Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Fear Learning"”.
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The Mechanisms Underlying Olfactory Vicarious Fear Learning in Rats
Vicarious learning occurs when an “observer” animal, naïve to a conditioned stimulus, is in the presence of a “demonstrator” animal that has been conditioned to react to the stimulus. This project aimed to elucidate the mechanisms behind olfactory vicarious learning to an aversive cue; namely, how …
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Fear Learning and the Olfactory Bulb: Neural Correlates of Behavioral Fear Generalization
<p>The exploration of how learning alters neural coding to guide behaviors remains fundamental to neuroscience. At the most basic level, the ability for organisms to flexibly adapt to changing environments and situations is paramount to biological success and often manifests in behavioral responses …
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Calcium-Stimulated Adenylyl Cyclases are Critical Modulators of Fear Learning and Experience-Dependent Plasticity
… cyclases: AC), AC1 and AC8, in modulating fear memory. Ca<super>2+</super>-stimulated AC activity couples neuronal activity and intracellular Ca<super>2+</super> increases to the production of cAMP, and therefore, can very tightly regulate signal transduction after learning; yet, the …
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Pre-Stimulus Anticipation and Unconscious Fear Learning Disparities in Individuals with Varying Levels of Anxiety
… unconscious threat anticipation on subsequent fear responses in associative learning. Additionally, we explored the differences in pre-stimulus anticipation among individuals with varying levels of anxiety. Electrodermal response (EDA) was chosen as a primary measure due to its robustness in …
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Fear Conditioning as an Intermediate Phenotype: An RDoC Inspired Methodological Analysis
… novel experimental and statistical approaches. Fear learning paradigms represent a promising methodology for elucidating connections between acute threat (“fear”) circuitry and fear-related clinical difficulties. However, traditional analytical approaches rely on central tendency statistics, …
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Decoding observational learning : a circuit level analysis of the social brain
… conserved social behaviors. Observational fear learning is one such social behavior that offers a distinct advantage for survival and is thus highly conserved across various species including rodents (Heyes et al. 1990; Kavaliers et al. 2001), monkeys (Mineka et al. 1984), and humans …
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Neurobiologically-motivated treatments for post-traumatic stress disorder in an animal model
… stress administered to rats enhances fear learning and increases plasma acylated ghrelin. This effect is independent of the hypothalamus-pituitary-adrenal (HPA) axis since it was unaffected by prior bilateral adrenalectomy. Chronic exposure to a ghrelin receptor agonist, without …
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The social transmission of associative fear in rats : mechanisms and applications of fear conditioning by proxy
… (e.g., freezing). This direct associative learning is only one technique under which individuals can learn about potential threats, but its convenient design and the robust production of responses makes direct fear conditioning the most frequently used paradigm in the research of fear and …
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Structure-Function and Behavioral Studies on the Glutamate Delta-1 Receptor
… treatment. Amygdala functions in associative fear learning while prefrontal cortex plays a role in working memory. We found molecular abnormalities in amygdala and prefrontal cortex. Thus we tested the effect of GluD1 deletion on amygdalar and prefrontal cortex associated learning tasks. We …
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Molecular and epigenetic mechanisms of fear memory
… on the mechanisms of memory have focused on fear memories underlying traumatic events, which helps to understand post-traumatic stress disorder (PTSD). However, these mainly focus on individuals directly experiencing the event, while different species have shown the ability to learn fear …
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PREFRONTAL CORTEX ACTIVITY DURING ATTENTIONAL BIAS CONDITIONING WITH FEARFUL FACES: A NEAR-INFRARED SPECTROSCOPY ANALYSIS
<p>Observing a fearful facial expression elicits an automatic orienting of attention. Past research focusing on fear conditioning has used an unconditioned stimulus that the participant directly experiences (e.g. shock). Other research has focused on observational fear learning where the …
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Computational models of neuronal fear and addiction circuits
… neuroscience spectrum. Subcircuits related to fear and addiction are considered at three levels, network, cellular and intracellular levels. In the area of fear learning, we developed biophysically realistic network models for two regions of the fear circuit. We first developed a computational …
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ACUTE NICOTINE-DEPENDENT ALTERATIONS IN ASSOCIATIVE LEARNING INTERFERE WITH BACKWARDS TRACE CONDITIONED SAFETY
… processing, as safety cues can decrease fear in the presence of previously learned danger cues. Further, there are clinical implications in understanding learned safety, as individuals with PTSD present with deficits in learned safety. Additionally, there is a well established …
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Neurobehavioral Mechanisms Supporting the Generalization of Learned Fear in Humans
… do not) pose a threat. Results show that human fear generalization is a complex phenomenon affected by the perceptual and conceptual nature of the stimulus. Brain regions and functional networks involved in fear generalization comprise cortical areas involved in coding the representation of …
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The effects of chronic intermittent ethanol exposure on fear conditioning in rats: an investigation of the comorbidity of PTSD and AUD
… ethanol (CIE), a model of alcohol dependence, on fear conditioning, a model of fear learning that engages circuits that are dysregulated in PTSD, in male Long Evans rats. We further expanded this research by looking at the effects of this exposure on subsequent ethanol drinking behaviors, using a …
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Primate Ventromedial Prefrontal Cortex and the Physiological and Behavioural Dysfunction Characteristic of Mood and Anxiety Disorders
… behaviour; and (iii) negative affect including fear learning, stress recovery and the intolerance of uncertainty. To provide further insight into the mechanism of action of antidepressants, the efficacy of selected treatments is tested on changes induced by over-activity of these regions. Beyond …
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Cellular and synaptic pathophysiology in a rat model of Fragile X syndrome
… connectivity which is associated with fear learning and anxiety behaviours (Burgos- Robles et al., 2009). Using retrograde tracing, we showed layer 5 pyramidal neurons that provide long-range connections to the basal amygdala were intrinsically hypoexcitable in Fmr1 KO rats. This …
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The Role of Rac1 in Synaptic Plasticity, Learning and Memory
During the process of learning and memory, neuronal synapses undergo changes involving gene expression, protein synthesis, and cytoarchitectural remodeling, referred to as synaptic plasticity. Changes in the morphology of synapses are necessary for learning and memory storage, and require the …