Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Fear extinction"”.
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Dopaminergic modulation of basolateral amygdala for fear extinction
The extinction of conditioned fear responses is crucial for adaptive behavior, and its impairment is a hallmark of anxiety disorders such as post-traumatic stress disorder. During fear extinction learning, a new memory is formed in basolateral amygdala (BLA) reward neurons, which inhibits the BLA …
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FEAR EXTINCTION AND INFRALIMBIC CORTEX IMPAIRMENT AFTER MILD TRAUMATIC BRAIN INJURY
… A hallmark of these conditions is impaired fear extinction, the process by which learned fear responses are inhibited in safe contexts. This dysfunction contributes to maladaptive fear expression and is linked to altered neurocircuitry, particularly in the infralimbic cortex (IL), a key …
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The Role of the Infralimbic-Basal Forebrain Pathway in Fear Extinction
… emotion regulation, and its failure to regulate extinction of aversive memories is associated with Post Traumatic Stress Disorder. Study of how the Infralimbic cortex (IL), a subregion of the mPFC, directly communicates with the Basolateral Amygdala (IL-BLA), has thus far failed to uncover the …
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Fear Not: Exploring the Role of Memory Suppression During Pavlovian Fear Extinction
… assessments of the retrieval stopping model of fear extinction—a model reframing century-old theories of how we overcome fears. The model marries two hitherto disconnected research areas: memory suppression and Pavlovian fear extinction. Memory suppression is a cognitive process whereby …
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Suppressing What Hurts: The Role of Prefrontal-Thalamic Pathways in Inhibitory Control of Intrusive Thoughts and Conditioned Fear
… in mediating such top-down control. Further, fear extinction which forms the basis of exposure therapy has been hypothesized to employ retrieval stopping processes. If this holds true, humans may be capable of extinguishing fear by suppressing its retrieval. In rodents, the NRe has been widely …
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Group II Metabolic Glutamate Receptors in the Basal Amygdala Regulate Sleep and Fear-Induced Alterations in Sleep
… with the CNA, is involved in conditioned fear and fear extinction. However, the potential role of the BA in the regulation of sleep has received little attention. In this study, we investigated the role of mGlu II receptors in sleep and stress-induced alterations in sleep.</p> <p>In work …
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Evaluation of the Role of Astrocyte Glutamate Transport and of Synaptic NMDA Receptor Subtype Representation in the Pathogenesis of PTSD
… during situational trauma selectively inhibits fear extinction memory processes in the prefrontal cortex, but not of conditioned fear memory processes in the amygdala, due to differences between these brain regions in expression of NMDA receptor subtypes. The effect of GLT-1 manipulation was …
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The long-term effects of reproductive experience on the neurobiology of anxiety and its treatment: a cross species approach in female rats and women
… cycle impacted anxiety-like behaviour and fear extinction (learned fear inhibition) in nulliparous (virgin) rats, but not primiparous (reproductively experienced) rats. Primiparous rats also had altered anxiety-related gene expression (GABAA receptor subunits and corticotrophin-releasing …
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The effects of chronic intermittent ethanol exposure on fear conditioning in rats: an investigation of the comorbidity of PTSD and AUD
… ethanol (CIE), a model of alcohol dependence, on fear conditioning, a model of fear learning that engages circuits that are dysregulated in PTSD, in male Long Evans rats. We further expanded this research by looking at the effects of this exposure on subsequent ethanol drinking behaviors, using a …
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Infusion of oxytocin into the basolateral amygdala facilitates, whereas infusion into the central nucleus impairs extinction of context conditioned fear responses in rats
… may account for these differences in fear responses. Specifically, i.c.v. OT may target other amygdala areas such as the basolateral amygdala (BLA), thereby increasing freezing responses. This thesis investigated CeA and BLA infusions of OT on the acquisition and extinction of context …
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Antidepressant-Like Effects of Ketamine on Fear Conditioning and Extinction
… emotional events can be studied in animals using fear conditioning and extinction paradigms. Fear conditioning trains an animal to associate a neutral cue with an emotionally aversive experience, while extinction learning challenges this association by forming a new memory that identifies the cue …
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Serotonin Modulates the Maturation of the Medial Prefrontal Cortex and Hippocampus: Relevance to the Etiology of Emotional and Cognitive Behaviors
… the ability of PN-FLX mice to extinguish learned fear ("fear extinction"), as performance in this behavioral paradigm is modulated by IL/PL output. Congruent with their altered IL/PL balance, PN-FLX mice display deficits in fear extinction learning and recall. Mimicking the diminished IL/PL ratio …
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An attempt to develop a laboratory model of superstitious learning of threat
… & Gelder, 1996), prevent non-occurrence of the feared outcome from disconfirming the threat belief and eventual fear extinction. Quite the opposite, instrumental attempts to prevent imminent catastrophe lead non-occurrence of the feared outcome to be perceived as confirmation that the threat is …
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Forebrain Noradrenergic Alterations and Anxiety After Myocardial Infarction
… suppression of emotional responses to learned fear cues when the cues no longer predict an aversive event. Therefore we determined if fear extinction and recall of extinction were impaired in MI rats. We found that MI rats exhibited greater emotional responses (freezing) to tones previously …
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Multisite optical neuromodulation : invention and application to emotion circuits
… involved in learning, expressing, and regulating fear, may spread across many brain regions and show functional heterogeneity among spatially overlapping cell types within each region. These populations, represented as discrete circuit elements in models of circuit function, may also show …
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Characterization of a novel recombinant inbred mouse model of high fear
Fear and anxiety are evolutionarily conserved emotions. They act as a signal of danger and threat to trigger the appropriate adaptive responses ensuring species survival. However, aberrant expression of these emotions, and an inability to cope can lead to anxiety disorders such as post-traumatic …
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EFFECTS OF ACUTE THC ADMINISTRATION ON EXTINCTION OF CONDITIONED FEAR RESPONSES IN HUMANS: A FUNCTIONAL ANALYSIS OF HIGH DENSITY EEG
… 9-tetrahyrdrocannabidol (THC) administration on extinction of conditioned fear responses. Fear conditioning was initiated using a differential classical conditioning paradigm that paired an aversive unconditioned stimulus (shock) with a signaling stimulus (CS+), whereas another stimulus served as …
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The role of puberty in the development of the adolescent rodent medial prefrontal cortex and behavior
… that are influenced by estrogens, such as fear extinction or cognitive behaviors. Finally, we provide evidence in Chapter 4 that the developmental events occurring at pubertal onset may render adolescents susceptible to the effects of stress, as previous human and animal literature suggests …
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