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Showing 1 to 8 of 8 for “"Felodipine"”.
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Investigation of injection moulding for novel drug delivery systems. An investigation into the use of injection moulding to produce pharmaceutical dosage forms and to understand the relationship between materials, processing conditions and performance, in particular drug release and stability
… BCS class II drugs ibuprofen and the felodipine were selected based on their physicochemical properties. In the present work, a homogenous dispersion of drugs in the polymer matrices was achieved using Hot Melt Extrusion (HME) and extruded pellets obtained were used for the development …
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Temperature-dependent Terahertz Time-domain Spectroscopy as a Tool to Assess the Crystallisation Tendencies of Amorphous Drug-Polymer Systems
… ASDs. ASDs of three model drugs – indomethacin, felodipine, and clotrimazole – were prepared with the polymer HPMCAS across a range of drug loadings and polymer substitution grades. Differential scanning calorimetry (DSC) was used to determine glass transition temperatures, while THz-TDS provided …
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Mixed Polysaccharide Esters for Amorphous Solid Dispersion Oral Drug Delivery Vehicles
… polymers that prevented recrystallization of felodipine for hours and had excellent congruent polymer-drug release from the formulation at 20% drug loading. During the ring-opening reactions of the cellulose derivatives with glutaric anhydride we discovered that crosslinking and gelation can …
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Solubility Enhancement and Precipitation Inhibition of Poorly Water Soluble Compounds Utilizing Hot Melt Extrusion Technology
… utilized to prepare solid dispersions containing felodipine (FEL) or ketoconazole (KTZ) using hot-melt extrusion technology. The melting point depression approach was utilized to determine the miscibility and solubility of the model compounds within Soluplus® , of which felodipine demonstrated …
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Impact of Polymers on the Solution Crystal Growth Rate of a Poorly Water-Soluble Active Pharmaceutical Ingredient
… of a poorly soluble pharmaceutical compound, felodipine, was measured in the presence of various polymers. The growth rate studies were performed using a rotating disk apparatus so that the growth kinetics could be controlled and mathematically modeled. It was found that both polymer …
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Development of Methods to Predict and Enhance the Physical Stability of Hot Melt Extruded Solid Dispersions
… prepared by hot melt extrusion. Four model drugs felodipine, celecoxib, fenofibrate and carbamazepine and two polymeric matrices EUDRAGIT® EPO and Kollidon® VA 64 were formulated by hot melt extrusion and spin coating into solid dispersions. A series of physicochemical characterisation techniques …
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Impact of modified carbon dioxide mobile phases on detection on packed-column supercritical fluid chromatography
… from propellants, phenylurea herbicides, and felodipine extracted from a sustained release tablet by SFE are presented. A high performance liquid chromatography-evaporative light scattering detector (HPLC-ELSD) has been modified and interfaced with SFC. The detector performance was evaluated …