Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"FcRn"”.
-
THE FUNCTIONAL REGULATION OF FCRN EXPRESSION AND FCRN-MEDIATED ANTIGEN PRESENTATION
The neonatal Fc receptor for IgG (FcRn), a major histocompatibility complex (MHC) class I-related molecule, plays an important role in IgG transport and protection. The transport of IgG across epithelial and endothelial barriers and the IgG homeostasis maintained by FcRn contributes to the …
-
Targeting the Neonatal Fc Receptor, FcRn, to Treat Autoimmunity and Elucidation of Sites of FcRn Function
The neonatal Fc receptor, FcRn, is expressed in many different cell types and serves several functions, some of which are cell type-specific. A function common to most cell types that express this receptor is salvage of IgG from cellular degradation which is responsible for the long in vivo …
-
Using Advanced Fluorescence Microscopy to Analyze Intracellular Trafficking of FcRn In Live Cells
The file named "GanZhou.pdf" is the primary dissertation file. All other files ("*.mov") are supplemental files and may be viewed individually.
-
Transepithelial transport of nanoparticles targeted to the neonatal Fc receptor for oral delivery applications
… oral delivery of NPs. The neonatal Fc receptor (FcRn) mediates IgG antibody transport across epithelial barriers. It was discovered as the receptor in the neonatal intestine that transports IgG in breast milk from mother to offspring. However, FcRn is expressed into adulthood at levels similar to …
-
Challenges in the Pharmacokinetics of Therapeutic Proteins
… and 2) the ontogeny of the neonatal Fc receptor (FcRn) expression along with its effect on the pharmacokinetics of monoclonal antibodies (mAbs) during development.</p> <p>TMDD often well describes the pharmacokinetics of therapeutic proteins that have high specificity and affinity of binding to …
-
Rational engineering strategies to improve antibody fragment pharmacokinetics and bioavailability
… an inability to bind the neonatal Fc receptor (FcRn) – the receptor responsible for the long half-lives of natural IgG and serum albumin. A common approach to circumvent these limitations is to enable engagement with the half-life extending neonatal Fc receptor (FcRn). This is usually achieved …
-
Characterization of Fc receptor family proteins in vaginal and endocervical epithelia
… a particular focus on the neonatal Fc receptor (FcRn). Fc receptors are a large family of proteins that bind to the Fc region of immunoglobulins (Igs) and function in Ig transport and effector functions. These receptors could function in enhancing the delivery of bNAbs in microbicide formulations …
-
Engineering the antibody-TRIM21 interface for the improved intracellular clearance of pathogenic targets
… Despite residing within the binding site of FcRn, T256P does not affect FcRn binding or in vivo half-life. Functionally, enhanced TRIM21 affinity improves intracellular neutralisation of diverse pathogenic targets. In cellular models, hIgG1-T256P increases clearance of adenovirus infection …
-
Modeling approaches to characterize the disposition of monoclonal antibodies
… elimination involving the neonatal Fc receptor (FcRn) and endogenous IgG (IgGendo). The remarkable discrepancy between the simplicity of biodistribution data and the complexity of published PBPK models translates in parameter identifiability issues. In this thesis, we address this problem with a …
-
Studies of immunoglobulin receptors and human proximal tubular cells
… receptor (pIgR), the neonatal receptor (FcRn), the Fcα/μR, the classical IgG receptors (FcγR1, γIIa, γIIb, γIII and the related FcR γ-chain) and the classical IgA receptor (FcαR). None of the classical IgG receptors were expressed by PTEC, nor was the classical IgA receptor. However, the …
-
Engineering novel antibody-based molecules to probe the role of the immunoglobulin hinge and generate a potential cancer vaccine
… taken up by dendritic cells via their FcRn receptors, with the aim of stimulating a strong anti-tumour immune response. Human MAGE-A2 fused to either human IgG1 Fc or mouse IgG2a Fc had been successfully produced and purified using Protein-G Sepharose. Results from Coomassie staining …
-
Introspective knowledge acquisition for case retrieval networks in textual case base reasoning.
… called the Fast Case Retrieval Network (FCRN) which eliminates redundant run-time computations to improve retrieval speed. Experimental results show FCRN's ability to scale up over high dimensional textual casebases. Finally, we investigate novel ways of visualizing and estimating …
-
Determinants of antibody specificity
… effects independent of neonatal Fc receptor (FcRn) binding. Focused on the antibody variable region, we next utilized our nonspecificity assay as a sorting tool to look at a naive repertoire library. We found significant nonspecificity in the VH6 class of antibodies, driven by a poorly behaved …
-
Development of nanoparticles for oral delivery of insulin
… epithelial lining, NPs were designed to use the FcRn transport pathway that mediates IgG antibody transport across epithelial barriers. We report the successful chemical conjugation of the Fc fragment on the surface of Ins-Eud- NPs by overcoming the presence of non-ideal conjugation parameters …