Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Fear memory"”.
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Molecular and epigenetic mechanisms of fear memory
Numerous memory studies have demonstrated that epigenetic-mediated transcriptional regulation, such as post-translational histone modifications, is essential to memory formation and maintenance. Moreover, many studies on the mechanisms of memory have focused on fear memories underlying traumatic …
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Inhibitory Control of Contextual Fear Memory and Memory Specificity
… neurons and GABA receptors in learning and memory. The study consists of three major components. In the first component (Chapter 2), I developed a novel technique to selectively target and control GABAergic interneurons (NDNF cells) distributed at the SLM of the hippocampus. With this …
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Protein SUMOylation is a Sex-Specific Regulator of Fear Memory Formation in the Amygdala
… of protein ubiquitination in the formation of fear-based memories, few studies have been conducted examining the role that SUMOylation plays in this same process. The amygdala is the main site of storage for emotional memories and there is strong evidence that protein ubiquitination is critical …
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The role of estrogen receptor manipulation on persistent fear memory induced by traumatic stress exposure
… psychiatric disorder which stems from fear memory persistence after exposure to a traumatic experience. PTSD is associated with a high socioeconomic cost, as well as a higher prevalence rate in women than in men, though the reason behind this sex difference remains unknown. A possible …
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Effects of LTD-blocking Tat-GluR2 Peptide on Contextual Fear Memory Impairments Induced by Cannabinoids
… mechanisms underlying cannabinoid impairment of fear memory is not clear. This study investigated the effects of the synthetic cannabinoid HU210 and the endocannabinoid hydrolysis inhibitor JZL 195 on fear memory following contextual fear conditioning (CFC; an animal model of fear). The long-term …
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The precision of initial context fear memory encoding determines the behavioural, cognitive and molecular changes that occur following recall
Maintaining memory relevance in the face of an ever-changing world is essential for survival. When animals form memories about specific environmental contexts and their associations, they must be able to continually assess the validity of both those associations and of the contextual memories …
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Sex-differences in proteasome-independent roles of the ubiquitin proteasome system in memory formation
Fear memory formation requires a coordination of molecular events, including protein synthesis, protein degradation, and epigenetic regulation of gene expression, throughout a circuit of brain regions. One mechanism highly studied for its involvement in protein degradation during fear memory is the …
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Non-proteolytic roles of the ubiquitin-proteasome system in memory formation across the lifespan
Memory formation and decline are driven by complex molecular mechanisms and region-specific changes in the brain. Epigenetic modifications, such as histone monoubiquitination and ubiquitin signaling, have emerged as key players in these processes. While monoubiquitination of histone H2B is a …
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Revised - THE ROLE OF GAD67/65 IN THE THERAPEUTIC EFFECTS OF KETAMINE AND FLUOXETINE IN FEAR-CONDITIONED MICE
… (FLX) and acute ketamine treatment decreased fear response in a contextual fear paradigm in male C57/BL mice. In rodents, fear conditioning (FC) is commonly used in the literature to induce behaviors related to PTSD. The mammalian central fear memory circuit involves a dynamic interplay …
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NMDAR-PSD95-nNOS Axis-Mediated Molecular Mechanisms in the Basolateral Amygdala Underlying Fear Consolidation
Fear is an evolutionarily conserved response that can facilitate avoidance learning and promote survival, but excessive and persistent fear responses lead to development of phobias, generalized fear, and post-traumatic stress disorder. The primary goal of experiments in this dissertation is to …
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Calcium-Stimulated Adenylyl Cyclases are Critical Modulators of Fear Learning and Experience-Dependent Plasticity
… of what modulates stress-facilitated memory processing will help identify new targets for possible therapeutic intervention. Recent evidence suggests a role of the Ca<super>2+</super>-stimulated adenylyl cyclases: AC), AC1 and AC8, in modulating fear memory. …
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Dopaminergic modulation of basolateral amygdala for fear extinction
The extinction of conditioned fear responses is crucial for adaptive behavior, and its impairment is a hallmark of anxiety disorders such as post-traumatic stress disorder. During fear extinction learning, a new memory is formed in basolateral amygdala (BLA) reward neurons, which inhibits the BLA …
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Olfactory Processing in the Piriform Cortex of Awake, Freely Moving Mice
… discrimination but did impair acquisition of a fear memory. This supports prior work from other labs indicating a role for PC in olfactory learning, expanding its role in olfactory processing. In total, this work highlights the need for more studies to clarify the coding strategies implemented …
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The GluK4 Kainate Receptor Subunit Regulates Mood, Memory and Excitotoxic Neurodegeneration
… GluK4 knockout mice also demonstrated impaired fear memory and spatial memory. Furthermore, my findings indicate that GluK4 is a key mediator of excitotoxic neurodegeneration: GluK4 knockout mice showed robust neuroprotection in the Cornu Ammonis 3 (CA3) region of the hippocampus following …
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The Effect of Rapamycin Paired with Traumatic Memory Activation on Cognitive Performance in Veterans Diagnosed with PTSD
… can prevent the reconsolidation of a reactivated fear memory, thereby reducing its emotional strength at a neurochemical level. The aim of the current study was to determine if pairing rapamycin with traumatic memory reactivation in male veterans with combat-related PTSD would lead to an …
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Neurodegeneration and behavior in rodents treated with chronic methamphetamine
… does not result in novel object recognition or fear memory deficits in male mice but does cause reduced locomotion in both male and female mice (Chapter 3). Finally, I discuss my findings (Chapter 4) within the context of prior meth neurotoxicity literature, expand on the sex differences noted …
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Fear Not: Exploring the Role of Memory Suppression During Pavlovian Fear Extinction
… assessments of the retrieval stopping model of fear extinction—a model reframing century-old theories of how we overcome fears. The model marries two hitherto disconnected research areas: memory suppression and Pavlovian fear extinction. Memory suppression is a cognitive process whereby …
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The Medial Entorhinal Cortex's role in temporal and working memory : characterization of a mouse lacking synaptic transmission in Medial Entorhinal Cortex Layer III
Declarative memory requires the integration and association of multiple input streams within the medial temporal lobe. Understanding the role each neuronal circuit and projection plays in learning and memory is essential to understanding how declarative and episodic-like memories are formed. This …
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Cadmium exposure impairs adult neurogenesis, cognition, and olfactory memory in mice
… of hippocampus-dependent learning and memory in the novel object location test, the T-maze test, and the contextual fear memory test, but not in the water maze test in young adult mice. In addition, I also found that Cd exposure impairs olfactory memory in mice. Adult neurogenesis is a …
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Neurophysiological and behavioural characterisation of a 16p11.2 microdeletion rat model of autism spectrum disorder
… paradigms, including those testing learning and memory, sociability, and cognitive flexibility. In exploring possible mechanisms underlying these deficits, aberrant interneuron development has been implicated in 16p11.2 deletion pathology; somatostatin (SST)-expressing interneurons of the …
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