Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Female Germline"”.
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Transcriptional regulation of the piRNA pathway in animal ovarian germ cells
… networks controlling the expression of the germline piRNA pathway components within the gonads of metazoan species remain largely unexplored. In contrast to the male germline piRNA pathway, which in mice is known to be activated by the testis-specific transcription factor A-MYB, the nature …
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Transcriptional and developmental consequences of aneuploidy during male meiosis
… the specialised cell division programme in the germline that generates haploid gametes. As these cells transmit genetic information to the next generation, the consequences of meiotic errors are not restricted to an organismal level, but can directly impact the fitness of the offspring. Mammals …
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Histone Demethylase LSD1 Restricts the Size of the Germline Stem Cell Niche in Drosophila Ovaries
… proper tissue homeostasis. I use the Drosophila female germline as an excellent model system to study niche development and function. Five to seven somatic cap cells form the ovarian stem cell niche and produce dpp, a BMP homolog necessary for the maintenance of germline stem cells (GSCs). …
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Evolution of nutrient sensing in the mTORC1 pathway
… Unmet fail to maintain the integrity of the female germline under methionine restriction. By tracing Unmet’s incorporation into the mTORC1 pathway, we show that Unmet was an independent methyltransferase before it was captured by flexible loops on the GATOR2 complex. These data suggest a …
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Genetic and biochemical analysis of the Drosophila melanogaster homolog of the human SCA2 gene
… function in the retina, sensory bristles, and female germline results in cellular and tissue morphological changes indicative of actin filament formation defects. Moreover, loss-of-function or overexpression of Datx2 in these same tissues results in alterations in the structural characteristics …
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Using Advanced In Vitro Models to Investigate the Adverse Effects of Methotrexate on the Developing Epigenome
… protocol as a proxy for the developing germline, also exhibited hypomethylation of imprinted DMRs and indicated an increased risk of reduced germline specification during development impacting offspring fertility and the health of future generations. Intriguingly, MTX treatment was shown …
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Isolation, characterisation and in vitro potential of Oogonial stem cells
… analysing their expression of pluripotency and germline markers, using RT-PCR, immunocytochemistry and Western blotting. The in vitro neo-oogenesis potential of the cells was explored by injecting fluorescently labelled cells into fragments of adult ovarian cortex and by forming aggregated …
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FOOD SECURITY: INNOVATIVE PLANT REPRODUCTIVE STRATEGY IN A CHANGING ENVIRONMENTAL CONDITION
Con il cambiamento climatico e l’aumento della popolazione, una delle nostre principali preoccupazioni è garantire la disponibilità alimentare globale. In questo contesto, è essenziale sviluppare strategie innovative per il miglioramento genetico delle piante. L'apomissia è un meccanismo …
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Using human genomics to decipher biological mechanisms underlying reproductive ageing and fertility in women
… our understanding of the genetic determinants of female reproductive ageing by employing state-of-art genomic and proteomic technologies with robust functional models. Chapter 3 uses whole exome sequence data to identify rare protein-coding variants associated with menopause timing in ~120K women …