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Nmp4 restricts bone marrow osteoprogenitors and parathyroid hormone induced bone formation in healthy and estrogen depleted female mice
… (PTH) in healthy and ovariectomized (OVX) female mice using a global knockout of the Nmp4 gene. Additionally, these mice have increased bone marrow osteoprogenitors and CD8+ T-cells which support osteoblast differentiation. The animals were not protected from bone loss following OVX, but …
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THE USE OF PREVENTATIVE CANNABIDIOL, CANNABIGEROL, AND MITRAGYNINE TO AMELIORATE MECHANICAL SENSITIVITY OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY IN FEMALE MICE
… but Mitragynine studies showed promise in female-only models. In the present set of experiments, we conduct dose-response studies using both single agents and combinations of these plant alkaloids. These studies were designed to fully evaluate the extent to which these compounds can …
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Thermoneutral Housing Did Not Impact the Combined Effects of External Loading and Raloxifene on Bone Morphology and Mechanical Properties in Growing Female Mice
… by non-invasive external tibial loading in female mice and combined with raloxifene treatment to assess their combined effect on bone morphology and mechanical properties. Thermoregulation is an important factor that could have physiological consequences on research outcomes, and was …
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Sex-influenced histopathological changes and the immunity during Toxoplasma gondii infection
Studies indicate female mice are more susceptible to T. gondii infection in comparison to male mice. The following studies were undertaken to enhance our understanding about the influence of sex in the immune response during T. gondii infection and the disease outcome in BALB/c mice. Early parasite …
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Characterizing Lung Inflammation in Agricultural Respiratory Exposures Between the Sexes
… including grain dust and pesticides. Although female workers make up approximately 25% of the agricultural working population, the majority of current research on the respiratory and inflammatory effects in agriculture has been conducted on male animal models and workers; very little has been …
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A Role for Microglia Activation in Modulating Behavior in a Variable Stress Model for Depression
… subregions of the hippocampus in both male and female mice following variable stress. Our findings demonstrate that following 6 days of variable stress female microglia acquire a more activated phenotype compared to microglia in males. These sex specific effects in microglia activation were also …
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Exploring the metabolic role of GPR30 in mice
… for the first time that GPR30 knockout (GPRKO) female mice were protected from high-fat diet (HFD)-induced obesity, glucose intolerance, and insulin resistance. The decreased body weight gain in GPRKO female mice is due to the reduction in body fat mass. These effects occurred in the absence of …
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Men and Women are Not Just From Different Planets: The Role of Sex-Based Differences in the Prevention of Non-Melanoma Skin Cancer
… chronic ultraviolet light B (UVB) exposure, male mice had greater tumor multiplicity, burden, and grade compared to female mice. Additionally, our acute UVB studies revealed decreased antioxidant capacity and cutaneous inflammation in male mice, suggesting that topical antioxidant or …
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ASSESSMENT OF NEUROTENSIN RECEPTOR AGONIST EFFECTS ON FEAR-POTENTIATED STARTLE
… by assessing this compound in both male and female C57BL/J6 mice using the fear-potentiated startle (FPS) paradigm. Startle chambers were equipped with a shock-grid floor, fluorescent light, and an acoustic startle speaker. Conditioning took place between the light and floor shock, and test …
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Sex and LRRK2 Genotype Differences in Inflammation and Dopaminergic Neurodegeneration in a Multi-Hit Model of Parkinson's Disease
… were addressed. To achieve this, male and female mice bearing the G2019S-LRRK2 mutation were exposed to a systemic lipopolysaccharide+paraquat (LPS+PQ) neurotoxicant challenge. Contrary to expectations, no additive/synergistic effects were observed between the G2019S mutation and LPS+PQ …
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Vitamin D Modulates Rett Syndrome Phenotypes and Underlying Cellular Pathways in an Mecp2-mutant Mouse Model
… is currently no effective treatment for RTT. Female RTT patients develop relatively normally during the first 6-18 months of life, after which they undergo a period of rapid regression, losing the ability to talk, walk and purposefully use their hands, in addition to suffering from …
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Sex-Based Differences in ACVR2B and GRB10 Expression in Skeletal Muscle During Induced Cancer Cachexia and Disuse
… cachexia and disuse-induced atrophy in male and female mice. Methods: Lewis Lung Carcinoma (LLC) was injected into the hind flank of male and female C57BL6/J mice at 8 weeks of age. Tumors were allowed to develop for 1, 2, 3, or 4 weeks and were compared to a PBS control. Disuse-induced male and …
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