Global ETD Search
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Showing 1 to 4 of 4 for “"Febuxostat"”.
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Effects of Febuxostat on Autistic Behaviors and Computational Investigations of Diffusion and Pharmacokinetics
… brain tissue induced by xanthine oxidase (XO). Febuxostat is a new FDA approved XO-inhibitor that has been shown to be more selective and potent than allopurinol in patients with gout. The first study developed a computational model to calculate an effective diffusion constant (Deff) of …
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Biomarker analysis for APRT deficiency diagnosis using UPLC-MS/MS
… can be treated with the drugs allopurinol and febuxostat, which prevent the conversion of adenine to DHA and thus reduce formation of kidney stones in APRT deficiency patients. UPLC-MS/MS method for simultaneous quantification of DHA, adenine and the drugs, allopurinol, oxypurinol and …
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Renal and Blood Pressure Effects of Xanthine Oxidase Inhibitors in the FAST trial
… with xanthine oxidase inhibitors. Data from the Febuxostat versus Allopurinol Streamlined (FAST) trial is presented in three studies:1) Up-Titration of Allopurinol in Patients with Gout. Patients recruited into the FAST trial have their sUA levels measured at the screening visit and patients with …
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PRG4/CD44/PP2A Signaling Axis: A Significant Regulator of Gout Arthritis
… crystals. Fingolimod (PP2A activating drug) and febuxostat (XO inhibitor) were assessed for their ability to regulate PP2A and XO activity, UA production, ROS generation and IL-1b secretion. Anti-inflammatory effect of fingolimod was assessed in vivo. Phagocytic activation of gout and normal …